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Evi2a ecotropic viral integration site 2a [ Mus musculus (house mouse) ]

Gene ID: 14017, updated on 5-Mar-2024

Summary

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Official Symbol
Evi2aprovided by MGI
Official Full Name
ecotropic viral integration site 2aprovided by MGI
Primary source
MGI:MGI:95458
See related
Ensembl:ENSMUSG00000078771 AllianceGenome:MGI:95458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Evi2; Evi-2
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in thymus primordium and ureter. Orthologous to human EVI2A (ecotropic viral integration site 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.5), spleen adult (RPKM 8.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79417386..79421435, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79526560..79530609, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2b Neighboring gene ecotropic viral integration site 2 Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II) Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79428461-79428644 Neighboring gene predicted gene, 23293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. Largaespada DA, et al. J Virol, 1995 Aug. PMID 7609078, Free PMC Article
  2. Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas. Cho BC, et al. J Virol, 1995 Nov. PMID 7474134, Free PMC Article
  3. Evi-2, a common integration site involved in murine myeloid leukemogenesis. Buchberg AM, et al. Mol Cell Biol, 1990 Sep. PMID 2167436, Free PMC Article
  4. Function of 14-3-3 proteins. Jin DY, et al. Nature, 1996 Jul 25. PMID 8684458
  5. The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1. Kurtz A, et al. Mamm Genome, 1995 Feb. PMID 7767001

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Evi2

Readthrough gene: Evi2, Included gene: Evi2b

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein EVI2A
Names
EVI-2A
ecotropic viral integration site 2A protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033711.1 → NP_001028883.1  protein EVI2A precursor

    See identical proteins and their annotated locations for NP_001028883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591174, BC038124
    Consensus CDS
    CCDS25122.1
    UniProtKB/Swiss-Prot
    P20934, Q6DKP1
    UniProtKB/TrEMBL
    Q3TBB7
    Related
    ENSMUSP00000159581.1, ENSMUST00000133148.3
    Conserved Domains (1) summary
    pfam05399
    Location:1 → 223
    EVI2A; Ectropic viral integration site 2A protein (EVI2A)

  2. NM_010161.3 → NP_034291.1  protein EVI2A precursor

    See identical proteins and their annotated locations for NP_034291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591174, BC038124
    Consensus CDS
    CCDS25122.1
    UniProtKB/Swiss-Prot
    P20934, Q6DKP1
    UniProtKB/TrEMBL
    Q3TBB7
    Related
    ENSMUSP00000099526.4, ENSMUST00000103236.4
    Conserved Domains (1) summary
    pfam05399
    Location:1 → 223
    EVI2A; Ectropic viral integration site 2A protein (EVI2A)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79417386..79421435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20934.2 GenPept UniProtKB/Swiss-Prot:P20934

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