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ZNF358 zinc finger protein 358 [ Homo sapiens (human) ]

Gene ID: 140467, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF358provided by HGNC
Official Full Name
zinc finger protein 358provided by HGNC
Primary source
HGNC:HGNC:16838
See related
Ensembl:ENSG00000198816 MIM:619496; AllianceGenome:HGNC:16838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFEND
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and stem cell population maintenance. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 21.7), ovary (RPKM 18.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7513880..7521025)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7514603..7521761)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7580989..7585911)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7541732-7542367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7548591-7549112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9983 Neighboring gene Sharpr-MPRA regulatory region 6634 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9984 Neighboring gene Sharpr-MPRA regulatory region 11228 Neighboring gene uncharacterized LOC105372261 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9985 Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13887 Neighboring gene mucolipin TRP cation channel 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7614843-7615534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7615535-7616226 Neighboring gene patatin like phospholipase domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization and in silico mapping of a novel murine zinc finger transcription factor. Wride MA, et al. Gene, 2002 May 1. PMID 12036583
  2. Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. Bassi MT, et al. Am J Hum Genet, 2000 Nov. PMID 11013137, Free PMC Article
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  4. EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation. Wang L, et al. Nat Commun, 2022 Jan 10. PMID 35013218, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10390

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 358

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018083.5 → NP_060553.4  zinc finger protein 358

    See identical proteins and their annotated locations for NP_060553.4

    Status: VALIDATED

    Source sequence(s)
    AC008878, AK001252, BC003585, BI601846
    Consensus CDS
    CCDS32890.2
    UniProtKB/Swiss-Prot
    Q9BTM7, Q9NW07
    Related
    ENSP00000472305.1, ENST00000597229.2
    Conserved Domains (6) summary
    cd11674
    Location:108 → 174
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:35 → 339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:166 → 190
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:292 → 370
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7513880..7521025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438181.1 → XP_047294137.1  zinc finger protein 358 isoform X1

  2. XM_005272460.4 → XP_005272517.1  zinc finger protein 358 isoform X2

    See identical proteins and their annotated locations for XP_005272517.1

    UniProtKB/Swiss-Prot
    Q9BTM7, Q9NW07
    Conserved Domains (6) summary
    cd11674
    Location:108 → 174
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:35 → 339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:166 → 190
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:292 → 370
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_011527695.1 → XP_011525997.1  zinc finger protein 358 isoform X2

    See identical proteins and their annotated locations for XP_011525997.1

    UniProtKB/Swiss-Prot
    Q9BTM7, Q9NW07
    Conserved Domains (6) summary
    cd11674
    Location:108 → 174
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:35 → 339
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:166 → 190
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:292 → 370
    zf-C2H2_8; C2H2-type zinc ribbon

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7514603..7521761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319835.1 → XP_054175810.1  zinc finger protein 358 isoform X1

  2. XM_054319836.1 → XP_054175811.1  zinc finger protein 358 isoform X2

    UniProtKB/Swiss-Prot
    Q9BTM7, Q9NW07

  3. XM_054319837.1 → XP_054175812.1  zinc finger protein 358 isoform X2

    UniProtKB/Swiss-Prot
    Q9BTM7, Q9NW07
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NW07.2 GenPept UniProtKB/Swiss-Prot:Q9NW07

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