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Fcgrt Fc fragment of IgG receptor and transporter [ Mus musculus (house mouse) ]

Gene ID: 14132, updated on 5-Mar-2024

Summary

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Official Symbol
Fcgrtprovided by MGI
Official Full Name
Fc fragment of IgG receptor and transporterprovided by MGI
Primary source
MGI:MGI:103017
See related
Ensembl:ENSMUSG00000003420 AllianceGenome:MGI:103017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FcRn
Summary
Predicted to enable IgG binding activity and beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; intestine; liver; sensory organ; and skeleton. Orthologous to human FCGRT (Fc fragment of IgG receptor and transporter). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 121.9), mammary gland adult (RPKM 87.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fcgrt in Genome Data Viewer
Location:
7 B3; 7 29.12 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44742417..44753246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45092993..45103822, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3, EF-hand calcium binding domain Neighboring gene STARR-seq mESC enhancer starr_18830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52376860-52377101 Neighboring gene predicted gene 45552 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene microRNA 150 Neighboring gene ribosomal protein S11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. Haddad G, et al. PLoS One, 2023. PMID 37071647, Free PMC Article
  2. A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studies. Conner CM, et al. Biochem Pharmacol, 2023 Apr. PMID 36870576
  3. DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Parzych EM, et al. Nat Commun, 2022 Oct 6. PMID 36202799, Free PMC Article
  4. Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. Grevys A, et al. iScience, 2022 Feb 18. PMID 35118359, Free PMC Article
  5. Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques. Pannek A, et al. Mol Biol Cell, 2022 Jan 1. PMID 34731029, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
    Title: Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
  2. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
    Title: Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
  3. Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
    Title: Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
  4. Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
    Title: Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
  5. FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
    Title: FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
  6. In podocytes, Fcgrt modulates the IL-6 mediated response to inflammatory stimuli and regulates podocytes actin structure.
    Title: Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
  7. The studies demonstrate a pivotal role for FcRn-mediated salvage in compensating for the high pinocytic and degradative activities of macrophages to maintain IgG homeostasis.
    Title: Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis.
  8. Knockout of FcRn leads to IgG accumulation in podocytes but does not alter albumin trafficking.
    Title: Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.
  9. These findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation.
    Title: Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.
  10. Low FcRN expression is associated with proteinuria.
    Title: Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (9) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc receptor, IgG, alpha chain transporter
igG Fc fragment receptor transporter alpha chain
neonatal Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357117.1 → NP_001344046.1  IgG receptor FcRn large subunit p51 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Consensus CDS
    CCDS90230.1
    UniProtKB/TrEMBL
    Q6PKB0
    Related
    ENSMUSP00000147496.2, ENSMUST00000210642.2
    Conserved Domains (2) summary
    cl08246
    Location:25 → 201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:205 → 292
    Ig; Immunoglobulin domain

  2. NM_010189.3 → NP_034319.2  IgG receptor FcRn large subunit p51 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034319.2

    Status: VALIDATED

    Source sequence(s)
    AK146933, AK152879, BY063885
    Consensus CDS
    CCDS52243.1
    UniProtKB/Swiss-Prot
    Q61559, Q9QUR0, Q9R2A5
    Related
    ENSMUSP00000003512.8, ENSMUST00000003512.9
    Conserved Domains (2) summary
    cl08246
    Location:25 → 197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:201 → 288
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44742417..44753246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61559.1 GenPept UniProtKB/Swiss-Prot:Q61559

Gene LinkOut

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