U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Etv1 ets variant 1 [ Mus musculus (house mouse) ]

Gene ID: 14009, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Etv1provided by MGI
Official Full Name
ets variant 1provided by MGI
Primary source
MGI:MGI:99254
See related
Ensembl:ENSMUSG00000004151 AllianceGenome:MGI:99254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ER81; Etsrp81
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including axon guidance; mechanosensory behavior; and positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.2), frontal lobe adult (RPKM 4.0) and 9 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 A3; 12 17.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (38829655..38920484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (38780082..38870483)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, beta Neighboring gene RIKEN cDNA 4930428E07 gene Neighboring gene STARR-seq mESC enhancer starr_31937 Neighboring gene STARR-seq mESC enhancer starr_31938 Neighboring gene STARR-seq mESC enhancer starr_31940 Neighboring gene phosphatidylethanolamine binding protein 2 pseudogene Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 34611

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Rommel C, et al. Circ Res, 2018 Aug 17. PMID 29930145
  2. ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements. Kao YC, et al. Genes Chromosomes Cancer, 2017 Jun. PMID 28233365, Free PMC Article
  3. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Abe H, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746923, Free PMC Article
  4. Differential regulation of dopaminergic gene expression by Er81. Cave JW, et al. J Neurosci, 2010 Mar 31. PMID 20357122, Free PMC Article
  5. Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices. Yoneshima H, et al. Neuroscience, 2006. PMID 16289830

See all (318) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.
    Title: A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.
  2. Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation.
    Title: Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation.
  3. Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
    Title: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
  4. Relationship between ETS Transcription Factor ETV1 and TGF-beta-regulated SMAD Proteins in Prostate Cancer.
    Title: Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.
  5. Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.
    Title: Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.
  6. A cardiomyocyte-autonomous, ETV1-dependent pathway that is responsible for specification of rapid conduction zones in the heart was identified and ETV1 is sufficient to promote a His-Purkinje system transcriptional and functional program upon ventricular myocytes.
    Title: ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.
  7. ETV1 as an important component in the pathophysiology of atrial remodeling associated with atrial arrhythmias.
    Title: The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.
  8. Here, we present a model in which the ETV1 promoter is used to specifically and inducibly drive Cre recombinase in ICC as a strategy to study GIST pathogenesis.
    Title: ETV1-Positive Cells Give Rise to BRAF(V600E) -Mutant Gastrointestinal Stromal Tumors.
  9. Loss of Etv1 resulted in a complete disruption of the normal sodium current heterogeneity that exists between atrial, VCS, and ventricular myocytes.
    Title: Transcription factor ETV1 is essential for rapid conduction in the heart.
  10. we described a RET-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
    Title: A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ETS translocation variant 1
Names
ets variant gene 1
ets-related protein 81

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163154.1 → NP_001156626.1  ETS translocation variant 1 isoform b

    See identical proteins and their annotated locations for NP_001156626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK032224, CD776508
    Consensus CDS
    CCDS49054.1
    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Related
    ENSMUSP00000125676.2, ENSMUST00000159334.8
    Conserved Domains (2) summary
    smart00413
    Location:294 → 378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21 → 293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. NM_001347379.1 → NP_001334308.1  ETS translocation variant 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) has the same N- and C-termini, but is shorter than isoform a.
    Source sequence(s)
    AK032224, AK035914, BB751428, CD776508, CT009742
    Consensus CDS
    CCDS83959.1
    UniProtKB/TrEMBL
    E0CZ54
    Related
    ENSMUSP00000125692.2, ENSMUST00000160856.8

  3. NM_007960.5 → NP_031986.1  ETS translocation variant 1 isoform a

    See identical proteins and their annotated locations for NP_031986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK032224, AK035914, BB751428, CD776508, CT009742
    Consensus CDS
    CCDS49053.1
    UniProtKB/Swiss-Prot
    P41164
    UniProtKB/TrEMBL
    Q549J8
    Related
    ENSMUSP00000093442.4, ENSMUST00000095767.11
    Conserved Domains (2) summary
    smart00413
    Location:334 → 418
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 333
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    38829655..38920484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514968.5 → XP_006515031.1  ETS translocation variant 1 isoform X4

    See identical proteins and their annotated locations for XP_006515031.1

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294 → 378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21 → 293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. XM_006514965.4 → XP_006515028.1  ETS translocation variant 1 isoform X2

    See identical proteins and their annotated locations for XP_006515028.1

    UniProtKB/Swiss-Prot
    P41164
    UniProtKB/TrEMBL
    Q549J8
    Conserved Domains (2) summary
    smart00413
    Location:334 → 418
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 333
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  3. XM_036157184.1 → XP_036013077.1  ETS translocation variant 1 isoform X4

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294 → 378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21 → 293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  4. XM_006514964.5 → XP_006515027.1  ETS translocation variant 1 isoform X1

    Conserved Domains (2) summary
    smart00413
    Location:350 → 434
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:31 → 349
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  5. XM_036157185.1 → XP_036013078.1  ETS translocation variant 1 isoform X4

    UniProtKB/TrEMBL
    E0CYN8, Q8CCR6
    Conserved Domains (2) summary
    smart00413
    Location:294 → 378
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21 → 293
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  6. XM_006514966.5 → XP_006515029.1  ETS translocation variant 1 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:332 → 416
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:31 → 331
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  7. XM_036157186.1 → XP_036013079.1  ETS translocation variant 1 isoform X7

    UniProtKB/TrEMBL
    E0CXD2, E0CYN8
    Related
    ENSMUSP00000124736.2, ENSMUST00000161980.8
    Conserved Domains (2) summary
    smart00413
    Location:276 → 360
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:21 → 275
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  8. XM_006514972.5 → XP_006515035.1  ETS translocation variant 1 isoform X8

    Conserved Domains (2) summary
    smart00413
    Location:203 → 287
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:4 → 202
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  9. XM_006514970.5 → XP_006515033.1  ETS translocation variant 1 isoform X6

    UniProtKB/TrEMBL
    E0CYN8
    Conserved Domains (2) summary
    smart00413
    Location:278 → 362
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 277
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  10. XM_006514969.5 → XP_006515032.1  ETS translocation variant 1 isoform X5

    Conserved Domains (2) summary
    smart00413
    Location:279 → 363
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:24 → 278
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41164.1 GenPept UniProtKB/Swiss-Prot:P41164

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous