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Fcgr3 Fc receptor, IgG, low affinity III [ Mus musculus (house mouse) ]

Gene ID: 14131, updated on 22-Apr-2024

Summary

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Official Symbol
Fcgr3provided by MGI
Official Full Name
Fc receptor, IgG, low affinity IIIprovided by MGI
Primary source
MGI:MGI:95500
See related
Ensembl:ENSMUSG00000059498 AllianceGenome:MGI:95500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD16
Summary
Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc fragment of IgG receptor IIa). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 18.3), testis adult (RPKM 15.7) and 27 other tissues See more
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Genomic context

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Location:
1 H3; 1 78.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170878738..170893477, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171051169..171065915, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2585 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAG) Neighboring gene STARR-seq mESC enhancer starr_03010 Neighboring gene STARR-seq mESC enhancer starr_03011 Neighboring gene nuclear encoded tRNA glycine 4 (anticodon GCC) Neighboring gene STARR-seq mESC enhancer starr_03012 Neighboring gene nuclear encoded tRNA glutamic acid 5 (anticodon CTC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon TCC) Neighboring gene microRNA 6546 Neighboring gene nuclear encoded tRNA aspartic acid 3 (anticodon GTC) Neighboring gene nuclear encoded tRNA glycine 12 (anticodon GCC) Neighboring gene nuclear encoded tRNA leucine 6 (anticodon CAG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of FcγRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model. Rojas-Ortega DA, et al. Parasitol Res, 2023 May. PMID 36913025, Free PMC Article
  2. FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Qiu A, et al. Front Immunol, 2022. PMID 36189253, Free PMC Article
  3. Negative regulation of bacterial killing and inflammation by two novel CD16 ligands. Beppler J, et al. Eur J Immunol, 2016 Aug. PMID 27226142
  4. Imaging and measuring the biophysical properties of Fc gamma receptors on single macrophages using atomic force microscopy. Li M, et al. Biochem Biophys Res Commun, 2013 Sep 6. PMID 23916706
  5. Absence of FcγRIII results in increased proinflammatory response in FcγRIII-KO cardiac recipients. Erdinc Sunay MM, et al. Transplantation, 2013 Oct 15. PMID 23903009, Free PMC Article

See all (253) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5.
    Title: Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5.
  2. Impact of surface receptors TLR2, CR3, and FcgammaRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
    Title: Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
  3. Role of FcgammaRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model.
    Title: Role of FcγRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model.
  4. The CD3zeta adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
    Title: The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
  5. FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.
    Title: FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.
  6. Although enhanced humoral immune responses were observed in the absence of FcgammaRIIIA in the mouse asthma model, no overall regulation by FcgammaRIIIA, especially in terms of those parameters measuring lung tissue inflammation, was recorded. In the absence of FcgammaRIIB, augmented immune responses measured as serum antibody levels as well as those in various regulatory pathways in this mouse asthma model were observed.
    Title: FcγRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model.
  7. FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
    Title: Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes.
  8. PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor-mediated phagocytosis in macrophages.
    Title: Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
  9. Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression.
    Title: MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression.
  10. Fcgr3 resided in Kupffer cells, and it contributed to the inhibition of the growth of liver tumor cells.
    Title: Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (6) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IgG binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables IgG receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IgG receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables IgG receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antibody-dependent cellular cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mast cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mast cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis, recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within serotonin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
low affinity immunoglobulin gamma Fc region receptor III
Names
Fc gamma receptor III
Fcg receptor III
FcgammaRIII
fc-gamma RIII
fcRIII
igG Fc receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356511.2 → NP_001343440.1  low affinity immunoglobulin gamma Fc region receptor III isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115959, AC117796
    Consensus CDS
    CCDS87919.1
    UniProtKB/TrEMBL
    E9PUV2, Q9ES92
    Related
    ENSMUSP00000131836.2, ENSMUST00000169017.8
    Conserved Domains (2) summary
    cd05753
    Location:122 → 204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:40 → 118
    Ig; Immunoglobulin domain

  2. NM_001405018.1 → NP_001391947.1  low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115959, AC117796
    UniProtKB/TrEMBL
    A0A0B4J1M6

  3. NM_001405019.1 → NP_001391948.1  low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115959, AC117796
    UniProtKB/TrEMBL
    A0A0B4J1M6

  4. NM_010188.5 → NP_034318.2  low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

    See identical proteins and their annotated locations for NP_034318.2

    Status: VALIDATED

    Source sequence(s)
    AC115959, AK151557, BY199827
    Consensus CDS
    CCDS15477.2
    UniProtKB/TrEMBL
    A0A0B4J1M6, Q9ES92
    Related
    ENSMUSP00000131938.2, ENSMUST00000164044.8
    Conserved Domains (2) summary
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41 → 119
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170878738..170893477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496659.5 → XP_006496722.1  low affinity immunoglobulin gamma Fc region receptor III isoform X1

    See identical proteins and their annotated locations for XP_006496722.1

    UniProtKB/TrEMBL
    A0A0B4J1M6, Q9ES92
    Conserved Domains (2) summary
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41 → 119
    Ig; Immunoglobulin domain

  2. XM_030247708.1 → XP_030103568.1  low affinity immunoglobulin gamma Fc region receptor III isoform X1

    UniProtKB/TrEMBL
    A0A0B4J1M6, Q9ES92
    Conserved Domains (2) summary
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41 → 119
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08508.1 GenPept UniProtKB/Swiss-Prot:P08508

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