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Mecom MDS1 and EVI1 complex locus [ Mus musculus (house mouse) ]

Gene ID: 14013, updated on 23-Apr-2024

Summary

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Official Symbol
Mecomprovided by MGI
Official Full Name
MDS1 and EVI1 complex locusprovided by MGI
Primary source
MGI:MGI:95457
See related
Ensembl:ENSMUSG00000027684 AllianceGenome:MGI:95457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jbo; Mds; Evi1; Mds1; Evi-1; Prdm3; Znfpr1b1; Mds1-Evi1; D630039M04Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone methyltransferase activity (H3-K9 specific). Involved in hematopoietic stem cell proliferation; heterochromatin organization; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 7.5), limb E14.5 (RPKM 5.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 12.66 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30005445..30563937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (29951296..30509759, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_07281 Neighboring gene predicted gene, 42197 Neighboring gene STARR-seq mESC enhancer starr_07282 Neighboring gene STARR-seq mESC enhancer starr_07283 Neighboring gene predicted gene, 33206 Neighboring gene STARR-seq mESC enhancer starr_07284 Neighboring gene STARR-seq mESC enhancer starr_07285 Neighboring gene Mecom adjacent non-protein coding RNA Neighboring gene predicted gene, 52621 Neighboring gene MDS1 and EVI1 complex locus, opposite strand Neighboring gene STARR-seq mESC enhancer starr_07290 Neighboring gene predicted gene 10258 Neighboring gene STARR-seq mESC enhancer starr_07292 Neighboring gene STARR-seq mESC enhancer starr_07293 Neighboring gene STARR-seq mESC enhancer starr_07294 Neighboring gene STARR-positive B cell enhancer ABC_E2661 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene actin related protein T3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells. Leszczyński P, et al. Int J Mol Sci, 2020 Sep 29. PMID 33003409, Free PMC Article
  2. PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response. Ye J, et al. Cell Death Dis, 2020 Mar 16. PMID 32179733, Free PMC Article
  3. Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Juneja SC, et al. Bone, 2014 Mar. PMID 24316420, Free PMC Article
  4. An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation. Ishibashi J, et al. Mol Cell Biol, 2012 Jun. PMID 22473998, Free PMC Article
  5. Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. Kataoka K, et al. J Exp Med, 2011 Nov 21. PMID 22084405, Free PMC Article

See all (152) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
    Title: Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
  2. EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
    Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
  3. Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
    Title: Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
  4. Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
    Title: Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
  5. EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
    Title: EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
  6. PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
    Title: PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
  7. Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.
    Title: Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.
  8. The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
    Title: The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
  9. Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
    Title: Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
  10. All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
    Title: All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183337, MGC184568

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of cell number IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pericardium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ureter morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase MECOM
Names
MDS1 and EVI1 complex locus protein EVI1
MDS1 and EVI1 complex locus protein MDS1
ecotropic viral integration site 1
ecotropic virus integration site 1 protein
myelodysplasia syndrome 1 protein homolog
NP_001347963.1
NP_001357697.1
NP_001357698.1
NP_031989.2
NP_067417.1
XP_006535456.1
XP_006535457.1
XP_011247958.1
XP_011247961.1
XP_011247962.1
XP_011247963.1
XP_011247964.1
XP_011247965.1
XP_011247966.1
XP_017174943.1
XP_030108276.1
XP_036018781.1
XP_036018782.1
XP_036018783.1
XP_036018784.1
XP_036018785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361034.4 → NP_001347963.1  histone-lysine N-methyltransferase MECOM isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419, AL772145, AL929377
    Conserved Domains (6) summary
    PHA00733
    Location:880 → 976
    PHA00733; hypothetical protein
    smart00317
    Location:90 → 194
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:926 → 946
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:924 → 946
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:938 → 962
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:354 → 438
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001370768.3 → NP_001357697.1  histone-lysine N-methyltransferase MECOM isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419, AL772145, AL929377
    Conserved Domains (6) summary
    PHA00733
    Location:848 → 967
    PHA00733; hypothetical protein
    smart00317
    Location:90 → 194
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:917 → 937
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:354 → 438
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam00096
    Location:915 → 937
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:929 → 953
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001370769.3 → NP_001357698.1  histone-lysine N-methyltransferase MECOM isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419, AL772145, AL929377
    UniProtKB/Swiss-Prot
    G3UWT0, P14404, Q9Z1L8
    Conserved Domains (6) summary
    PHA00733
    Location:847 → 966
    PHA00733; hypothetical protein
    smart00317
    Location:90 → 194
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:916 → 936
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:353 → 437
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam00096
    Location:914 → 936
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:928 → 952
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001428445.1 → NP_001415374.1  histone-lysine N-methyltransferase MECOM isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377

