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Erg ETS transcription factor [ Mus musculus (house mouse) ]

Gene ID: 13876, updated on 11-Apr-2024

Summary

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Official Symbol
Ergprovided by MGI
Official Full Name
ETS transcription factorprovided by MGI
Primary source
MGI:MGI:95415
See related
Ensembl:ENSMUSG00000040732 AllianceGenome:MGI:95415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030036I24Rik
Summary
Enables chromatin binding activity. Acts upstream of or within cell migration; mesenchyme development; and positive regulation of blood vessel remodeling. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and skeleton. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 16.0), limb E14.5 (RPKM 8.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Erg in Genome Data Viewer
Location:
16 C4; 16 56.04 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95160028..95387452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95359169..95586600, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31641 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:95484660-95484843 Neighboring gene predicted gene, 31754 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95563080-95563380 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95572113-95572413 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95581838-95582139 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95649181-95649482 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95650074-95650374 Neighboring gene STARR-seq mESC enhancer starr_41600 Neighboring gene STARR-seq mESC enhancer starr_41602 Neighboring gene predicted gene, 31845 Neighboring gene predicted gene, 31901

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Caporarello N, et al. Nat Commun, 2022 Jul 25. PMID 35879310, Free PMC Article
  2. ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer. Shah N, et al. Cancer Res, 2020 Nov 1. PMID 32934023
  3. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Xie Y, et al. Stem Cells, 2017 Jul. PMID 28436588, Free PMC Article
  4. Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model. Ng AP, et al. PLoS Genet, 2015 May. PMID 25973911, Free PMC Article
  5. Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice. Flajollet S, et al. PLoS One, 2012. PMID 23155398, Free PMC Article

See all (169) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
    Title: ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
  2. Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
    Title: Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
  3. SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
    Title: SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
  4. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
    Title: Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
  5. EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
    Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
  6. ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
    Title: ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
  7. ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3beta dependent Nkx3.1 degradation.
    Title: ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.
  8. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
    Title: EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
  9. Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
    Title: Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
  10. ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.
    Title: ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcriptional regulator ERG
Names
avian erythroblastosis virus E-26 (v-ets) oncogene related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302152.1 → NP_001289081.1  transcriptional regulator ERG isoform 2

    See identical proteins and their annotated locations for NP_001289081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a longer 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC154691, AK050922, AK078113, BP753340
    Consensus CDS
    CCDS79495.1
    UniProtKB/TrEMBL
    B7ZND3, B7ZND4
    Related
    ENSMUSP00000156926.2, ENSMUST00000233269.2
    Conserved Domains (2) summary
    smart00413
    Location:293 → 376
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_001302153.1 → NP_001289082.1  transcriptional regulator ERG isoform 3

    See identical proteins and their annotated locations for NP_001289082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC154691, AK078113, AK142379, BB639043, BP753340
    Consensus CDS
    CCDS79493.1
    UniProtKB/TrEMBL
    B7ZND3, Q3UQJ4
    Related
    ENSMUSP00000114072.4, ENSMUST00000122199.10
    Conserved Domains (2) summary
    smart00413
    Location:310 → 393
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

  3. NM_001302154.1 → NP_001289083.1  transcriptional regulator ERG isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC154691, AK078113, BB639043, BP753340
    Consensus CDS
    CCDS79492.1
    UniProtKB/TrEMBL
    A0A384DVA0, B7ZND3
    Related
    ENSMUSP00000156927.2, ENSMUST00000233664.2
    Conserved Domains (2) summary
    smart00413
    Location:287 → 370
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

  4. NM_001302179.1 → NP_001289108.1  transcriptional regulator ERG isoform 5

    See identical proteins and their annotated locations for NP_001289108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter compared to isoform 1.
    Source sequence(s)
    AC154691, AK050922, AK078113, BP753340
    Consensus CDS
    CCDS79496.1
    UniProtKB/TrEMBL
    B7ZND3
    Related
    ENSMUSP00000109479.5, ENSMUST00000113848.11
    Conserved Domains (2) summary
    smart00413
    Location:294 → 377
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  5. NM_001302183.1 → NP_001289112.1  transcriptional regulator ERG isoform 6

