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Cacng5 calcium channel, voltage-dependent, gamma subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 140723, updated on 5-Mar-2024

Summary

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Official Symbol
Cacng5provided by MGI
Official Full Name
calcium channel, voltage-dependent, gamma subunit 5provided by MGI
Primary source
MGI:MGI:2157946
See related
Ensembl:ENSMUSG00000040373 AllianceGenome:MGI:2157946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable channel regulator activity and voltage-gated calcium channel activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, postsynaptic endosome to lysosome; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of neurotransmitter receptor activity. Predicted to be located in postsynaptic density. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in nervous system and retina. Orthologous to human CACNG5 (calcium voltage-gated channel auxiliary subunit gamma 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.8), cerebellum adult (RPKM 5.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 70.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107765431..107805881, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107874604..107915055, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 1 Neighboring gene VISTA enhancer mm1348 Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene predicted gene 11650 Neighboring gene STARR-seq mESC enhancer starr_30997 Neighboring gene STARR-seq mESC enhancer starr_30998 Neighboring gene protein kinase C, alpha Neighboring gene predicted gene 11657 Neighboring gene microRNA 7223 Neighboring gene predicted gene, 51922

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. Kato AS, et al. J Neurosci, 2007 May 2. PMID 17475805, Free PMC Article
  2. The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. Moss FJ, et al. EMBO J, 2002 Apr 2. PMID 11927536, Free PMC Article
  3. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Burgess DL, et al. Genome Res, 1999 Dec. PMID 10613843, Free PMC Article
  4. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
  5. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Zhang CL, et al. Genes Dev, 2006 May 15. PMID 16702404, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel gamma-5 subunit
Names
TARP gamma-5
neuronal voltage-gated calcium channel gamma-5 subunit
transmembrane AMPAR regulatory protein gamma-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199301.1 → NP_001186230.1  voltage-dependent calcium channel gamma-5 subunit

    See identical proteins and their annotated locations for NP_001186230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK032548, AK034065
    Consensus CDS
    CCDS25572.1
    UniProtKB/Swiss-Prot
    Q8VHW4
    UniProtKB/TrEMBL
    Q544Q4, Q8R4I0
    Related
    ENSMUSP00000047888.3, ENSMUST00000039071.3
    Conserved Domains (1) summary
    cl21598
    Location:18 → 195
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_080644.3 → NP_542375.1  voltage-dependent calcium channel gamma-5 subunit

    See identical proteins and their annotated locations for NP_542375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK032548
    Consensus CDS
    CCDS25572.1
    UniProtKB/Swiss-Prot
    Q8VHW4
    UniProtKB/TrEMBL
    Q544Q4, Q8R4I0
    Related
    ENSMUSP00000102353.2, ENSMUST00000106742.8
    Conserved Domains (1) summary
    cl21598
    Location:18 → 195
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    107765431..107805881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248720.3 → XP_011247022.1  voltage-dependent calcium channel gamma-5 subunit isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:57 → 110
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHW4.1 GenPept UniProtKB/Swiss-Prot:Q8VHW4

Gene LinkOut

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