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Fes feline sarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 14159, updated on 21-Apr-2024

Summary

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Official Symbol
Fesprovided by MGI
Official Full Name
feline sarcoma oncogeneprovided by MGI
Primary source
MGI:MGI:95514
See related
Ensembl:ENSMUSG00000053158 AllianceGenome:MGI:95514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FPS; c-fes
Summary
Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.4), lung adult (RPKM 18.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80027506..80037702, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80377758..80387954, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and beta1 integrin receptors. Smith JA, et al. Cell Signal, 2010 Mar. PMID 19892014
  2. fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation. Truesdell PF, et al. Exp Cell Res, 2009 Oct 15. PMID 19732771
  3. The Fps/Fes kinase regulates leucocyte recruitment and extravasation during inflammation. Parsons SA, et al. Immunology, 2007 Dec. PMID 17627769, Free PMC Article
  4. The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-kappaB activation, and TNF-alpha secretion in macrophages. Parsons SA, et al. J Leukoc Biol, 2006 Dec. PMID 16959897
  5. Hemostatic and hematological abnormalities in gain-of-function fps/fes transgenic mice are associated with the angiogenic phenotype. Sangrar W, et al. J Thromb Haemost, 2004 Nov. PMID 15550033

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes.
    Title: Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes.
  2. The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
    Title: The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
  3. FES is a driver of melanoma progression in a mouse model.
    Title: Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
  4. Fes inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages.
    Title: Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis, and infiltrating macrophages.
  5. Fes protein is activated downstream of activated Kit receptor, and this is facilitated by the Fes SH2 domain binding to Kit, and by trans-phosphorylation by Fyn kinase.
    Title: Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and beta1 integrin receptors.
  6. Fps/Fes is not essential for the maintenance of mammary epithelial cell adherens junctions in lactating mammae.
    Title: fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation.
  7. Fes was expressed in mouse brain. Experiments with transfected mouse cDNA show that Fes links Sema3A signals to CRMP-CRAM.
    Title: Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.
  8. Fps/Fes and Fer are expressed in human and mouse platelets, and are activated following stimulation with collagen and collagen-related peptide (CRP), suggesting a role in GPVI receptor signaling
    Title: Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation.
  9. The increased numbers and survival of erythroid progenitors from fps(MF) mice, and their differential responsiveness to SCF and EPO, implicates Fps/Fes in the commitment of multilineage progenitors to the erythroid lineage.
    Title: Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival.
  10. Hematopoiesis is deregulated in the absence of Fps and Fer kinases. Qualitative differences in myeloid colonies from compound mutant mice suggested a role for Fps and Fer kinases in regulating cell-cell adhesion or a skewing in cellularity of colonies.
    Title: Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to vitamin D ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fes/Fps
Names
proto-oncogene c-Fes
proto-oncogene tyrosine-protein kinase Fes/Fps
tyrosine kinase Fps/Fes
NP_034324.2
XP_006540667.1
XP_036008562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010194.2 → NP_034324.2  tyrosine-protein kinase Fes/Fps

    See identical proteins and their annotated locations for NP_034324.2

    Status: VALIDATED

    Source sequence(s)
    AC136740, AK143639, BC038130
    Consensus CDS
    CCDS39999.1
    UniProtKB/Swiss-Prot
    P16879, Q3TD20, Q62122, Q8CG02
    UniProtKB/TrEMBL
    A0A0U1RPM2
    Related
    ENSMUSP00000079733.7, ENSMUST00000080932.8
    Conserved Domains (3) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:564 → 814
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80027506..80037702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540604.5 → XP_006540667.1  tyrosine-protein kinase Fes/Fps isoform X1

    See identical proteins and their annotated locations for XP_006540667.1

    UniProtKB/Swiss-Prot
    P16879, Q3TD20, Q62122, Q8CG02
    UniProtKB/TrEMBL
    A0A0U1RPM2
    Related
    ENSMUSP00000146041.2, ENSMUST00000206728.2
    Conserved Domains (3) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:564 → 814
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036152669.1 → XP_036008562.1  tyrosine-protein kinase Fes/Fps isoform X2

    Conserved Domains (2) summary
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl12013
    Location:7 → 239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_003946388.1 RNA Sequence

    Related
    ENSMUST00000206744.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16879.2 GenPept UniProtKB/Swiss-Prot:P16879

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