Fabp3 fatty acid binding protein 3, muscle and heart [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fabp3provided by MGI
Official Full Name: fatty acid binding protein 3, muscle and heartprovided by MGI
Primary source: MGI:MGI:95476
See related: Ensembl:ENSMUSG00000028773 AllianceGenome:MGI:95476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mdgi; Fabph1; Fabph4; H-FABP; Fabph-1; Fabph-4
Summary: Predicted to enable cytoskeletal protein binding activity; fatty acid binding activity; and long-chain fatty acid transporter activity. Involved in several processes, including lipid homeostasis; lipid transport; and positive regulation of long-chain fatty acid import into cell. Acts upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 2334.3) and placenta adult (RPKM 178.9) See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.43 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (130202531..130209256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (130308738..130315463)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
Title: Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Title: Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Changes in median eminence of fatty acid-binding protein 3 in a mouse model of pain.
Title: Changes in median eminence of fatty acid-binding protein 3 in a mouse model of pain.
Suppression of alpha-synuclein propagation after intrastriatal injection in FABP3 null mice.
Title: Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice.
Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice.
Title: Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice.
Fatty acid-binding protein 3 regulates differentiation of IgM-producing plasma cells.
Title: Fatty acid-binding protein 3 regulates differentiation of IgM-producing plasma cells.
Crucial Role of FABP3 in alphaSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.
Title: Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.
FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.
Title: FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.
FABP3 is critical for alpha-Synuclein uptake in dopaminergic neurons, thereby preventing synucleinopathies, including Parkinson's disease.
Title: Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP(+)-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons.
Deficiency of FABP3 protects cardiac myocytes from apoptosis and alleviates cardiac remodeling after myocardial infarction.
Title: Fatty acid-binding protein 3 contributes to ischemic heart injury by regulating cardiac myocyte apoptosis and MAPK pathways.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fabp3 (e-PCR), detects polymorphism
- UniSTS:498469

Fabp3 (e-PCR), detects polymorphism
- UniSTS:498376

U02884 (e-PCR)
- UniSTS:125642

Fabp3 (e-PCR), detects polymorphism
- UniSTS:143061

Fabp3 (e-PCR), detects polymorphism
- UniSTS:143062

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables icosatetraenoic acid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oleic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipid biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylcholine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fatty acid-binding protein, heart

Names: fatty acid binding protein heart 1; fatty acid binding protein heart 4; fatty acid-binding protein 3; heart-type fatty acid-binding protein; mammary-derived growth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.