U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PAGE3 PAGE family member 3 [ Homo sapiens (human) ]

Gene ID: 139793, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PAGE3provided by HGNC
Official Full Name
PAGE family member 3provided by HGNC
Primary source
HGNC:HGNC:4110
See related
Ensembl:ENSG00000204279 MIM:300739; AllianceGenome:HGNC:4110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT16.6; GAGED1; PAGE-3
Summary
This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2015]
Expression
Restricted expression toward testis (RPKM 1.3) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PAGE3 in Genome Data Viewer
Location:
Xp11.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55258415..55264916, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54551564..54558062, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55284848..55291349, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene small nucleolar RNA, H/ACA box 109 Neighboring gene PAGE family member 5 Neighboring gene PAGE family member 5 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:55368751-55369252 Neighboring gene microRNA 4536-1 Neighboring gene microRNA 4536-2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. Brinkmann U, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724777, Free PMC Article
  2. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
P antigen family member 3
Names
G antigen family D member 1
G antigen, family D, 1
P antigen family, member 3 (prostate associated)
prostate-associated gene 3 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017195.2 RefSeqGene

    Range
    5000..11501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017931.3 → NP_001017931.3  P antigen family member 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL158819
    Consensus CDS
    CCDS35307.1
    UniProtKB/Swiss-Prot
    A5D6Y1, Q5JUK9
    Related
    ENSP00000364089.1, ENST00000374951.6
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

  2. NM_001171252.2 → NP_001164723.2  P antigen family member 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL158819
    Consensus CDS
    CCDS35307.1
    UniProtKB/Swiss-Prot
    A5D6Y1, Q5JUK9
    Related
    ENSP00000429571.1, ENST00000519203.1
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

  3. NM_001303613.2 → NP_001290542.2  P antigen family member 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL158819
    Consensus CDS
    CCDS35307.1
    UniProtKB/Swiss-Prot
    A5D6Y1, Q5JUK9
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55258415..55264916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029282.3 → XP_016884771.1  P antigen family member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5D6Y1, Q5JUK9
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    54551564..54558062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326505.1 → XP_054182480.1  P antigen family member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5D6Y1, Q5JUK9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JUK9.1 GenPept UniProtKB/Swiss-Prot:Q5JUK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous