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Fgf12 fibroblast growth factor 12 [ Mus musculus (house mouse) ]

Gene ID: 14167, updated on 21-Apr-2024

Summary

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Official Symbol
Fgf12provided by MGI
Official Full Name
fibroblast growth factor 12provided by MGI
Primary source
MGI:MGI:109183
See related
Ensembl:ENSMUSG00000022523 AllianceGenome:MGI:109183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf1; FHF-1; Fgf1a; FGF-12; B230343J05Rik
Summary
Predicted to enable heparin binding activity; sodium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of sodium ion transport. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.5), cortex adult (RPKM 7.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B2; 16 19.38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (27976535..28571995, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (28157783..28753243, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40500 Neighboring gene zinc finger protein 106 pseudogene Neighboring gene predicted gene 10823 Neighboring gene STARR-seq mESC enhancer starr_40501 Neighboring gene STARR-seq mESC enhancer starr_40502 Neighboring gene STARR-seq mESC enhancer starr_40503 Neighboring gene STARR-seq mESC enhancer starr_40504 Neighboring gene STARR-seq mESC enhancer starr_40505 Neighboring gene STARR-seq mESC enhancer starr_40506 Neighboring gene predicted gene, 52250 Neighboring gene predicted gene, 53944 Neighboring gene STARR-seq mESC enhancer starr_40507 Neighboring gene STARR-seq mESC enhancer starr_40509 Neighboring gene predicted gene, 46548 Neighboring gene microRNA 690 Neighboring gene STARR-seq mESC enhancer starr_40512 Neighboring gene STARR-seq mESC enhancer starr_40513 Neighboring gene STARR-seq mESC enhancer starr_40515 Neighboring gene STARR-seq mESC enhancer starr_40516 Neighboring gene predicted gene, 20018 Neighboring gene Mab-21 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). Woo J, et al. Int J Mol Sci, 2022 Aug 22. PMID 36012732, Free PMC Article
  2. Macrophage-specific FGF12 promotes liver fibrosis progression in mice. Li S, et al. Hepatology, 2023 Mar 1. PMID 35753047
  3. Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Liu A, et al. Peptides, 2022 Jul. PMID 35304156
  4. FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension. Yeo Y, et al. Hypertension, 2020 Dec. PMID 33100045
  5. Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Hanada Y, et al. Sci Rep, 2018 Jul 31. PMID 30065296, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage-specific FGF12 promotes liver fibrosis progression in mice.
    Title: Macrophage-specific FGF12 promotes liver fibrosis progression in mice.
  2. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).
    Title: Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).
  3. Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress.
    Title: Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress.
  4. FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension.
    Title: FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension.
  5. FGF12 is necessary for normal auditory and equilibrium function.
    Title: Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.
  6. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
    Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
  7. FGF21 does not appear necessary for exercise-induced systemic and hepatic mitochondrial adaptations, but the increased adiposity, hyperinsulinemia, and impairments in hepatic mitochondrial function induced by FGF21 deficiency can be partially rescued by daily wheel running exercise.
    Title: Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations.
  8. results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA+/CGRP+ nociceptors.
    Title: Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia.
  9. x-ray crystal structure of FHF1b
    Title: Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fibroblast growth factor 12
Names
fibroblast growth factor 1a
fibroblast growth factor homologous factor 1
myocyte-activating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276419.2 → NP_001263348.1  fibroblast growth factor 12 isoform c

    See identical proteins and their annotated locations for NP_001263348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC154619, AC154656, AC154663, AK011712, AK034150, AK034335, AK046130, BY477982
    UniProtKB/TrEMBL
    A0A338P764
    Conserved Domains (1) summary
    pfam00167
    Location:38 → 162
    FGF; Fibroblast growth factor

  2. NM_001276420.1 → NP_001263349.1  fibroblast growth factor 12 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' exon structure and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform d which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC154663, AK018774, AK148215, BP768136
    Consensus CDS
    CCDS88908.1
    UniProtKB/TrEMBL
    A0A338P752, Q3UFZ2
    Related
    ENSMUSP00000156274.2, ENSMUST00000231717.2
    Conserved Domains (1) summary
    cl00060
    Location:76 → 105
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  3. NM_001357064.1 → NP_001343993.1  fibroblast growth factor 12 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC154619, AC154656, AC154663
    Conserved Domains (1) summary
    pfam00167
    Location:1 → 112
    FGF; Fibroblast growth factor

  4. NM_010199.4 → NP_034329.1  fibroblast growth factor 12 isoform b

    See identical proteins and their annotated locations for NP_034329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC154619, AK034150, AK034335, AK046130, BB611389, BY477982, CX239635
    Consensus CDS
    CCDS88909.1
    UniProtKB/Swiss-Prot
    P61329
    Related
    ENSMUSP00000155924.2, ENSMUST00000232352.2
    Conserved Domains (1) summary
    pfam00167
    Location:12 → 136
    FGF; Fibroblast growth factor

  5. NM_183064.5 → NP_898887.1  fibroblast growth factor 12 isoform a

    See identical proteins and their annotated locations for NP_898887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC154619, AC154663, AK034150, AK034335, AK046130, AK148215, BY477982
    Consensus CDS
    CCDS28092.1
    UniProtKB/Swiss-Prot
    P61329, Q924B4
    UniProtKB/TrEMBL
    A0A7U3JW65
    Related
    ENSMUSP00000097601.2, ENSMUST00000100024.3
    Conserved Domains (1) summary
    pfam00167
    Location:74 → 198
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    27976535..28571995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61329.1 GenPept UniProtKB/Swiss-Prot:P61329

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