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Eya4 EYA transcriptional coactivator and phosphatase 4 [ Mus musculus (house mouse) ]

Gene ID: 14051, updated on 11-Apr-2024

Summary

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Official Symbol
Eya4provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 4provided by MGI
Primary source
MGI:MGI:1337104
See related
Ensembl:ENSMUSG00000010461 AllianceGenome:MGI:1337104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130023L16Rik
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within middle ear morphogenesis and sensory perception of sound. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; limb bud; sensory organ; and urinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 3.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Eya4 in Genome Data Viewer
Location:
10 A3; 10 10.44 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22978861..23226785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23102962..23350838, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26037 Neighboring gene predicted gene, 35126 Neighboring gene predicted gene, 35179 Neighboring gene STARR-seq mESC enhancer starr_26038 Neighboring gene STARR-seq mESC enhancer starr_26039 Neighboring gene STARR-seq mESC enhancer starr_26040 Neighboring gene predicted gene, 24655 Neighboring gene STARR-seq mESC enhancer starr_26042 Neighboring gene predicted gene, 53620 Neighboring gene STARR-seq mESC enhancer starr_26043 Neighboring gene predicted gene, 47843 Neighboring gene STARR-seq mESC enhancer starr_26044 Neighboring gene STARR-seq mESC enhancer starr_26045 Neighboring gene STARR-seq mESC enhancer starr_26046 Neighboring gene predicted gene, 35291

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of the innate immune response by threonine-phosphatase of Eyes absent. Okabe Y, et al. Nature, 2009 Jul 23. PMID 19561593
  2. EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. Abe Y, et al. Hum Mutat, 2009 Oct. PMID 19606496
  3. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Komada M, et al. Genes Dev, 2000 Jun 1. PMID 10837026, Free PMC Article
  4. A six-gene expression toolbox for the glands, epithelium and chondrocytes in the mouse nasal cavity. Wan Y, et al. Gene Expr Patterns, 2018 Jan. PMID 29122676
  5. Eya4 Induces Hypertrophy via Regulation of p27kip1. Williams T, et al. Circ Cardiovasc Genet, 2015 Dec. PMID 26499333

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results implicate Eya4/Six1 regulates normal cardiac function via p27/casein kinase-2alpha/histone deacetylase 2 and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy.
    Title: Eya4 Induces Hypertrophy via Regulation of p27kip1.
  2. that Eyes absent 4 (EYA4), originally identified as a co-transcription factor, stimulates the expression of IFN-beta and CXCL10 in response to the undigested DNA of apoptotic cells
    Title: Regulation of the innate immune response by threonine-phosphatase of Eyes absent.
  3. Eya4(-/-) mice developed otitis media with effusion; anatomic studies revealed abnormal middle ear cavity and eustachian tube dysmorphology.
    Title: Eya4-deficient mice are a model for heritable otitis media.
  4. constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 prey constructs, although no interaction with Dach1 prey was demonstrable
    Title: A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eyes absent homolog 4
Names
eyes absent 4 homolog
NP_001334301.1
NP_034297.2
XP_006512592.1
XP_017169288.1
XP_030100738.1
XP_030100739.1
XP_030100740.1
XP_036011486.1
XP_036011487.1
XP_036011488.1
XP_036011489.1
XP_036011490.1
XP_036011491.1
XP_036011492.1
XP_036011493.1
XP_036011494.1
XP_036011495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347372.2 → NP_001334301.1  eyes absent homolog 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113497, AC153551, AC153914
    Consensus CDS
    CCDS83687.1
    UniProtKB/Swiss-Prot
    Q0VAV8, Q9Z191
    Related
    ENSMUSP00000151287.2, ENSMUST00000220299.2
    Conserved Domains (2) summary
    PTZ00395
    Location:139 → 318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345 → 616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  2. NM_001428461.1 → NP_001415390.1  eyes absent homolog 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113497, AC153551, AC153914
    UniProtKB/TrEMBL
    A0A1W2P721

  3. NM_001428462.1 → NP_001415391.1  eyes absent homolog 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113497, AC153551, AC153914

  4. NM_010167.6 → NP_034297.2  eyes absent homolog 4 isoform 1

    See identical proteins and their annotated locations for NP_034297.2

    Status: VALIDATED

    Source sequence(s)
    AC113497, AC153551, AC153914
    Consensus CDS
    CCDS35867.1
    UniProtKB/TrEMBL
    Q8BY78
    Related
    ENSMUSP00000090335.5, ENSMUST00000092665.12
    Conserved Domains (2) summary
    PTZ00395
    Location:139 → 318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345 → 616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

RNA

  1. NR_190356.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113497, AC153551, AC153914

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    22978861..23226785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155597.1 → XP_036011490.1  eyes absent homolog 4 isoform X2

    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  2. XM_036155601.1 → XP_036011494.1  eyes absent homolog 4 isoform X5

    UniProtKB/TrEMBL
    Q8BY78
    Conserved Domains (2) summary
    PTZ00395
    Location:139 → 318
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:345 → 616
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  3. XM_036155598.1 → XP_036011491.1  eyes absent homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P721
    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  4. XM_036155596.1 → XP_036011489.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  5. XM_036155594.1 → XP_036011487.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  6. XM_036155602.1 → XP_036011495.1  eyes absent homolog 4 isoform X9

    Conserved Domains (2) summary
    PTZ00395
    Location:3 → 182
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:209 → 480
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  7. XM_017313799.2 → XP_017169288.1  eyes absent homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P721
    Related
    ENSMUSP00000151483.2, ENSMUST00000219315.2
    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  8. XM_036155595.1 → XP_036011488.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  9. XM_036155593.1 → XP_036011486.1  eyes absent homolog 4 isoform X1

    Conserved Domains (2) summary
    PTZ00395
    Location:162 → 341
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:368 → 639
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  10. XM_030244880.2 → XP_030100740.1  eyes absent homolog 4 isoform X10

    Conserved Domains (2) summary
    PTZ00395
    Location:108 → 287
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:314 → 585
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  11. XM_006512529.5 → XP_006512592.1  eyes absent homolog 4 isoform X6

    Conserved Domains (2) summary
    PTZ00395
    Location:108 → 287
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:314 → 585
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  12. XM_030244878.2 → XP_030100738.1  eyes absent homolog 4 isoform X7

    Conserved Domains (2) summary
    PTZ00395
    Location:100 → 279
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:306 → 577
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  13. XM_030244879.2 → XP_030100739.1  eyes absent homolog 4 isoform X8

    Conserved Domains (2) summary
    PTZ00395
    Location:79 → 258
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:285 → 556
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  14. XM_036155599.1 → XP_036011492.1  eyes absent homolog 4 isoform X3

    Conserved Domains (2) summary
    PTZ00395
    Location:154 → 333
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:360 → 631
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  15. XM_036155600.1 → XP_036011493.1  eyes absent homolog 4 isoform X4

    Conserved Domains (2) summary
    PTZ00395
    Location:149 → 328
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:355 → 626
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

RNA

  1. XR_004936098.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z191.2 GenPept UniProtKB/Swiss-Prot:Q9Z191

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