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Ap3m2 adaptor related protein complex 3 subunit mu 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140667, updated on 11-Apr-2024

Summary

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Official Symbol
Ap3m2provided by RGD
Official Full Name
adaptor related protein complex 3 subunit mu 2provided by RGD
Primary source
RGD:70969
See related
Ensembl:ENSRNOG00000018650 AllianceGenome:RGD:70969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in anterograde synaptic vesicle transport and endocytosis. Predicted to be located in several cellular components, including Golgi apparatus; axon cytoplasm; and cytoplasmic vesicle membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 197.4), Spleen (RPKM 50.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap3m2 in Genome Data Viewer
Location:
16q12.5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75908459..75937915)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69217526..69237372)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74075842..74091230)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene lysine acetyltransferase 6A Neighboring gene K(lysine) acetyltransferase 6A like Neighboring gene uncharacterized LOC120097529 Neighboring gene uncharacterized LOC134482521 Neighboring gene plasminogen activator, tissue type Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Nangaku M, et al. Kidney Int, 2001 Aug. PMID 11473647
  2. Two rat homologs of clathrin-associated adaptor proteins. Pevsner J, et al. Gene, 1994 Sep 2. PMID 8076832
  3. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
  4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93230

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde axonal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in anterograde synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde synaptic vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-3 complex subunit mu-2
Names
HA1 47 kDa subunit homolog 2
P47B
adapter-related protein complex 3 mu-2 subunit
adapter-related protein complex 3 subunit mu-2
adaptor-related protein complex 3, mu 2 subunit
clathrin assembly protein assembly protein complex 1 medium chain homolog 2
clathrin assembly protein assembly protein complex 3 mu-2 medium chain
clathrin coat assembly protein AP47 homolog 2
clathrin coat-associated protein AP47 homolog 2
golgi adaptor AP-1 47 kDa protein homolog 2
mu3B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133305.2 → NP_579839.1  AP-3 complex subunit mu-2

    See identical proteins and their annotated locations for NP_579839.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086993
    UniProtKB/Swiss-Prot
    P53678
    UniProtKB/TrEMBL
    A6IW52, V9GZ82
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    75908459..75937915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094175.2 → XP_038950103.1  AP-3 complex subunit mu-2 isoform X1

    UniProtKB/Swiss-Prot
    P53678
    UniProtKB/TrEMBL
    A6IW52, V9GZ82
    Related
    ENSRNOP00000025675.5
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  2. XM_039094177.2 → XP_038950105.1  AP-3 complex subunit mu-2 isoform X1

    UniProtKB/Swiss-Prot
    P53678
    UniProtKB/TrEMBL
    A6IW52, V9GZ82
    Conserved Domains (2) summary
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    cl10970
    Location:165 → 418
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  3. XM_063275047.1 → XP_063131117.1  AP-3 complex subunit mu-2 isoform X1

    UniProtKB/Swiss-Prot
    P53678
    UniProtKB/TrEMBL
    A6IW52
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53678.1 GenPept UniProtKB/Swiss-Prot:P53678

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