Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ms4a2provided by MGI
Official Full Name: membrane-spanning 4-domains, subfamily A, member 2provided by MGI
Primary source: MGI:MGI:95495
See related: Ensembl:ENSMUSG00000024680 AllianceGenome:MGI:95495
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FcRB; Fce1b; Ms4a1; fcERI; Fcer1b; Fcrbeta
Summary: This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11592881..11601154, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11615517..11623790, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that PU.1 and LDB1 play central roles in the formation of active chromatin structure whereas GATA2 directly activates the Ms4a2 promoter.
Title: GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms.
Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor beta chain polymorphic proteins has been presented.
Title: Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor β chain polymorphic proteins.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor.
Title: SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
These observations strongly suggest a novel signaling pathway mediated by the cytoplasmic tail downstream of the FcepsilonRIbeta immunoreceptor tyrosine-based activation motif.
Title: FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain.
FcRbeta is a critical element in mast cell synergistic degranulation response through FcepsilonRI & adenosine receptors. PI3K-signaling through FcRbeta-ITAM is a crucial participant in augmentation of FcepsilonRI-mediated degranulation by adenosine.
Title: FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors.
inhibition of FcepsilonRI-dependent mast cell activation can suppress allergic contact dermatitis
Title: Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone.
IgE signaling suppresses FcepsilonRIbeta expression.
Title: IgE signaling suppresses FcepsilonRIbeta expression.
FcepsilonRI beta-chain regulates calcium uptake in mast cells via the immunoreceptor tyrosine-based activation motif.
Title: The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif.
IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI was expressed in cultured dorsal root ganglion cells.
Title: Expression of Fc epsilon receptor I on primary sensory neurons in mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

J05019 (e-PCR)
- UniSTS:163608

Ms4a2 (e-PCR), detects polymorphism
- UniSTS:527043

J05019 (e-PCR)
- UniSTS:181203

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to IgE binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fc-epsilon receptor I complex	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit beta

Names: Fc receptor, IgE, high affinity I, beta polypeptide; fc epsilon receptor I beta-chain; membrane-spanning 4-domains, subfamily A, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276328.1 → NP_001263257.1 high affinity immunoglobulin epsilon receptor subunit beta isoform b

See identical proteins and their annotated locations for NP_001263257.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AK144021, AK161121, BY585879

Consensus CDS

CCDS70936.1

UniProtKB/TrEMBL

Q3UNT6

Related

ENSMUSP00000025583.6, ENSMUST00000025583.12

Conserved Domains (1) summary

pfam04103
Location:52 → 156

CD20; CD20-like family
NM_001276329.1 → NP_001263258.1 high affinity immunoglobulin epsilon receptor subunit beta isoform c

See identical proteins and their annotated locations for NP_001263258.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AK144021, AK161121, BY585879

Consensus CDS

CCDS79695.1

UniProtKB/TrEMBL

A0A0B4J1P0

Related

ENSMUSP00000140628.2, ENSMUST00000186978.7
NM_001276330.1 → NP_001263259.1 high affinity immunoglobulin epsilon receptor subunit beta isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame exon and includes an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AK161121, BB847820, BY585879, CN663232

Consensus CDS

CCDS79694.1

UniProtKB/TrEMBL

A0A087WPM9

Related

ENSMUSP00000139841.2, ENSMUST00000189641.2

Conserved Domains (1) summary

pfam04103
Location:52 → 160

CD20; CD20-like family
NM_013516.2 → NP_038544.1 high affinity immunoglobulin epsilon receptor subunit beta isoform a

See identical proteins and their annotated locations for NP_038544.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK144021, AK161121, BC139323, BY585879

Consensus CDS

CCDS29604.1

UniProtKB/Swiss-Prot

P20490

UniProtKB/TrEMBL

B2RTF7

Related

ENSMUSP00000127373.2, ENSMUST00000164792.8

Conserved Domains (1) summary

pfam04103
Location:52 → 192

CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

11592881..11601154 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318060.1 → XP_017173549.1 high affinity immunoglobulin epsilon receptor subunit beta isoform X1

Conserved Domains (1) summary

pfam04103
Location:55 → 150

CD20; CD20-like family