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Caskin2 CASK-interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 140721, updated on 5-Mar-2024

Summary

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Official Symbol
Caskin2provided by MGI
Official Full Name
CASK-interacting protein 2provided by MGI
Primary source
MGI:MGI:2157062
See related
Ensembl:ENSMUSG00000034471 AllianceGenome:MGI:2157062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1139; 1600028L06Rik
Summary
Predicted to be located in cytoplasm. Predicted to be active in membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CASKIN2 (CASK interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 50.9), lung adult (RPKM 48.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.91 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115689813..115704517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115798987..115813658, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene predicted gene, 46302 Neighboring gene microRNA 5621 Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene LLGL2 scribble cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_31178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Bencsik N, et al. Sci Rep, 2019 Nov 14. PMID 31727973, Free PMC Article
  2. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. Tabuchi K, et al. J Neurosci, 2002 Jun 1. PMID 12040031, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
    Title: Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
caskin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080643.2 → NP_542374.2  caskin-2

    See identical proteins and their annotated locations for NP_542374.2

    Status: VALIDATED

    Source sequence(s)
    BC053083
    Consensus CDS
    CCDS25647.1
    UniProtKB/Swiss-Prot
    B1ATA2, Q6ZPX1, Q7TS77, Q8VHK1
    Related
    ENSMUSP00000041328.5, ENSMUST00000041684.11
    Conserved Domains (10) summary
    cd09497
    Location:487 → 552
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:553 → 623
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:561 → 620
    SAM; Sterile alpha motif
    cd12063
    Location:284 → 345
    SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
    cd00204
    Location:76 → 209
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:152 → 251
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 61
    Ank_4; Ankyrin repeats (many copies)
    pfam16632
    Location:1144 → 1201
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:797 → 881
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:114 → 145
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115689813..115704517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248719.4 → XP_011247021.1  caskin-2 isoform X3

    Conserved Domains (9) summary
    cd09497
    Location:355 → 420
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:421 → 491
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12063
    Location:152 → 213
    SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
    PHA03247
    Location:529 → 975
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:18 → 54
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:20 → 119
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:266 → 293
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1012 → 1069
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:665 → 749
    Caskin-Pro-rich; Proline rich region of Caskin proteins

  2. XM_030245554.2 → XP_030101414.1  caskin-2 isoform X2

    Conserved Domains (9) summary
    cd09497
    Location:405 → 470
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:471 → 541
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12063
    Location:202 → 263
    SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
    PHA03247
    Location:579 → 1025
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:32 → 63
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:70 → 169
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:316 → 343
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1062 → 1119
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:715 → 799
    Caskin-Pro-rich; Proline rich region of Caskin proteins

  3. XM_030245555.2 → XP_030101415.1  caskin-2 isoform X3

    Conserved Domains (9) summary
    cd09497
    Location:355 → 420
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:421 → 491
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12063
    Location:152 → 213
    SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
    PHA03247
    Location:529 → 975
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:18 → 54
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:20 → 119
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:266 → 293
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1012 → 1069
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:665 → 749
    Caskin-Pro-rich; Proline rich region of Caskin proteins

  4. XM_006532181.5 → XP_006532244.1  caskin-2 isoform X1

    Conserved Domains (10) summary
    cd09497
    Location:466 → 531
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:532 → 602
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12063
    Location:263 → 324
    SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
    PHA03247
    Location:640 → 1086
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:57 → 192
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:93 → 124
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:131 → 230
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:377 → 404
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1123 → 1180
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:776 → 860
    Caskin-Pro-rich; Proline rich region of Caskin proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHK1.3 GenPept UniProtKB/Swiss-Prot:Q8VHK1

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