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Ubox5 U box domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 140629, updated on 21-Apr-2024

Summary

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Official Symbol
Ubox5provided by MGI
Official Full Name
U box domain containing 5provided by MGI
Primary source
MGI:MGI:2154658
See related
Ensembl:ENSMUSG00000027300 AllianceGenome:MGI:2154658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP5; Rnf37; Ube7ip5; Ubce7ip5; 1500010O06Rik; C330018L13Rik
Summary
Enables ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in nucleus. Is expressed in genitourinary system. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 63.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130431916..130471958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130589996..130630038, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxytocin Neighboring gene arginine vasopressin Neighboring gene FAST kinase domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene leucine zipper, putative tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. Pringa E, et al. J Biol Chem, 2001 Jun 1. PMID 11274149
  2. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818
  3. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
  4. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RING finger protein 37
Names
RING-type E3 ubiquitin transferase RNF37
U-box domain-containing protein 5
UbcM4-interacting protein 5
ubiquitin-conjugating enzyme 7-interacting protein 5
NP_001242922.1
NP_001242923.1
NP_542129.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001255993.1 → NP_001242922.1  RING finger protein 37

    See identical proteins and their annotated locations for NP_001242922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK034114, AK158052, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Conserved Domains (2) summary
    pfam04564
    Location:259 → 337
    U-box; U-box domain
    pfam14634
    Location:484 → 527
    zf-RING_5; zinc-RING finger domain

  2. NM_001255994.1 → NP_001242923.1  RING finger protein 37

    See identical proteins and their annotated locations for NP_001242923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AF360997, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Related
    ENSMUSP00000028761.5, ENSMUST00000028761.5
    Conserved Domains (2) summary
    pfam04564
    Location:259 → 337
    U-box; U-box domain
    pfam14634
    Location:484 → 527
    zf-RING_5; zinc-RING finger domain

  3. NM_080562.5 → NP_542129.2  RING finger protein 37

    See identical proteins and their annotated locations for NP_542129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK034114, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Conserved Domains (2) summary
    pfam04564
    Location:259 → 337
    U-box; U-box domain
    pfam14634
    Location:484 → 527
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130431916..130471958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925F4.2 GenPept UniProtKB/Swiss-Prot:Q925F4

Gene LinkOut

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