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Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 14055, updated on 11-Apr-2024

Summary

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Official Symbol
Ezh1provided by MGI
Official Full Name
enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by MGI
Primary source
MGI:MGI:1097695
See related
Ensembl:ENSMUSG00000006920 AllianceGenome:MGI:1097695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENX-2
Summary
This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ezh1 in Genome Data Viewer
Location:
11 D; 11 64.37 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101081941..101117268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101191115..101226463, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101110062-101110171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101114923-101115106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101115117-101115300 Neighboring gene receptor (calcitonin) activity modifying protein 2 Neighboring gene vacuolar protein sorting 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling. Feng X, et al. Dev Cell, 2023 Jun 19. PMID 37105173,
  2. EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Johnstone AL, et al. Neurobiol Dis, 2018 Nov. PMID 30099093
  3. Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mousavi K, et al. Mol Cell, 2012 Jan 27. PMID 22196887
  4. Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis. Arai D, et al. Dev Biol, 2010 May 15. PMID 20227405
  5. Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes. El Said NH, et al. Cell Death Dis, 2021 Sep 16. PMID 34531374, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.
    Title: Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.
  2. Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse.
    Title: Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse.
  3. Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes.
    Title: Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes.
  4. Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons.
    Title: Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons.
  5. The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
    Title: The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
  6. Findings reveal that Ezh1/Ezh2-catalyzed H3K27-trimethyation regulates sex-dependent genetic programs in liver metabolism and liver fibrosis through its sex-dependent effects on the epigenome, and may thereby determine the sex-bias in liver disease susceptibility.
    Title: Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.
  7. Depletion of EZH1 in the prefrontal cortex attenuated sociability, enhanced motivational behaviors and affected gene expression pathways.
    Title: EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.
  8. The Polycomb repressive complex 2 proteins EZH1 and EZH2 regulate genes that control hepatocyte maturation and fibrogenesis and genes not specifically associated with the liver lineage by acting at euchromatic promoter regions. EZH1 and EZH2 thereby promote liver homeostasis and prevent liver damage.
    Title: Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.
  9. The combined loss of Ezh1 and Ezh2 in chondrocytes severely impairs skeletal growth in mice.
    Title: EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.
  10. identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo
    Title: Regulation of embryonic haematopoietic multipotency by EZH1.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K27 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hepatocyte homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within liver regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to tetrachloromethane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH1
Names
enhancer of zeste homolog 1
NP_001390736.1
NP_001390738.1
NP_001390739.1
NP_001390740.1
NP_001390741.1
NP_001390742.1
NP_001390743.1
NP_001390744.1
NP_001390745.1
NP_001390747.1
NP_001390750.1
NP_001390751.1
NP_031996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403807.1 → NP_001390736.1  histone-lysine N-methyltransferase EZH1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL590969

  2. NM_001403809.1 → NP_001390738.1  histone-lysine N-methyltransferase EZH1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL590969
    UniProtKB/Swiss-Prot
    A2A4K5, P70351, Q3TPR1, Q3U3V5, Q3UU02, Q8BR85, Q922L1, Q9R089
    Related
    ENSMUSP00000102905.2, ENSMUST00000107284.8

  3. NM_001403810.1 → NP_001390739.1  histone-lysine N-methyltransferase EZH1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL590969

  4. NM_001403811.1 → NP_001390740.1  histone-lysine N-methyltransferase EZH1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL590969

  5. NM_001403812.1 → NP_001390741.1  histone-lysine N-methyltransferase EZH1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL590969

  6. NM_001403813.1 → NP_001390742.1  histone-lysine N-methyltransferase EZH1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590969

  7. NM_001403814.1 → NP_001390743.1  histone-lysine N-methyltransferase EZH1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL590969

  8. NM_001403815.1 → NP_001390744.1  histone-lysine N-methyltransferase EZH1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL590969
    Related
    ENSMUSP00000097984.3, ENSMUST00000100417.3

  9. NM_001403816.1 → NP_001390745.1  histone-lysine N-methyltransferase EZH1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL590969

  10. NM_001403818.1 → NP_001390747.1  histone-lysine N-methyltransferase EZH1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL590969

  11. NM_001403821.1 → NP_001390750.1  histone-lysine N-methyltransferase EZH1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590969
    UniProtKB/TrEMBL
    A0A0R4J1C0

  12. NM_001403822.1 → NP_001390751.1  histone-lysine N-methyltransferase EZH1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL590969

  13. NM_007970.4 → NP_031996.1  histone-lysine N-methyltransferase EZH1 isoform 1

    See identical proteins and their annotated locations for NP_031996.1

    Status: REVIEWED

    Source sequence(s)
    AL590969
    Consensus CDS
    CCDS36335.1
    UniProtKB/TrEMBL
    A0A0R4J1C0
    Related
    ENSMUSP00000102906.2, ENSMUST00000107285.8
    Conserved Domains (5) summary
    smart00717
    Location:436 → 477
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    smart00317
    Location:616 → 737
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:466 → 730
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:436 → 477
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam11616
    Location:42 → 70
    EZH2_WD-Binding; WD repeat binding protein EZH2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101081941..101117268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70351.1 GenPept UniProtKB/Swiss-Prot:P70351

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