U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OR1L8 olfactory receptor family 1 subfamily L member 8 [ Homo sapiens (human) ]

Gene ID: 138881, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
OR1L8provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily L member 8provided by HGNC
Primary source
HGNC:HGNC:15110
See related
Ensembl:ENSG00000171496 AllianceGenome:HGNC:15110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR9-24
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See OR1L8 in Genome Data Viewer
Location:
9q33.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122546271..122583384, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134764443..134780693, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125329396..125345663, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily J member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:125299684-125300883 Neighboring gene olfactory receptor family 1 subfamily J member 4 Neighboring gene olfactory receptor family 1 subfamily N member 1 Neighboring gene olfactory receptor family 1 subfamily N member 2 Neighboring gene uncharacterized LOC124902265 Neighboring gene olfactory receptor family 1 subfamily H member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily Q member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
olfactory receptor 1L8
Names
olfactory receptor OR9-24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004454.2 → NP_001004454.1  olfactory receptor 1L8

    See identical proteins and their annotated locations for NP_001004454.1

    Status: VALIDATED

    Source sequence(s)
    AL162254, AL359636
    Consensus CDS
    CCDS35124.1
    UniProtKB/Swiss-Prot
    A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
    UniProtKB/TrEMBL
    A0A126GVC5
    Related
    ENSP00000493411.1, ENST00000641027.1
    Conserved Domains (2) summary
    pfam00001
    Location:42 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 308
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    122546271..122583384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014285.2 → XP_016869774.1  olfactory receptor 1L8 isoform X1

    UniProtKB/Swiss-Prot
    A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
    UniProtKB/TrEMBL
    A0A126GVC5
    Conserved Domains (2) summary
    pfam00001
    Location:42 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 308
    7tm_4; Olfactory receptor

  2. XM_017014286.2 → XP_016869775.1  olfactory receptor 1L8 isoform X1

    UniProtKB/Swiss-Prot
    A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
    UniProtKB/TrEMBL
    A0A126GVC5
    Conserved Domains (2) summary
    pfam00001
    Location:42 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 308
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    134764443..134780693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGR8.1 GenPept UniProtKB/Swiss-Prot:Q8NGR8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous