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ZFP28 ZFP28 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 140612, updated on 5-Mar-2024

Summary

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Official Symbol
ZFP28provided by HGNC
Official Full Name
ZFP28 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:17801
See related
Ensembl:ENSG00000196867 MIM:616798; AllianceGenome:HGNC:17801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mkr5
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.5), brain (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

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See ZFP28 in Genome Data Viewer
Location:
19q13.43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56536947..56556808)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59631381..59651208)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57050317..57068177)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC124904776 Neighboring gene zinc finger protein 471 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57037017-57038216 Neighboring gene ZFP28 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57058653-57059852 Neighboring gene ZNF470 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57065620-57066819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15122 Neighboring gene zinc finger protein 470 Neighboring gene uncharacterized LOC124904777

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 28 as a novel melanoma-related molecule. Yajima I, et al. J Dermatol Sci, 2009 Jul. PMID 19329283
  2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Zhou L, et al. Biochem Biophys Res Commun, 2002 Jul 26. PMID 12127974
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  5. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results suggest that murine and human Zfp28/ZFP28 is correlated with the pathogenesis of melanoma.
    Title: Zinc finger protein 28 as a novel melanoma-related molecule.
  2. Characterization of ZFP28 and its role in human development
    Title: Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1431, MGC104540, DKFZp686K03205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 28 homolog
Names
krueppel-like zinc finger factor X6
zfp-28
zinc finger factor X6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308440.2 → NP_001295369.1  zinc finger protein 28 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005498, AF507045, BC028416
    Consensus CDS
    CCDS77363.1
    UniProtKB/TrEMBL
    A8K0L8
    Related
    ENSP00000468603.1, ENST00000591844.5
    Conserved Domains (2) summary
    smart00349
    Location:103 → 163
    KRAB; krueppel associated box
    pfam01352
    Location:103 → 142
    KRAB; KRAB box

  2. NM_020828.2 → NP_065879.1  zinc finger protein 28 homolog isoform 1

    See identical proteins and their annotated locations for NP_065879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005498, AF507045
    Consensus CDS
    CCDS12946.1
    UniProtKB/Swiss-Prot
    A0JNV6, K7ES88, Q8NHU8, Q8NHY6, Q9BY30, Q9P2B6
    Related
    ENSP00000301318.3, ENST00000301318.8
    Conserved Domains (6) summary
    smart00349
    Location:103 → 163
    KRAB; krueppel associated box
    COG5048
    Location:417 → 806
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:619 → 639
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:420 → 442
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:103 → 142
    KRAB; KRAB box
    pfam13465
    Location:659 → 684
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56536947..56556808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526463.4 → XP_011524765.2  zinc finger protein 28 homolog isoform X1

  2. XM_011526462.4 → XP_011524764.1  zinc finger protein 28 homolog isoform X2

    See identical proteins and their annotated locations for XP_011524764.1

    Conserved Domains (6) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:320 → 709
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:323 → 345
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:562 → 587
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59631381..59651208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319838.1 → XP_054175813.1  zinc finger protein 28 homolog isoform X1

  2. XM_054319839.1 → XP_054175814.1  zinc finger protein 28 homolog isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHY6.1 GenPept UniProtKB/Swiss-Prot:Q8NHY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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