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Eya3 EYA transcriptional coactivator and phosphatase 3 [ Mus musculus (house mouse) ]

Gene ID: 14050, updated on 5-Mar-2024

Summary

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Official Symbol
Eya3provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 3provided by MGI
Primary source
MGI:MGI:109339
See related
Ensembl:ENSMUSG00000028886 AllianceGenome:MGI:109339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; rhombomere; and sensory organ. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.7), limb E14.5 (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 65.68 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132366303..132452076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132639025..132724765)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene predicted gene, 54261 Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene platelet-activating factor receptor Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene X-linked Kx blood group related 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Wang Y, et al. Nat Commun, 2019 Sep 12. PMID 31515519, Free PMC Article
  2. Characterization of the threonine-phosphatase of mouse eyes absent 3. Sano T, et al. FEBS Lett, 2011 Sep 2. PMID 21821028
  3. Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism. Masumoto KH, et al. Curr Biol, 2010 Dec 21. PMID 21129973
  4. The transcription factor Eyes absent is a protein tyrosine phosphatase. Tootle TL, et al. Nature, 2003 Nov 20. PMID 14628053
  5. Misexpression of the eyes absent family triggers the apoptotic program. Clark SW, et al. J Biol Chem, 2002 Feb 1. PMID 11700312

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these observations establish EYA3 as a disease-modifying target whose function in the pathophysiology of pulmonary arterial hypertension.
    Title: The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
  2. Data showed that the 68-amino acid domain between positions 53 and 120 was necessary and sufficient for its threonine-phosphatase activity.
    Title: Characterization of the threonine-phosphatase of mouse eyes absent 3.
  3. Data demonstrate that Eya3 and its partner Six1 synergistically activate TSHbeta expression and that this activation is further enhanced by Tef and Hlf.
    Title: Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism.
  4. Ski is necessary for muscle terminal differentiation and that it exerts this role, at least in part, through its association with Six1 and Eya3 to regulate the Myog transcription
    Title: Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.
  5. There was no obvious defect in the eyes, ears and kidneys of Eya3 mutant mice. Homozygous mutants displayed decreased bone mineral content and shorter body length.
    Title: Pleiotropic effects in Eya3 knockout mice.
  6. Experiments performed in cultured Drosophila cells and in vitro indicate that Eyes absent has intrinsic protein tyrosine phosphatase activity and can autocatalytically dephosphorylate itself
    Title: The transcription factor Eyes absent is a protein tyrosine phosphatase.
  7. The phosphatase function of Eya switches the function of Six1-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators
    Title: Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables histone H2AXY142 phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
eyes absent homolog 3
Names
eyes absent 3 homolog
NP_001390684.1
NP_001390685.1
NP_001390686.1
NP_001390687.1
NP_001390688.1
NP_001390689.1
NP_034296.2
NP_997592.1
NP_997596.1
XP_006538603.1
XP_036019552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403755.1 → NP_001390684.1  eyes absent homolog 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627130

  2. NM_001403756.1 → NP_001390685.1  eyes absent homolog 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627130

  3. NM_001403757.1 → NP_001390686.1  eyes absent homolog 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627130

  4. NM_001403758.1 → NP_001390687.1  eyes absent homolog 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627130

  5. NM_001403759.1 → NP_001390688.1  eyes absent homolog 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627130

  6. NM_001403760.1 → NP_001390689.1  eyes absent homolog 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL627130

  7. NM_010166.4 → NP_034296.2  eyes absent homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_034296.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18730.1
    UniProtKB/Swiss-Prot
    G5E8I5, P97480, P97768
    Related
    ENSMUSP00000078157.5, ENSMUST00000079157.11
    Conserved Domains (1) summary
    TIGR01658
    Location:239 → 510
    EYA-cons_domain; eyes absent protein conserved domain

  8. NM_210071.3 → NP_997592.1  eyes absent homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_997592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18729.1
    UniProtKB/TrEMBL
    Q6P4T3
    Related
    ENSMUSP00000080425.7, ENSMUST00000081726.13
    Conserved Domains (1) summary
    TIGR01658
    Location:255 → 526
    EYA-cons_domain; eyes absent protein conserved domain

  9. NM_211357.3 → NP_997596.1  eyes absent homolog 3 isoform 3

    See identical proteins and their annotated locations for NP_997596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18731.1
    UniProtKB/TrEMBL
    Q6P4T3
    Related
    ENSMUSP00000020197.8, ENSMUST00000020197.14
    Conserved Domains (1) summary
    TIGR01658
    Location:145 → 416
    EYA-cons_domain; eyes absent protein conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132366303..132452076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538540.5 → XP_006538603.1  eyes absent homolog 3 isoform X5

    UniProtKB/TrEMBL
    A2A953
    Related
    ENSMUSP00000123045.2, ENSMUST00000135299.8
    Conserved Domains (1) summary
    TIGR01658
    Location:301 → 360
    EYA-cons_domain; eyes absent protein conserved domain

  2. XM_036163659.1 → XP_036019552.1  eyes absent homolog 3 isoform X3

    Conserved Domains (1) summary
    TIGR01658
    Location:253 → 524
    EYA-cons_domain; eyes absent protein conserved domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_211356.1: Suppressed sequence

    Description
    NM_211356.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97480.2 GenPept UniProtKB/Swiss-Prot:P97480

Gene LinkOut

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