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P2ry14 purinergic receptor P2Y, G-protein coupled, 14 [ Mus musculus (house mouse) ]

Gene ID: 140795, updated on 16-Apr-2024

Summary

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Official Symbol
P2ry14provided by MGI
Official Full Name
purinergic receptor P2Y, G-protein coupled, 14provided by MGI
Primary source
MGI:MGI:2155705
See related
Ensembl:ENSMUSG00000036381 AllianceGenome:MGI:2155705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2Y14; Gpr105; A330108O13Rik
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human P2RY14 (purinergic receptor P2Y14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 13.2), large intestine adult (RPKM 3.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 D; 3 28.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59022044..59060913, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59114623..59153492, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene mediator complex subunit 12-like Neighboring gene STARR-positive B cell enhancer ABC_E6054 Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils. Liu C, et al. Front Immunol, 2022. PMID 35432308, Free PMC Article
  2. Role of UDP-Sugar Receptor P2Y(14) in Murine Osteoblasts. Mikolajewicz N, et al. Int J Mol Sci, 2020 Apr 15. PMID 32326617, Free PMC Article
  3. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. Battistone MA, et al. J Clin Invest, 2020 Jul 1. PMID 32287042, Free PMC Article
  4. P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures. Curet MA, et al. J Neurooncol, 2018 Mar. PMID 29189936, Free PMC Article
  5. The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice. Meister J, et al. J Biol Chem, 2014 Aug 22. PMID 24993824, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils.
    Title: GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils.
  2. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
    Title: The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
  3. UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
    Title: UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.
  4. Role of UDP-Sugar Receptor P2Y14 in Murine Osteoblasts.
    Title: Role of UDP-Sugar Receptor P2Y(14) in Murine Osteoblasts.
  5. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
    Title: Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
  6. P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures. These data suggest that P2Y14 receptors may be a key a receptor involved in glioma cell-microglial/macrophage communication in the tumor environment.
    Title: P2Y14 receptor activation decreases interleukin-6 production and glioma GL261 cell proliferation in microglial transwell cultures.
  7. Present study suggests that P2Y14 expression could be used as a phenotypic marker to further dissect placental HSPCs.
    Title: The expression of P2Y14, a purinergic G-protein coupled receptor, defines functionally distinct subpopulations in placenta-derived hematopoietic stem progenitor cells.
  8. Insulin secretion tests revealed a reduced insulin release from P2Y14-deficient islets, highlighting P2Y14 as a new modulator of proper insulin secretion
    Title: The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.
  9. the physiological importance of P2Y14 receptors in the vasculature
    Title: Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries.
  10. P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitoring and responding to the extracellular manifestations of tissue stress
    Title: Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 14
Names
G-protein coupled receptor 105
UDP-glucose receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008497.2 → NP_001008497.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001008497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AC115919, AK164982, BC058558
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Related
    ENSMUSP00000066669.7, ENSMUST00000065220.13
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001287119.1 → NP_001274048.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001274048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AC115919
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Related
    ENSMUSP00000142601.2, ENSMUST00000196081.5
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_001287120.1 → NP_001274049.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001274049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AK164982, BY177387
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. NM_001287121.1 → NP_001274050.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001274050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AK039791, AK164982, CF169635
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  5. NM_001287122.1 → NP_001274051.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001274051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AK164982, CK622172
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  6. NM_001287123.1 → NP_001274052.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_001274052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein (isoform a).
    Source sequence(s)
    AK039791, AK164982
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Related
    ENSMUSP00000143070.2, ENSMUST00000197220.2
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  7. NM_001287124.1 → NP_001274053.1  P2Y purinoceptor 14 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 3' terminal exon which results in a distinct 5' UTR and causes translation initiation at an upstream start codon compared to variant 1. It encodes isoform b which is longer and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC115919
    Consensus CDS
    CCDS79913.1
    UniProtKB/TrEMBL
    A0A0G2JEW9
    Related
    ENSMUSP00000142934.2, ENSMUST00000197841.2
    Conserved Domains (1) summary
    pfam00001
    Location:49 → 304
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  8. NM_133200.4 → NP_573463.1  P2Y purinoceptor 14 isoform a

    See identical proteins and their annotated locations for NP_573463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (a). Variants 1 through 7 encode the same protein.
    Source sequence(s)
    AC115919, AK164982
    Consensus CDS
    CCDS17371.1
    UniProtKB/Swiss-Prot
    Q9ESG6
    UniProtKB/TrEMBL
    Q544F4
    Related
    ENSMUSP00000088642.5, ENSMUST00000091112.6
    Conserved Domains (1) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    59022044..59060913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESG6.1 GenPept UniProtKB/Swiss-Prot:Q9ESG6

Gene LinkOut

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