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ASB11 ankyrin repeat and SOCS box containing 11 [ Homo sapiens (human) ]

Gene ID: 140456, updated on 5-Mar-2024

Summary

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Official Symbol
ASB11provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 11provided by HGNC
Primary source
HGNC:HGNC:17186
See related
Ensembl:ENSG00000165192 MIM:300626; AllianceGenome:HGNC:17186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
Xp22.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (15281697..15315640, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (14864580..14898525, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15299819..15333762, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 37 Neighboring gene ankyrin repeat and SOCS box containing 9 Neighboring gene Sharpr-MPRA regulatory region 14330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29447 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene PIR-FIGF readthrough Neighboring gene vascular endothelial growth factor D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The novel gene asb11: a regulator of the size of the neural progenitor compartment. Diks SH, et al. J Cell Biol, 2006 Aug 14. PMID 16893969, Free PMC Article
  2. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. Chen FY, et al. J Cell Biol, 2019 Sep 2. PMID 31387940, Free PMC Article
  3. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
  4. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study reveals that different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive, and that blocking BIK degradation has the potential to be used as an anti-cancer strategy.
    Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
  2. ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of Ribophorin 1, an integral protein of the oligosaccharyltransferase (OST) glycosylation complex.
    Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119168, MGC119169, DKFZp779E2460

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 11
Names
ASB-11
ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ankyrin repeat domain-containing SOCS box protein ASB11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012627.1 RefSeqGene

    Range
    4966..38909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012428.2 → NP_001012428.1  ankyrin repeat and SOCS box protein 11 isoform b

    See identical proteins and their annotated locations for NP_001012428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC095351, AF425642, BX537853, BX537857
    Consensus CDS
    CCDS35209.1
    UniProtKB/TrEMBL
    Q7Z670
    Related
    ENSP00000343408.4, ENST00000344384.8
    Conserved Domains (5) summary
    cd00204
    Location:45 → 162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:261 → 302
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:146 → 237
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:45 → 97
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:45 → 74
    ANK; ANK repeat [structural motif]

  2. NM_001201583.2 → NP_001188512.1  ankyrin repeat and SOCS box protein 11 isoform c

    See identical proteins and their annotated locations for NP_001188512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform 1.
    Source sequence(s)
    AC095351, BX537857
    Consensus CDS
    CCDS56596.1
    UniProtKB/Swiss-Prot
    Q8WXH4
    Related
    ENSP00000369837.3, ENST00000380470.7
    Conserved Domains (4) summary
    cd00204
    Location:108 → 230
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:265 → 306
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:150 → 241
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:148 → 176
    ANK; ANK repeat [structural motif]

  3. NM_080873.3 → NP_543149.1  ankyrin repeat and SOCS box protein 11 isoform a

    See identical proteins and their annotated locations for NP_543149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC095351, AF425642, BX537857
    Consensus CDS
    CCDS14164.1
    UniProtKB/Swiss-Prot
    E9PEN1, Q3SYC4, Q7Z667, Q8WXH4
    UniProtKB/TrEMBL
    Q7Z670
    Related
    ENSP00000417914.1, ENST00000480796.6
    Conserved Domains (5) summary
    cd00204
    Location:66 → 183
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:282 → 323
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:167 → 258
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66 → 118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    15281697..15315640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    14864580..14898525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXH4.1 GenPept UniProtKB/Swiss-Prot:Q8WXH4

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