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Col26a1 collagen, type XXVI, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 140709, updated on 5-Mar-2024

Summary

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Official Symbol
Col26a1provided by MGI
Official Full Name
collagen, type XXVI, alpha 1provided by MGI
Primary source
MGI:MGI:2155345
See related
Ensembl:ENSMUSG00000004415 AllianceGenome:MGI:2155345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emu2; Emid2; Col26a; 9430032K24Rik
Summary
Acts upstream of or within positive regulation of cell-substrate adhesion. Located in Golgi apparatus; endoplasmic reticulum; and extracellular matrix. Is expressed in several structures, including body cavity or lining; cerebellum; genitourinary system; respiratory system; and vertebral axis musculature. Orthologous to human COL26A1 (collagen type XXVI alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 44.2), CNS E11.5 (RPKM 18.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.03 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136770613..136912230, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136741759..136883376, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38722 Neighboring gene myosin, light chain 10, regulatory Neighboring gene STARR-seq mESC enhancer starr_14627 Neighboring gene predicted gene, 30654 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene 20485 Neighboring gene predicted gene 43649 Neighboring gene intraflagellar transport 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of two forms of the Ly-6.2 antigen showing differential expression. Sutton VR, et al. Immunogenetics, 1985. PMID 3874158
  2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. Sato K, et al. J Biol Chem, 2002 Oct 4. PMID 12145293
  3. Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family. Braghetta P, et al. Matrix Biol, 2004 Jan. PMID 14996434
  4. Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement. Singh PNP, et al. Development, 2018 Mar 12. PMID 29467244
  5. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7475

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
collagen alpha-1(XXVI) chain
Names
Collagen XXVI
EMI domain containing 2
EMI domain-containing protein 2
alpha-1 type XXVI collagen
emilin and multimerin domain-containing protein 2
procollagen, type XXVI, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346699.1 → NP_001333628.1  collagen alpha-1(XXVI) chain isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140232, AC147987, AK076445, AK143515
    Consensus CDS
    CCDS84976.1
    UniProtKB/Swiss-Prot
    Q91VF6
    Related
    ENSMUSP00000106732.2, ENSMUST00000111103.2

  2. NM_024474.3 → NP_077794.2  collagen alpha-1(XXVI) chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_077794.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140232, AC147987
    Consensus CDS
    CCDS19755.1
    UniProtKB/Swiss-Prot
    Q8K4P3, Q91VF6
    Related
    ENSMUSP00000052095.7, ENSMUST00000057497.13
    Conserved Domains (1) summary
    pfam07546
    Location:54 → 122
    EMI; EMI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136770613..136912230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504362.1 → XP_006504425.1  collagen alpha-1(XXVI) chain isoform X1

    Conserved Domains (1) summary
    pfam07546
    Location:48 → 81
    EMI; EMI domain

  2. XM_036164781.1 → XP_036020674.1  collagen alpha-1(XXVI) chain isoform X4

  3. XM_006504363.5 → XP_006504426.1  collagen alpha-1(XXVI) chain isoform X4

    See identical proteins and their annotated locations for XP_006504426.1

  4. XM_011240858.3 → XP_011239160.1  collagen alpha-1(XXVI) chain isoform X4

    See identical proteins and their annotated locations for XP_011239160.1

  5. XM_006504364.4 → XP_006504427.1  collagen alpha-1(XXVI) chain isoform X4

    See identical proteins and their annotated locations for XP_006504427.1

  6. XM_006504365.4 → XP_006504428.2  collagen alpha-1(XXVI) chain isoform X2

  7. XM_011240857.4 → XP_011239159.1  collagen alpha-1(XXVI) chain isoform X4

    See identical proteins and their annotated locations for XP_011239159.1

  8. XM_011240856.1 → XP_011239158.1  collagen alpha-1(XXVI) chain isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VF6.1 GenPept UniProtKB/Swiss-Prot:Q91VF6

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