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Dclre1b DNA cross-link repair 1B [ Mus musculus (house mouse) ]

Gene ID: 140917, updated on 5-Mar-2024

Summary

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Official Symbol
Dclre1bprovided by MGI
Official Full Name
DNA cross-link repair 1Bprovided by MGI
Primary source
MGI:MGI:2156057
See related
Ensembl:ENSMUSG00000027845 AllianceGenome:MGI:2156057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNMIB; Apollo; mSNM1B
Summary
Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in brain. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 4.1), liver E14 (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103707921..103716703, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103800605..103809387, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103542020-103542203 Neighboring gene STARR-positive B cell enhancer ABC_E6093 Neighboring gene olfactomedin-like 3 Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103577942-103578125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103581922-103582188 Neighboring gene predicted gene 15886 Neighboring gene STARR-positive B cell enhancer ABC_E11207 Neighboring gene predicted gene 15471 Neighboring gene adaptor-related protein complex AP-4, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E7934 Neighboring gene STARR-seq mESC enhancer starr_08603 Neighboring gene BCLl2-like 15 Neighboring gene STARR-positive B cell enhancer ABC_E3458 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103663204-103663387 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103664081-103664275 Neighboring gene STARR-positive B cell enhancer ABC_E6094 Neighboring gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Neighboring gene STARR-positive B cell enhancer ABC_E2090 Neighboring gene STARR-seq mESC enhancer starr_08604

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. Lam YC, et al. EMBO J, 2010 Jul 7. PMID 20551906, Free PMC Article
  2. Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Wu P, et al. Cell, 2012 Jul 6. PMID 22748632, Free PMC Article
  3. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Akhter S, et al. Aging Cell, 2010 Dec. PMID 20854421, Free PMC Article
  4. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Wu P, et al. Mol Cell, 2010 Aug 27. PMID 20619712, Free PMC Article
  5. SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Akhter S, et al. Biochem Biophys Res Commun, 2008 Dec 5. PMID 18848520, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
    Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
  2. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development
    Title: The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
  3. TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.
    Title: Apollo contributes to G overhang maintenance and protects leading-end telomeres.
  4. Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
    Title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-lactamase activity ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide-excision repair ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in telomeric 3' overhang formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomeric loop formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
5' exonuclease Apollo
Names
DNA cross-link repair 1B protein
DNA cross-link repair 1B, PSO2 homolog
SNM1 homolog B
beta-lactamase MBLAC2
NP_001020483.1
NP_598626.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025312.1 → NP_001020483.1  5' exonuclease Apollo isoform b

    See identical proteins and their annotated locations for NP_001020483.1

    Status: VALIDATED

    Source sequence(s)
    BC067017, BQ559794, CA317555
    Consensus CDS
    CCDS17695.1
    UniProtKB/Swiss-Prot
    Q8C7W7
    Related
    ENSMUSP00000067695.7, ENSMUST00000063502.13
    Conserved Domains (3) summary
    cd11662
    Location:366 → 398
    apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins
    pfam07522
    Location:90 → 172
    DRMBL; DNA repair metallo-beta-lactamase
    cl23716
    Location:1 → 25
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  2. NM_133865.2 → NP_598626.2  5' exonuclease Apollo isoform a

    See identical proteins and their annotated locations for NP_598626.2

    Status: VALIDATED

    Source sequence(s)
    AK049115, AK084347, BC067017, CA548899
    Consensus CDS
    CCDS17694.1
    UniProtKB/Swiss-Prot
    A0JLW2, B0V3N9, B0V3P0, Q3U4P2, Q3UUC7, Q3UV92, Q6NXL4, Q8BN95, Q8BQS8, Q8C7W7, Q921S0
    Related
    ENSMUSP00000029435.9, ENSMUST00000029435.15
    Conserved Domains (3) summary
    cd11662
    Location:492 → 524
    apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins
    pfam07522
    Location:216 → 298
    DRMBL; DNA repair metallo-beta-lactamase
    cd16273
    Location:6 → 151
    SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103707921..103716703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C7W7.2 GenPept UniProtKB/Swiss-Prot:Q8C7W7

Gene LinkOut

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