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Evi5 ecotropic viral integration site 5 [ Mus musculus (house mouse) ]

Gene ID: 14020, updated on 5-Mar-2024

Summary

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Official Symbol
Evi5provided by MGI
Official Full Name
ecotropic viral integration site 5provided by MGI
Primary source
MGI:MGI:104736
See related
Ensembl:ENSMUSG00000011831 AllianceGenome:MGI:104736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NB4S
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cell division. Predicted to be located in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; paravertebral ganglion; and spleen. Orthologous to human EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 3.7), placenta adult (RPKM 3.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 52.23 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107892661..108022973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107744795..107875107, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Gfi1 +5.8 kb enhancer Neighboring gene Gfi1 promoter regions Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene growth factor independent 1 transcription repressor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:108168116-108168348 Neighboring gene predicted gene, 42147 Neighboring gene Gfi1 -35 kb enhancer Neighboring gene STARR-seq mESC enhancer starr_13892 Neighboring gene STARR-seq mESC enhancer starr_13893 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene STARR-positive B cell enhancer ABC_E9017 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene predicted gene, 22270 Neighboring gene ribosomal protein L5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. Baron BW, et al. Blood Cells Mol Dis, 2014 Jan. PMID 23910958, Free PMC Article
  2. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Jacob B, et al. Blood, 2010 Feb 25. PMID 20008790, Free PMC Article
  3. Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5. Liao X, et al. J Virol, 1995 Nov. PMID 7474133, Free PMC Article
  4. A new region of synteny between human chromosome 1p22 and mouse chromosome 5. Chelsea DM, et al. Int J Mol Med, 2000 May. PMID 10762661
  5. MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene. Schmidt T, et al. Nucleic Acids Res, 1996 Jul 1. PMID 8692692, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GFI1B, EVI5, MYB are additional mouse genes that cooperate with the human BCL6 gene to promote the development of lymphomas.
    Title: GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas.
  2. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
    Title: Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecotropic viral integration site 5 protein
Names
EVI-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378824.1 → NP_001365753.1  ecotropic viral integration site 5 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138666
    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:348 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001378825.1 → NP_001365754.1  ecotropic viral integration site 5 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138666
    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:361 → 670
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_007964.2 → NP_031990.2  ecotropic viral integration site 5 protein isoform 1

    See identical proteins and their annotated locations for NP_031990.2

    Status: VALIDATED

    Source sequence(s)
    AC117574, AC138666, AK134294, BI737814, CN456828, CV557033
    Consensus CDS
    CCDS39198.1
    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    UniProtKB/TrEMBL
    F8VPT6
    Related
    ENSMUSP00000108261.2, ENSMUST00000112642.8
    Conserved Domains (3) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam06386
    Location:527 → 674
    GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
    cl11555
    Location:456 → 494
    DUF1129; Protein of unknown function (DUF1129)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107892661..108022973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534781.3 → XP_006534844.1  ecotropic viral integration site 5 protein isoform X5

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:406 → 709
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006534776.4 → XP_006534839.1  ecotropic viral integration site 5 protein isoform X1

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:392 → 737
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006534783.5 → XP_006534846.1  ecotropic viral integration site 5 protein isoform X6

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:392 → 737
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_006534780.5 → XP_006534843.1  ecotropic viral integration site 5 protein isoform X4

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:389 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_006534779.4 → XP_006534842.1  ecotropic viral integration site 5 protein isoform X3

    See identical proteins and their annotated locations for XP_006534842.1

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:348 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_011249407.4 → XP_011247709.1  ecotropic viral integration site 5 protein isoform X3

    See identical proteins and their annotated locations for XP_011247709.1

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:348 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006534777.5 → XP_006534840.1  ecotropic viral integration site 5 protein isoform X2

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:144 → 352
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:376 → 721
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_030254127.2 → XP_030109987.1  ecotropic viral integration site 5 protein isoform X9

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:362 → 658
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_006534784.4 → XP_006534847.1  ecotropic viral integration site 5 protein isoform X7

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:71 → 279
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:303 → 648
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_006534785.5 → XP_006534848.1  ecotropic viral integration site 5 protein isoform X8

    UniProtKB/Swiss-Prot
    P97366, Q3TPQ1
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:392 → 737
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_006534786.2 → XP_006534849.1  ecotropic viral integration site 5 protein isoform X10

    UniProtKB/TrEMBL
    E9PWR7
    Related
    ENSMUSP00000114845.2, ENSMUST00000128723.8
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:389 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_011249408.4 → XP_011247710.1  ecotropic viral integration site 5 protein isoform X11

    UniProtKB/TrEMBL
    E9PWR7
    Conserved Domains (2) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:389 → 731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_006534787.4 → XP_006534850.1  ecotropic viral integration site 5 protein isoform X12

    Related
    ENSMUSP00000119196.2, ENSMUST00000138111.8
    Conserved Domains (1) summary
    smart00164
    Location:160 → 368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  14. XM_036164779.1 → XP_036020672.1  ecotropic viral integration site 5 protein isoform X13

    UniProtKB/TrEMBL
    Q3TMK4
    Related
    ENSMUSP00000121761.2, ENSMUST00000124034.8
    Conserved Domains (1) summary
    smart00164
    Location:116 → 324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97366.2 GenPept UniProtKB/Swiss-Prot:P97366

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