  5. NM_001428446.1 → NP_001415375.1  histone-lysine N-methyltransferase MECOM isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377
    UniProtKB/TrEMBL
    H9T841

  6. NM_001428447.1 → NP_001415376.1  histone-lysine N-methyltransferase MECOM isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377
    UniProtKB/TrEMBL
    G3UZT5

  7. NM_001428448.1 → NP_001415377.1  histone-lysine N-methyltransferase MECOM isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377

  8. NM_001428449.1 → NP_001415378.1  histone-lysine N-methyltransferase MECOM isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377

  9. NM_001428450.1 → NP_001415379.1  histone-lysine N-methyltransferase MECOM isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419, AL772145, AL929377

  10. NM_007963.3 → NP_031989.2  histone-lysine N-methyltransferase MECOM isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL772145, AL929377
    Consensus CDS
    CCDS17281.2
    UniProtKB/TrEMBL
    G3UZ13, Q8CCA6
    Related
    ENSMUSP00000134303.2, ENSMUST00000172694.8
    Conserved Domains (4) summary
    PHA00733
    Location:333 → 452
    PHA00733; hypothetical protein
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400 → 422
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:414 → 438
    zf-H2C2_2; Zinc-finger double domain

  11. NM_021442.3 → NP_067417.1  histone-lysine N-methyltransferase MECOM isoform 2

    See identical proteins and their annotated locations for NP_067417.1

    Status: VALIDATED

    Source sequence(s)
    AC119995, AL691419
    UniProtKB/TrEMBL
    F6SZX1
    Related
    ENSMUST00000173022.2
    Conserved Domains (1) summary
    cl02566
    Location:90 → 118
    SET; SET domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30005445..30563937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162888.1 → XP_036018781.1  histone-lysine N-methyltransferase MECOM isoform X4

    Related
    ENSMUSP00000133410.2, ENSMUST00000173899.8
    Conserved Domains (6) summary
    PHA00733
    Location:847 → 966
    PHA00733; hypothetical protein
    COG5189
    Location:304 → 397
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:916 → 936
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:49 → 206
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:914 → 936
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:928 → 952
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011249664.4 → XP_011247966.1  histone-lysine N-methyltransferase MECOM isoform X15

    UniProtKB/TrEMBL
    G3UWJ0
    Conserved Domains (3) summary
    COG5048
    Location:300 → 757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:601 → 621
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:58 → 215
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. XM_011249663.1 → XP_011247965.1  histone-lysine N-methyltransferase MECOM isoform X13

    UniProtKB/TrEMBL
    G3UWJ0
    Related
    ENSMUSP00000133310.2, ENSMUST00000173059.8
    Conserved Domains (3) summary
    COG5048
    Location:263 → 720
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:564 → 584
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:21 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. XM_011249660.3 → XP_011247962.1  histone-lysine N-methyltransferase MECOM isoform X3

    UniProtKB/TrEMBL
    O35700
    Conserved Domains (5) summary
    PHA00733
    Location:851 → 947
    PHA00733; hypothetical protein
    sd00017
    Location:897 → 917
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:895 → 917
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:909 → 933
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:21 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  5. XM_011249656.1 → XP_011247958.1  histone-lysine N-methyltransferase MECOM isoform X1

    Conserved Domains (5) summary
    PHA00733
    Location:851 → 947
    PHA00733; hypothetical protein
    sd00017
    Location:897 → 917
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:895 → 917
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:909 → 933
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:21 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  6. XM_011249662.1 → XP_011247964.1  histone-lysine N-methyltransferase MECOM isoform X12

    UniProtKB/TrEMBL
    G3UWJ0
    Conserved Domains (6) summary
    PHA00733
    Location:528 → 624
    PHA00733; hypothetical protein
    COG5048
    Location:263 → 615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:574 → 594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:572 → 594
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:586 → 610
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:21 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  7. XM_011249659.3 → XP_011247961.1  histone-lysine N-methyltransferase MECOM isoform X2

