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Fdxr ferredoxin reductase [ Mus musculus (house mouse) ]

Gene ID: 14149, updated on 21-Apr-2024

Summary

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Official Symbol
Fdxrprovided by MGI
Official Full Name
ferredoxin reductaseprovided by MGI
Primary source
MGI:MGI:104724
See related
Ensembl:ENSMUSG00000018861 AllianceGenome:MGI:104724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AR
Summary
Predicted to enable NADPH binding activity and NADPH-adrenodoxin reductase activity. Predicted to be involved in NADPH oxidation and ubiquinone biosynthetic process. Predicted to act upstream of or within cholesterol metabolic process. Located in mitochondrial inner membrane. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 647.4) and ovary adult (RPKM 88.8) See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115158850..115167925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115268024..115277101, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:115048516-115048817 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115088135-115088322 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115088428-115088537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115092913-115093101 Neighboring gene glutamate receptor, ionotropic, NMDA2C (epsilon 3) Neighboring gene STARR-positive B cell enhancer ABC_E44 Neighboring gene fatty acid desaturase domain family, member 6 Neighboring gene otopetrin 2 Neighboring gene USH1 protein network component sans

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrated analysis of the molecular pathogenesis of FDXR-associated disease. Slone JD, et al. Cell Death Dis, 2020 Jun 4. PMID 32499495, Free PMC Article
  2. Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced form of sheep ferredoxin reductase. Furukawa A, et al. Biol Reprod, 1997 May. PMID 9160736
  3. Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway. Zhang Y, et al. Oncogene, 2022 Mar. PMID 35121827, Free PMC Article
  4. FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression. Zhang J, et al. J Pathol, 2020 Jul. PMID 32304229, Free PMC Article
  5. Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. Slone J, et al. J Hum Genet, 2018 Dec. PMID 30250212, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
    Title: hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
  2. Integrated analysis of the molecular pathogenesis of FDXR-associated disease.
    Title: Integrated analysis of the molecular pathogenesis of FDXR-associated disease.
  3. FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
    Title: FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
  4. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment.
    Title: Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.
  5. FDXR and p53 are mutually regulated and that the FDXR-p53 loop is critical for tumor suppression via iron homeostasis.
    Title: Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH-adrenodoxin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH-adrenodoxin reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADPH:adrenodoxin oxidoreductase, mitochondrial
Names
adrenodoxin reductase
ferredoxin--NADP(+) reductase
NP_032023.1
XP_006532249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007997.1 → NP_032023.1  NADPH:adrenodoxin oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032023.1

    Status: VALIDATED

    Source sequence(s)
    D49920
    Consensus CDS
    CCDS25625.1
    UniProtKB/Swiss-Prot
    Q61578
    UniProtKB/TrEMBL
    Q6IQY0
    Related
    ENSMUSP00000021078.3, ENSMUST00000021078.3
    Conserved Domains (2) summary
    PLN02852
    Location:10 → 490
    PLN02852; ferredoxin-NADP+ reductase
    cl21454
    Location:42 → 73
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115158850..115167925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532186.5 → XP_006532249.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q6IQY0
    Conserved Domains (1) summary
    cl30539
    Location:10 → 472
    PLN02852; ferredoxin-NADP+ reductase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61578.1 GenPept UniProtKB/Swiss-Prot:Q61578

Gene LinkOut

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