Fcgr1 Fc receptor, IgG, high affinity I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgr1provided by MGI
Official Full Name: Fc receptor, IgG, high affinity Iprovided by MGI
Primary source: MGI:MGI:95498
See related: Ensembl:ENSMUSG00000015947 AllianceGenome:MGI:95498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD64; IGGHAFC; FcgammaRI
Summary: Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; endocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 4.7), liver E14 (RPKM 2.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 41.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96190225..96201285, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96282909..96293969, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD64 plays a key role in diabetic wound healing.
Title: CD64 plays a key role in diabetic wound healing.
Sensory Neuron Expressed FcgammaRI Mediates Postinflammatory Arthritis Pain in Female Mice.
Title: Sensory Neuron Expressed FcγRI Mediates Postinflammatory Arthritis Pain in Female Mice.
Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice.
Title: Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice.
FcgammaRI expressed in sensory neurons contributes to arthritis pain in a mouse model, independently of its functions in inflammatory cells
Title: Neuronal FcγRI mediates acute and chronic joint pain.
The FcgammaR-binding affinity of mIgG1 is under the control of glycosylation.
Title: FcγR-binding affinity of monoclonal murine IgG1s carrying different N-linked Fc oligosaccharides.
this study shows that FcRgamma deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway
Title: FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.
Opsonization by Friend virus-specific non-neutralizing IgG abrogated DC infection and as a consequence significantly reduced the capacity of Dendritic cells (DCs) to activate virus-specific CD8 T cells. Effects of IgG-opsonization were mediated by the high-affinity FcgammaR type I, CD64, expressed on DCs.
Title: Fcγ Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus.
FcgammaRI plays a role on macrophages to involve in renal inflammatory response, potentially via regulating the NLRP3 inflammasome-associated signaling.
Title: Lentivirus-mediated knockdown of FcγRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice.
investigated consequences of 3 nonsynonymous SNPs for FcgammaRI; only SNP V39I reduces immune-complex binding of FcgammaRI whereas monomeric IgG binding is unaffected; SNPs I301M and I338T have no influence on monomeric IgG or immune complex binding, but FcRgamma signaling is decreased for both SNPs
Title: Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.
FcgammaRI/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP) than in the Treg-deficient non-ITP and control mice
Title: Mouse immune thrombocytopenia is associated with Th1 bias and expression of activating Fcγ receptors.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234763

D3Nds11 (e-PCR), detects polymorphism
- UniSTS:142401

D3Nds11 (e-PCR), detects polymorphism
- UniSTS:142402

AI323638 (e-PCR)
- UniSTS:165275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgG binding	IDA Inferred from Direct Assay more info	PubMed
enables IgG binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables high-affinity IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables leukotriene receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type III hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity immunoglobulin gamma Fc receptor I

Names: IgG high affinity Fc receptor; fc-gamma RI; fcRI; igG Fc receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010186.5 → NP_034316.1 high affinity immunoglobulin gamma Fc receptor I precursor

See identical proteins and their annotated locations for NP_034316.1

Status: PROVISIONAL

Source sequence(s)

AC093350

Consensus CDS

CCDS17639.1

UniProtKB/Swiss-Prot

P26151

Related

ENSMUSP00000029748.4, ENSMUST00000029748.8

Conserved Domains (4) summary

cd05752
Location:32 → 110

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:125 → 194

IG_like; Immunoglobulin like

pfam00047
Location:205 → 283

ig; Immunoglobulin domain

cl11960
Location:114 → 194

Ig; Immunoglobulin domain