    UniProtKB/TrEMBL
    O35700
    Conserved Domains (5) summary
    PHA00733
    Location:852 → 948
    PHA00733; hypothetical protein
    sd00017
    Location:898 → 918
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:896 → 918
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:910 → 934
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:21 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  8. XM_011249661.4 → XP_011247963.1  histone-lysine N-methyltransferase MECOM isoform X7

    See identical proteins and their annotated locations for XP_011247963.1

    UniProtKB/TrEMBL
    O35700
    Conserved Domains (4) summary
    PHA00733
    Location:690 → 786
    PHA00733; hypothetical protein
    sd00017
    Location:736 → 756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734 → 756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748 → 772
    zf-H2C2_2; Zinc-finger double domain

  9. XM_036162891.1 → XP_036018784.1  histone-lysine N-methyltransferase MECOM isoform X10

    Related
    ENSMUSP00000103905.4, ENSMUST00000108270.10
    Conserved Domains (5) summary
    PHA00733
    Location:657 → 776
    PHA00733; hypothetical protein
    sd00017
    Location:726 → 746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:724 → 746
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:738 → 762
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:136 → 178
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  10. XM_036162892.1 → XP_036018785.1  histone-lysine N-methyltransferase MECOM isoform X11

    Related
    ENSMUSP00000128563.2, ENSMUST00000166001.8
    Conserved Domains (5) summary
    PHA00733
    Location:657 → 776
    PHA00733; hypothetical protein
    COG5189
    Location:114 → 207
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:726 → 746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:188 → 210
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:738 → 762
    zf-H2C2_2; Zinc-finger double domain

  11. XM_030252416.2 → XP_030108276.1  histone-lysine N-methyltransferase MECOM isoform X8

    Related
    ENSMUSP00000134626.2, ENSMUST00000173495.8
    Conserved Domains (4) summary
    PHA00733
    Location:689 → 785
    PHA00733; hypothetical protein
    sd00017
    Location:735 → 755
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:733 → 755
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:747 → 771
    zf-H2C2_2; Zinc-finger double domain

  12. XM_036162890.1 → XP_036018783.1  histone-lysine N-methyltransferase MECOM isoform X9

    Conserved Domains (4) summary
    PHA00733
    Location:658 → 777
    PHA00733; hypothetical protein
    sd00017
    Location:727 → 747
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:725 → 747
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:739 → 763
    zf-H2C2_2; Zinc-finger double domain

  13. XM_006535394.4 → XP_006535457.1  histone-lysine N-methyltransferase MECOM isoform X7

    Conserved Domains (4) summary
    PHA00733
    Location:690 → 786
    PHA00733; hypothetical protein
    sd00017
    Location:736 → 756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734 → 756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748 → 772
    zf-H2C2_2; Zinc-finger double domain

  14. XM_036162889.1 → XP_036018782.1  histone-lysine N-methyltransferase MECOM isoform X6

    UniProtKB/TrEMBL
    O35700
    Conserved Domains (6) summary
    PHA00733
    Location:753 → 849
    PHA00733; hypothetical protein
    COG5189
    Location:178 → 271
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:799 → 819
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:2 → 80
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:797 → 819
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:811 → 835
    zf-H2C2_2; Zinc-finger double domain

  15. XM_006535393.5 → XP_006535456.1  histone-lysine N-methyltransferase MECOM isoform X5

    UniProtKB/TrEMBL
    O35700
    Conserved Domains (6) summary
    PHA00733
    Location:754 → 850
    PHA00733; hypothetical protein
    sd00017
    Location:800 → 820
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:798 → 820
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:812 → 836
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:228 → 312
    zf-C2H2_8; C2H2-type zinc ribbon
    cl40432
    Location:2 → 80
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  16. XM_017319454.3 → XP_017174943.1  histone-lysine N-methyltransferase MECOM isoform X14

    UniProtKB/TrEMBL
    G3UYK2
    Conserved Domains (4) summary
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:388 → 410
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:288 → 312
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:58 → 215
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14404.2 GenPept UniProtKB/Swiss-Prot:P14404

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