U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eri3 exoribonuclease 3 [ Mus musculus (house mouse) ]

Gene ID: 140546, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Eri3provided by MGI
Official Full Name
exoribonuclease 3provided by MGI
Primary source
MGI:MGI:2153887
See related
Ensembl:ENSMUSG00000033423 AllianceGenome:MGI:2153887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PINT1; Prnpip1
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; major salivary gland; and trigeminal nerve. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 32.0), ovary adult (RPKM 28.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eri3 in Genome Data Viewer
Location:
4 D1; 4 53.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117407416..117531494)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117550241..117674297)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene predicted gene 12827 Neighboring gene predicted gene, 34669 Neighboring gene STARR-positive B cell enhancer mm9_chr4:117222596-117222897 Neighboring gene STARR-seq mESC enhancer starr_11185 Neighboring gene STARR-seq mESC enhancer starr_11187 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117354782-117355011 Neighboring gene DNA methyltransferase 1-associated protein 1 Neighboring gene predicted gene, 34746

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ERI1 exoribonuclease 3
Names
prion interactor 1
prion protein interacting protein 1
prion protein-interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285899.2 → NP_001272828.1  ERI1 exoribonuclease 3 isoform b

    See identical proteins and their annotated locations for NP_001272828.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:105 → 282
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  2. NM_001285901.2 → NP_001272830.1  ERI1 exoribonuclease 3 isoform c

    See identical proteins and their annotated locations for NP_001272830.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  3. NM_001285902.2 → NP_001272831.1  ERI1 exoribonuclease 3 isoform d

    See identical proteins and their annotated locations for NP_001272831.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/Swiss-Prot
    Q8C460
    Conserved Domains (1) summary
    cd06133
    Location:1 → 146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  4. NM_001356404.2 → NP_001343333.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  5. NM_001356405.1 → NP_001343334.1  ERI1 exoribonuclease 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (e) has the same N- and C-termini, but is 2 aa shorter than isoform a.
    Source sequence(s)
    AK083017, BE944838, BY255598
    Conserved Domains (1) summary
    cd06133
    Location:144 → 321
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  6. NM_001379279.1 → NP_001366208.1  ERI1 exoribonuclease 3 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:146 → 345
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  7. NM_001379280.1 → NP_001366209.1  ERI1 exoribonuclease 3 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:107 → 284
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  8. NM_001379281.1 → NP_001366210.1  ERI1 exoribonuclease 3 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  9. NM_001379282.1 → NP_001366211.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  10. NM_001379283.1 → NP_001366212.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  11. NM_001379284.1 → NP_001366213.1  ERI1 exoribonuclease 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:1 → 146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  12. NM_001379285.1 → NP_001366214.1  ERI1 exoribonuclease 3 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:35 → 205
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  13. NM_080469.5 → NP_536717.2  ERI1 exoribonuclease 3 isoform a

    See identical proteins and their annotated locations for NP_536717.2

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Consensus CDS
    CCDS18535.1
    UniProtKB/Swiss-Prot
    A2ADW0, A2ADW2, Q149R0, Q68FL7, Q8C460, Q923K5
    Related
    ENSMUSP00000042796.9, ENSMUST00000037127.15
    Conserved Domains (1) summary
    cd06133
    Location:146 → 323
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117407416..117531494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319962.3 → XP_017175451.2  ERI1 exoribonuclease 3 isoform X5

    Conserved Domains (1) summary
    cd06133
    Location:121 → 285
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  2. XM_030253198.2 → XP_030109058.2  ERI1 exoribonuclease 3 isoform X8

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:121 → 298
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  3. XM_036163665.1 → XP_036019558.1  ERI1 exoribonuclease 3 isoform X10

    Conserved Domains (1) summary
    cd06133
    Location:121 → 256
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  4. XM_030253202.1 → XP_030109062.1  ERI1 exoribonuclease 3 isoform X12

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  5. XM_017319971.2 → XP_017175460.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1 → 133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  6. XM_036163669.1 → XP_036019562.1  ERI1 exoribonuclease 3 isoform X14

    Conserved Domains (1) summary
    cd06133
    Location:1 → 168
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  7. XM_017319970.3 → XP_017175459.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1 → 133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  8. XM_017319961.3 → XP_017175450.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68 → 232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  9. XM_030253200.1 → XP_030109060.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68 → 203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  10. XM_017319964.3 → XP_017175453.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68 → 232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  11. XM_036163663.1 → XP_036019556.1  ERI1 exoribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  12. XM_017319972.3 → XP_017175461.1  ERI1 exoribonuclease 3 isoform X16

    Conserved Domains (1) summary
    cd06133
    Location:1 → 114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  13. XM_017319965.3 → XP_017175454.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68 → 232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  14. XM_036163670.1 → XP_036019563.1  ERI1 exoribonuclease 3 isoform X15

    Conserved Domains (1) summary
    cd06133
    Location:1 → 146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  15. XM_011240437.4 → XP_011238739.2  ERI1 exoribonuclease 3 isoform X1

    Conserved Domains (1) summary
    cd06133
    Location:146 → 310
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  16. XM_030253195.2 → XP_030109055.1  ERI1 exoribonuclease 3 isoform X3

    Conserved Domains (1) summary
    cd06133
    Location:146 → 281
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  17. XM_017319960.3 → XP_017175449.1  ERI1 exoribonuclease 3 isoform X2

    Conserved Domains (1) summary
    cd06133
    Location:144 → 308
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  18. XM_036163661.1 → XP_036019554.1  ERI1 exoribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68 → 267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  19. XM_036163664.1 → XP_036019557.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68 → 203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  20. XM_036163671.1 → XP_036019564.1  ERI1 exoribonuclease 3 isoform X16

    Related
    ENSMUST00000146384.8
    Conserved Domains (1) summary
    cd06133
    Location:1 → 114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  21. XM_036163667.1 → XP_036019560.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1 → 133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  22. XM_036163668.1 → XP_036019561.1  ERI1 exoribonuclease 3 isoform X14

    Conserved Domains (1) summary
    cd06133
    Location:1 → 168
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  23. XM_030253209.1 → XP_030109069.1  ERI1 exoribonuclease 3 isoform X16

    Conserved Domains (1) summary
    cd06133
    Location:1 → 114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  24. XM_036163666.1 → XP_036019559.1  ERI1 exoribonuclease 3 isoform X11

    Conserved Domains (1) summary
    cd06133
    Location:35 → 192
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  25. XM_017319966.3 → XP_017175455.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68 → 232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  26. XM_030253208.1 → XP_030109068.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68 → 203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  27. XM_036163662.1 → XP_036019555.1  ERI1 exoribonuclease 3 isoform X7

    Conserved Domains (1) summary
    cd06133
    Location:105 → 269
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

  28. XM_017319967.2 → XP_017175456.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68 → 232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RNA

  1. XR_003954874.2 RNA Sequence

  2. XR_004941810.1 RNA Sequence

  3. XR_003954875.2 RNA Sequence

  4. XR_003954876.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C460.1 GenPept UniProtKB/Swiss-Prot:Q8C460

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous