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Lnx2 ligand of numb-protein X 2 [ Mus musculus (house mouse) ]

Gene ID: 140887, updated on 21-Apr-2024

Summary

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Official Symbol
Lnx2provided by MGI
Official Full Name
ligand of numb-protein X 2provided by MGI
Primary source
MGI:MGI:2155959
See related
Ensembl:ENSMUSG00000016520 AllianceGenome:MGI:2155959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630046H24
Summary
Enables PDZ domain binding activity and identical protein binding activity. Is expressed in several structures, including brain; cardiovascular system; hemolymphoid system gland; liver; and lung. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 17.5), ovary adult (RPKM 17.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G3; 5 86.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146953471..147013364, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147016655..147076572, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10366 Neighboring gene STARR-seq mESC enhancer starr_14863 Neighboring gene general transcription factor III A Neighboring gene STARR-seq mESC enhancer starr_14864 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene predicted gene, 46936 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184 Neighboring gene STARR-positive B cell enhancer ABC_E8092 Neighboring gene polymerase (RNA) I polypeptide D Neighboring gene ribosomal protein S10, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_14868 Neighboring gene predicted gene, 34994

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos. Lee SJ, et al. Int J Mol Sci, 2023 Jan 10. PMID 36674899, Free PMC Article
  2. Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Zhou J, et al. Calcif Tissue Int, 2015 May. PMID 25712254, Free PMC Article
  3. The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2). Mirza M, et al. Exp Cell Res, 2005 Sep 10. PMID 15979067
  4. Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells. Yin FT, et al. Stem Cells Dev, 2015 Mar 1. PMID 25279559, Free PMC Article
  5. Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis. Mirza M, et al. Exp Cell Res, 2006 Apr 1. PMID 16410001

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos.
    Title: Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos.
  2. conclude that LNX2 regulates M-CSF/RANKL and the Notch signaling pathways during osteoclastogenesis
    Title: Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.
  3. Caspr4 inhibits neuronal differentiation in a LNX-dependent manner.
    Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
  4. coxsackievirus and adenovirus receptor is a partner in a protein complex organized at specific subcellular sites by LNX2
    Title: The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ligand of Numb protein X 2
Names
numb-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424753.1 → NP_001411682.1  ligand of Numb protein X 2

    Status: VALIDATED

    Source sequence(s)
    AL513345
    UniProtKB/Swiss-Prot
    A6PW04, Q8CBE1, Q91XL2

  2. NM_001424754.1 → NP_001411683.1  ligand of Numb protein X 2

    Status: VALIDATED

    Source sequence(s)
    AL513345
    UniProtKB/Swiss-Prot
    A6PW04, Q8CBE1, Q91XL2

  3. NM_080795.5 → NP_542985.4  ligand of Numb protein X 2

    See identical proteins and their annotated locations for NP_542985.4

    Status: VALIDATED

    Source sequence(s)
    AL513345
    Consensus CDS
    CCDS19875.1
    UniProtKB/Swiss-Prot
    A6PW04, Q8CBE1, Q91XL2
    UniProtKB/TrEMBL
    Q0VGP5, Q148W6
    Related
    ENSMUSP00000016664.8, ENSMUST00000016664.8
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:596 → 680
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

RNA

  1. NR_188904.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL513345

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146953471..147013364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504800.4 → XP_006504863.1  ligand of Numb protein X 2 isoform X1

    See identical proteins and their annotated locations for XP_006504863.1

    UniProtKB/Swiss-Prot
    A6PW04, Q8CBE1, Q91XL2
    UniProtKB/TrEMBL
    Q0VGP5, Q148W6
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:596 → 680
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XL2.2 GenPept UniProtKB/Swiss-Prot:Q91XL2

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