    See identical proteins and their annotated locations for NP_001289112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) is shorter compared to isoform 1.
    Source sequence(s)
    AC154691, AK050922, AK078113, BP753340
    Consensus CDS
    CCDS79494.1
    UniProtKB/TrEMBL
    B7ZND3, E9PY05
    Related
    ENSMUSP00000132766.2, ENSMUST00000171646.10
    Conserved Domains (2) summary
    smart00413
    Location:270 → 353
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  6. NM_133659.3 → NP_598420.1  transcriptional regulator ERG isoform 1

    See identical proteins and their annotated locations for NP_598420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154691, AK050922, AK078113, BP753340
    Consensus CDS
    CCDS37411.1
    UniProtKB/Swiss-Prot
    A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
    UniProtKB/TrEMBL
    B7ZND3
    Related
    ENSMUSP00000156669.2, ENSMUST00000233881.2
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    95160028..95387452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522895.3 → XP_006522958.1  transcriptional regulator ERG isoform X2

    See identical proteins and their annotated locations for XP_006522958.1

    UniProtKB/Swiss-Prot
    A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_006522903.3 → XP_006522966.1  transcriptional regulator ERG isoform X6

    See identical proteins and their annotated locations for XP_006522966.1

    UniProtKB/TrEMBL
    B7ZND3, E9PY05
    Conserved Domains (2) summary
    smart00413
    Location:270 → 353
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  3. XM_006522900.3 → XP_006522963.1  transcriptional regulator ERG isoform X4

    See identical proteins and their annotated locations for XP_006522963.1

    UniProtKB/TrEMBL
    B7ZND3, B7ZND4
    Conserved Domains (2) summary
    smart00413
    Location:293 → 376
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  4. XM_006522899.3 → XP_006522962.1  transcriptional regulator ERG isoform X3

    See identical proteins and their annotated locations for XP_006522962.1

    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:294 → 377
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  5. XM_006522894.3 → XP_006522957.1  transcriptional regulator ERG isoform X2

    See identical proteins and their annotated locations for XP_006522957.1

    UniProtKB/Swiss-Prot
    A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  6. XM_006522896.5 → XP_006522959.1  transcriptional regulator ERG isoform X2

    See identical proteins and their annotated locations for XP_006522959.1

    UniProtKB/Swiss-Prot
    A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  7. XM_030248973.2 → XP_030104833.1  transcriptional regulator ERG isoform X7

    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:263 → 346
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

  8. XM_030248972.2 → XP_030104832.1  transcriptional regulator ERG isoform X5

    UniProtKB/TrEMBL
    B7ZND3, I1E4Y2
    Related
    ENSMUSP00000113723.5, ENSMUST00000121809.11
    Conserved Domains (2) summary
    smart00413
    Location:286 → 369
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

  9. XM_006522904.5 → XP_006522967.1  transcriptional regulator ERG isoform X8

    See identical proteins and their annotated locations for XP_006522967.1

    UniProtKB/TrEMBL
    H3BKX4
    Related
    ENSMUSP00000135568.4, ENSMUST00000176345.10
    Conserved Domains (2) summary
    smart00413
    Location:278 → 361
    ETS; erythroblast transformation specific domain
    cl15755
    Location:83 → 166
    SAM_superfamily; SAM (Sterile alpha motif )

  10. XM_036159777.1 → XP_036015670.1  transcriptional regulator ERG isoform X1

    UniProtKB/TrEMBL
    B7ZND3
    Conserved Domains (2) summary
    smart00413
    Location:212 → 295
    ETS; erythroblast transformation specific domain
    cl15755
    Location:83 → 166
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81270.2 GenPept UniProtKB/Swiss-Prot:P81270

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