Fem1a fem 1 homolog a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fem1aprovided by MGI
Official Full Name: fem 1 homolog aprovided by MGI
Primary source: MGI:MGI:1335089
See related: Ensembl:ENSMUSG00000043683 AllianceGenome:MGI:1335089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eprap; Fem1aa
Summary: Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of inflammatory response. Acts upstream of or within negative regulation of MAP kinase activity and negative regulation of inflammatory response. Located in mitochondrion. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; retina; and spleen. Orthologous to human FEM1A (fem-1 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.24 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56563793..56570608)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56256793..56263608)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunoprecipitation analyses demonstrated that EPRAP associated with PP2A in both MEFs and alveolar macrophages from BLM-treated mice.
Title: EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.
prostaglandin E2 type 4 receptor-associated protein promotes proinflammatory activation of microglia through mitogen-activated protein kinase kinase 4-mediated signaling and may be key to the deteriorating neuronal damage brought on by brain inflammation
Title: EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain.
PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation.
Title: Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.
Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis
Title: The Fem1a gene is downregulated in Rhabdomyosarcoma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048389 (e-PCR)
- UniSTS:109583

AW611390 (e-PCR)
- UniSTS:181047

NoName (e-PCR)
- UniSTS:237672

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables EP4 subtype prostaglandin E2 receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein fem-1 homolog A-A

Names: FEM1-alpha-A; FEM1a-A; feminization 1 homolog a; prostaglandin E receptor 4-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010192.4 → NP_034322.3 protein fem-1 homolog A-A

See identical proteins and their annotated locations for NP_034322.3

Status: VALIDATED

Source sequence(s)

AI021455, AK042461, AK080978, BC054382, BP757418, BY343573, CO426831

Consensus CDS

CCDS28899.1

UniProtKB/Swiss-Prot

Q3U2C2, Q8C4V3, Q8C6D9, Q8CBW9, Q9DBC6, Q9Z2G1

Related

ENSMUSP00000057996.4, ENSMUST00000060253.5

Conserved Domains (6) summary

smart00248
Location:43 → 70

ANK; ankyrin repeats

cd00204
Location:82 → 203

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:87 → 179

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:183 → 235

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:552 → 605

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:82 → 113

ANK; ANK repeat [structural motif]