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Esd esterase D/formylglutathione hydrolase [ Mus musculus (house mouse) ]

Gene ID: 13885, updated on 11-Apr-2024

Summary

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Official Symbol
Esdprovided by MGI
Official Full Name
esterase D/formylglutathione hydrolaseprovided by MGI
Primary source
MGI:MGI:95421
See related
Ensembl:ENSMUSG00000021996 AllianceGenome:MGI:95421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FGH; Es10; Es-10; sid478
Summary
Enables hydrolase activity, acting on ester bonds. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 38.8), placenta adult (RPKM 36.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 39.38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (74969591..74988205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (74732151..74750765)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A Neighboring gene STARR-positive B cell enhancer ABC_E5454 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 1 Neighboring gene predicted gene, 52135 Neighboring gene STARR-positive B cell enhancer ABC_E5455 Neighboring gene STARR-positive B cell enhancer ABC_E9901 Neighboring gene STARR-positive B cell enhancer ABC_E8571 Neighboring gene predicted gene 10847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polymorphism of esterase-10 in Mus musculus. Peters J, et al. Biochem Genet, 1976 Feb. PMID 1259699
  2. Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats. Ono T, et al. Jpn J Genet, 1995 Feb. PMID 7772379
  3. A new mutant hairless mouse with lymph node hyperplasia and late onset of autoimmune pathology. Massironi SM, et al. Braz J Med Biol Res, 1994 Oct. PMID 7640630
  4. Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Lukey T, et al. Biochem Genet, 1985 Apr. PMID 3925939
  5. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Leinwand L, et al. Cytogenet Cell Genet, 1978. PMID 206412

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-formylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on ester bonds IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, acting on ester bonds ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in formaldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic substance catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-formylglutathione hydrolase
Names
Sid 478
esterase 10
esterase D
NP_001272352.1
NP_058599.1
XP_006518606.1
XP_030103505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285423.1 → NP_001272352.1  S-formylglutathione hydrolase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154621
    Consensus CDS
    CCDS70603.1
    UniProtKB/TrEMBL
    H3BKH6, H3BLJ9
    Related
    ENSMUSP00000135394.2, ENSMUST00000176957.8
    Conserved Domains (2) summary
    PLN02442
    Location:15 → 294
    PLN02442; S-formylglutathione hydrolase
    COG0627
    Location:13 → 295
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]

  2. NM_016903.5 → NP_058599.1  S-formylglutathione hydrolase isoform 2

    See identical proteins and their annotated locations for NP_058599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154621, AK010683, AK163074
    Consensus CDS
    CCDS36975.1
    UniProtKB/Swiss-Prot
    Q80ZX4, Q9CWI4, Q9R0P3
    UniProtKB/TrEMBL
    H3BLJ9
    Related
    ENSMUSP00000022573.11, ENSMUST00000022573.17
    Conserved Domains (2) summary
    PLN02442
    Location:2 → 281
    PLN02442; S-formylglutathione hydrolase
    COG0627
    Location:1 → 282
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    74969591..74988205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247645.1 → XP_030103505.1  S-formylglutathione hydrolase isoform X2

    UniProtKB/TrEMBL
    H3BK43, H3BLJ9
    Related
    ENSMUSP00000135244.2, ENSMUST00000175887.8
    Conserved Domains (1) summary
    cl21494
    Location:2 → 248
    Abhydrolase; alpha/beta hydrolases

  2. XM_006518543.3 → XP_006518606.1  S-formylglutathione hydrolase isoform X1

    UniProtKB/TrEMBL
    H3BLJ9
    Conserved Domains (1) summary
    cl21494
    Location:15 → 261
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0P3.1 GenPept UniProtKB/Swiss-Prot:Q9R0P3

Gene LinkOut

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