Erbb3 erb-b2 receptor tyrosine kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erbb3provided by MGI
Official Full Name: erb-b2 receptor tyrosine kinase 3provided by MGI
Primary source: MGI:MGI:95411
See related: Ensembl:ENSMUSG00000018166 AllianceGenome:MGI:95411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Her3; Erbb-3; Erbb3r
Summary: Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.1 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128403392..128425504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128567523..128589635, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
Title: MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR.
Title: Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR.
ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.
Title: ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.
The kinase-inactive Erbb3 mutant mice showed normal recovery.
Title: Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis.
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1), which acts on luminal cells via Erbb3 and Erbb4 receptors.
Title: Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.
The authors demonstrate that ErbB3 signaling is required for the embryonic development of the enteric nervous system.
Title: Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.
These studies demonstrate that ErbB3, like ErbB4, enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt and STAT5A, two targets crucial for lactation.
Title: ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.
The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
Title: The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.
Our results support a role for the hepatocellular ERBB tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR-ERBB3 DKO models, suggesting that EGFR-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR homodimeric signaling.
Title: Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Title: Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Erbb3 (e-PCR), detects polymorphism
- UniSTS:468003

C76256 (e-PCR)
- UniSTS:160044

NoName (e-PCR)
- UniSTS:548399

Erbb3 (e-PCR), detects polymorphism
- UniSTS:143004

NoName (e-PCR)
- UniSTS:236490

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables neuregulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuregulin binding	ISO Inferred from Sequence Orthology more info
enables neuregulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuregulin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuregulin receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
NOT enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cranial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ERBB3:ERBB2 complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-3

Names: avian erythroblastosis oncogene B 3 receptor; c-erbB-3; glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

NP_034283.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010153.2 → NP_034283.1 receptor tyrosine-protein kinase erbB-3 precursor

See identical proteins and their annotated locations for NP_034283.1

Status: VALIDATED

Source sequence(s)

AA119766, AC117232, BC106091

Consensus CDS

CCDS24283.1

UniProtKB/Swiss-Prot

Q3KQR1, Q61526, Q68J64, Q810U8, Q8K317

Related

ENSMUSP00000080716.7, ENSMUST00000082059.7

Conserved Domains (8) summary

cd12095
Location:638 → 674

TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase

smart00261
Location:548 → 592

FU; Furin-like repeats

cd00064
Location:226 → 266

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:179 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:353 → 474

Recep_L_domain; Receptor L domain

pfam07714
Location:707 → 963

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:499 → 630

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:699 → 977

PKc_like; Protein Kinases, catalytic domain