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Fgd6 FYVE, RhoGEF and PH domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 13998, updated on 11-Apr-2024

Summary

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Official Symbol
Fgd6provided by MGI
Official Full Name
FYVE, RhoGEF and PH domain containing 6provided by MGI
Primary source
MGI:MGI:1261419
See related
Ensembl:ENSMUSG00000020021 AllianceGenome:MGI:1261419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etohd4; ZFYVE24
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human FGD6 (FYVE, RhoGEF and PH domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 4.7), placenta adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 48.76 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93871862..93981201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94035979..94145339)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene STARR-positive B cell enhancer ABC_E1811 Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93661580-93661763 Neighboring gene predicted gene, 26122 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts. Steenblock C, et al. J Biol Chem, 2014 Jun 27. PMID 24821726, Free PMC Article
  2. Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Rout UK, et al. Cell Calcium, 1997 Dec. PMID 9502196
  3. The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Vezzali R, et al. Oncotarget, 2016 Jun 21. PMID 27224923, Free PMC Article
  4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.
    Title: The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 6
Names
ethanol decreased 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053072.3 → NP_444302.4  FYVE, RhoGEF and PH domain-containing protein 6

    See identical proteins and their annotated locations for NP_444302.4

    Status: VALIDATED

    Source sequence(s)
    AK044341, AK173157, BF464747
    Consensus CDS
    CCDS48674.1
    UniProtKB/Swiss-Prot
    Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7
    UniProtKB/TrEMBL
    B2RSV7
    Related
    ENSMUSP00000020208.5, ENSMUST00000020208.5
    Conserved Domains (5) summary
    cd13237
    Location:1305 → 1393
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15793
    Location:1047 → 1169
    PH1_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin Homology (PH) domain
    cd15743
    Location:1186 → 1246
    FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
    pfam00169
    Location:1304 → 1395
    PH; PH domain
    pfam00621
    Location:845 → 1029
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93871862..93981201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155591.1 → XP_036011484.1  FYVE, RhoGEF and PH domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    B2RSV7
    Conserved Domains (4) summary
    cd13237
    Location:1307 → 1395
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15743
    Location:1188 → 1248
    FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
    pfam00621
    Location:845 → 1028
    RhoGEF; RhoGEF domain
    cl17171
    Location:1047 → 1171
    PH-like; Pleckstrin homology-like domain

  2. XM_036155592.1 → XP_036011485.1  FYVE, RhoGEF and PH domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    B2RSV7
    Conserved Domains (4) summary
    cd13237
    Location:1259 → 1347
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cl28890
    Location:1168 → 1200
    FYVE_like_SF; FYVE domain like superfamily
    pfam00621
    Location:845 → 1028
    RhoGEF; RhoGEF domain
    cl17171
    Location:1047 → 1171
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_004936096.1 RNA Sequence

  2. XR_004936097.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZL1.2 GenPept UniProtKB/Swiss-Prot:Q69ZL1

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