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TMEM37 transmembrane protein 37 [ Homo sapiens (human) ]

Gene ID: 140738, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM37provided by HGNC
Official Full Name
transmembrane protein 37provided by HGNC
Primary source
HGNC:HGNC:18216
See related
Ensembl:ENSG00000171227 MIM:618831; AllianceGenome:HGNC:18216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR; PR1
Summary
Predicted to enable calcium channel activity and voltage-gated ion channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 36.6), fat (RPKM 26.3) and 17 other tissues See more
Orthologs
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Genomic context

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See TMEM37 in Genome Data Viewer
Location:
2q14.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119429895..119438504)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119863369..119871962)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120189430..120196080)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene STEAP3 metalloreductase Neighboring gene uncharacterized LOC105373581 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120049626-120050127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120051788-120052288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120052289-120052789 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120064909-120065410 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene secretin receptor Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family of gamma-like calcium channel subunits. Klugbauer N, et al. FEBS Lett, 2000 Mar 24. PMID 10734232
  2. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
  3. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. Lin CW, et al. J Drug Target, 2012 Jul. PMID 22632162
  4. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article
  5. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of transmembrane protein 37 (TMEM37) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel gamma-like subunit
Names
neuronal voltage-gated calcium channel gamma-like subunit
voltage-dependent calcium channel gamma subunit-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183240.3 → NP_899063.2  voltage-dependent calcium channel gamma-like subunit

    See identical proteins and their annotated locations for NP_899063.2

    Status: VALIDATED

    Source sequence(s)
    AC013275, DR003856, DR005637
    Consensus CDS
    CCDS33281.1
    UniProtKB/Swiss-Prot
    Q8WXS4
    Related
    ENSP00000303148.4, ENST00000306406.5
    Conserved Domains (1) summary
    pfam15108
    Location:8 → 187
    TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119429895..119438504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510659.3 → XP_011508961.1  voltage-dependent calcium channel gamma-like subunit isoform X1

    UniProtKB/TrEMBL
    E7EMC0
    Related
    ENSP00000387015.1, ENST00000409826.1
    Conserved Domains (1) summary
    pfam15108
    Location:20 → 199
    TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

  2. XM_047443445.1 → XP_047299401.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    UniProtKB/TrEMBL
    Q86SV2

  3. XM_006712300.4 → XP_006712363.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    See identical proteins and their annotated locations for XP_006712363.1

    UniProtKB/TrEMBL
    Q86SV2
    Conserved Domains (1) summary
    pfam15108
    Location:1 → 100
    TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

  4. XM_047443446.1 → XP_047299402.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    UniProtKB/TrEMBL
    Q86SV2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119863369..119871962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340635.1 → XP_054196610.1  voltage-dependent calcium channel gamma-like subunit isoform X1

    UniProtKB/TrEMBL
    E7EMC0

  2. XM_054340636.1 → XP_054196611.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    UniProtKB/TrEMBL
    Q86SV2

  3. XM_054340637.1 → XP_054196612.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    UniProtKB/TrEMBL
    Q86SV2

  4. XM_054340638.1 → XP_054196613.1  voltage-dependent calcium channel gamma-like subunit isoform X2

    UniProtKB/TrEMBL
    Q86SV2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXS4.2 GenPept UniProtKB/Swiss-Prot:Q8WXS4

Gene LinkOut

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