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Ube2j2 ubiquitin-conjugating enzyme E2J 2 [ Mus musculus (house mouse) ]

Gene ID: 140499, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2j2provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2J 2provided by MGI
Primary source
MGI:MGI:2153608
See related
Ensembl:ENSMUSG00000023286 AllianceGenome:MGI:2153608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubc6; Ubc6p; NCUBE-2; 1200007B18Rik; 2400008G19Rik; 5730472G04Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Located in endoplasmic reticulum. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 19.1), colon adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2j2 in Genome Data Viewer
Location:
4 E2; 4 87.66 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156028270..156044061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155943813..155959604)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. Wang X, et al. J Cell Biol, 2009 Nov 30. PMID 19951915, Free PMC Article
  2. A role for mammalian Ubc6 homologues in ER-associated protein degradation. Lenk U, et al. J Cell Sci, 2002 Jul 15. PMID 12082160
  3. TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. Wu CJ, et al. EMBO J, 2005 May 18. PMID 15861135, Free PMC Article
  4. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
  5. A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate. Polge C, et al. J Cachexia Sarcopenia Muscle, 2018 Feb. PMID 29271608, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 J2
Names
Ubc6p homolog
non-canonical ubiquitin-conjugating enzyme 2
ubiquitin conjugating enzyme 6
ubiquitin-conjugating enzyme E2, J2 homolog
NP_001034246.1
NP_001034247.1
NP_001034248.1
NP_001271241.1
NP_001271243.1
NP_067377.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039157.2 → NP_001034246.1  ubiquitin-conjugating enzyme E2 J2 isoform a

    See identical proteins and their annotated locations for NP_001034246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a).
    Source sequence(s)
    AK004626, AK010302, AL627204, BC065779
    Consensus CDS
    CCDS19050.1
    UniProtKB/TrEMBL
    B1ASK8
    Related
    ENSMUSP00000101208.3, ENSMUST00000105583.9
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001039158.2 → NP_001034247.1  ubiquitin-conjugating enzyme E2 J2 isoform b

    See identical proteins and their annotated locations for NP_001034247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform b, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK004626, AL627204, BC065779
    Consensus CDS
    CCDS19051.1
    UniProtKB/Swiss-Prot
    Q6P073, Q8C6A1, Q91Y64, Q9CWY5, Q9DC18, Q9QX58
    Related
    ENSMUSP00000127712.2, ENSMUST00000166489.8
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_001039159.2 → NP_001034248.1  ubiquitin-conjugating enzyme E2 J2 isoform b

    See identical proteins and their annotated locations for NP_001034248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform b, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK004626, AL627204, BC065779
    Consensus CDS
    CCDS19051.1
    UniProtKB/Swiss-Prot
    Q6P073, Q8C6A1, Q91Y64, Q9CWY5, Q9DC18, Q9QX58
    Related
    ENSMUSP00000099464.2, ENSMUST00000103175.8
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_001284312.1 → NP_001271241.1  ubiquitin-conjugating enzyme E2 J2 isoform a

    See identical proteins and their annotated locations for NP_001271241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a).
    Source sequence(s)
    AL627204, BC065779
    Consensus CDS
    CCDS19050.1
    UniProtKB/TrEMBL
    B1ASK8
    Related
    ENSMUSP00000101207.2, ENSMUST00000105582.8
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  5. NM_001284314.1 → NP_001271243.1  ubiquitin-conjugating enzyme E2 J2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 5' and 3' coding regions and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AK004626, AL627204, AW826087, BC065779
    Consensus CDS
    CCDS71536.1
    UniProtKB/TrEMBL
    B0QZM1
    Related
    ENSMUSP00000112785.2, ENSMUST00000118192.8
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  6. NM_021402.6 → NP_067377.4  ubiquitin-conjugating enzyme E2 J2 isoform a

    See identical proteins and their annotated locations for NP_067377.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 5 encode the same isoform (a).
    Source sequence(s)
    AK004626, AK010302, AL627204, BC065779
    Consensus CDS
    CCDS19050.1
    UniProtKB/TrEMBL
    B1ASK8
    Related
    ENSMUSP00000024056.4, ENSMUST00000024056.10
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156028270..156044061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P073.1 GenPept UniProtKB/Swiss-Prot:Q6P073

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