Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcer1aprovided by MGI
Official Full Name: Fc receptor, IgE, high affinity I, alpha polypeptideprovided by MGI
Primary source: MGI:MGI:95494
See related: Ensembl:ENSMUSG00000005339 AllianceGenome:MGI:95494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FcERI; Fce1a; Fcr-5; fcepsilonri
Summary: Enables IgE binding activity and IgE receptor activity. Acts upstream of or within several processes, including leukotriene biosynthetic process; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human FCER1A (Fc fragment of IgE receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 80.33 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173048836..173054799, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173221269..173227232, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcepsilonRIalpha.
Title: A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα.
IRF3 Activation in Mast Cells Promotes FcepsilonRI-Mediated Allergic Inflammation.
Title: IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation.
Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells.
Title: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.
House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcepsilonRIalpha.
Title: House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα.
this study shows that mast cells co-cultured with macrophages alter protein expression of both cell types, and that mast cells transfer FceRI-encompassed cellular regions directly to macrophages during Francisella tularensis
Title: Contribution of FcɛRI-associated vesicles to mast cell-macrophage communication following Francisella tularensis infection.
Tim-3 acts at a receptor-proximal point to enhance Lyn kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI ligation.
Title: Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation.
Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma).
Title: Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.
Conferring expression of FcepsilonRI to dendritic cells decreases the severity of food allergy and asthma in disease-relevant models suggesting anti-inflammatory IgE/FcepsilonRI signals.
Title: Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
IgE-mediated activation of dendritic cells via IgE receptors binding in allergic Th2-type inflammation appears to be immune regulatory rather than pro-inflammatory. (Review)
Title: Functions of dendritic-cell-bound IgE in allergy.
Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
Title: Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494127

NoName (e-PCR)
- UniSTS:489127

Fcer1a (e-PCR), detects polymorphism
- UniSTS:143081

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgE binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgE binding	IDA Inferred from Direct Assay more info	PubMed
enables IgE binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables IgE receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables IgE receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables high-affinity IgE receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables high-affinity IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eosinophil degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of interleukin-3 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukotriene biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-3 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in type I hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit alpha

Names: fc-epsilon RI-alpha; igE Fc receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010184.2 → NP_034314.2 high affinity immunoglobulin epsilon receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_034314.2

Status: VALIDATED

Source sequence(s)

BC125455, BY585428, CJ142154, CJ142191, J05018

Consensus CDS

CCDS35788.1

UniProtKB/Swiss-Prot

E9QLR4, P20489

Related

ENSMUSP00000056882.6, ENSMUST00000049706.11

Conserved Domains (2) summary

cd00096
Location:45 → 49

Ig; Ig strand B [structural motif]

cl11960
Location:28 → 107

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

173048836..173054799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496655.1 → XP_006496718.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform X1

Conserved Domains (1) summary

cl11960
Location:104 → 185

Ig; Immunoglobulin domain