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Ephb4 Eph receptor B4 [ Mus musculus (house mouse) ]

Gene ID: 13846, updated on 11-Apr-2024

Summary

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Official Symbol
Ephb4provided by MGI
Official Full Name
Eph receptor B4provided by MGI
Primary source
MGI:MGI:104757
See related
Ensembl:ENSMUSG00000029710 AllianceGenome:MGI:104757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Htk; MDK2; Myk1; Tyro11; b2b2412Clo
Summary
Predicted to enable transmembrane-ephrin receptor activity. Involved in angiogenesis; ephrin receptor signaling pathway; and heart morphogenesis. Acts upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 50.3), limb E14.5 (RPKM 38.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ephb4 in Genome Data Viewer
Location:
5 G2; 5 76.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137348371..137372784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137350109..137374522)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 9 Neighboring gene STARR-positive B cell enhancer ABC_E9655 Neighboring gene STARR-seq mESC enhancer starr_14641 Neighboring gene predicted gene, 52791 Neighboring gene STARR-seq mESC enhancer starr_14643 Neighboring gene zonadhesin Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insulin induces insulin receptor degradation in the liver through EphB4. Liu X, et al. Nat Metab, 2022 Sep. PMID 36131205
  2. Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke. Wang J, et al. Mol Med Rep, 2021 Nov. PMID 34476505, Free PMC Article
  3. EphB4 inhibitor overcome the acquired resistance to cisplatin in melanomas xenograft model. Yang X, et al. J Pharmacol Sci, 2015 Sep. PMID 26390965
  4. EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice. Wang Y, et al. J Biol Chem, 2015 May 29. PMID 25903126, Free PMC Article
  5. The in vivo effect of prophylactic subchondral bone protection of osteoarthritic synovial membrane in bone-specific Ephb4-overexpressing mice. Valverde-Franco G, et al. Am J Pathol, 2015 Feb. PMID 25453723

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortiondagger.
    Title: EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†.
  2. Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
    Title: Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
  3. Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
    Title: Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
  4. Insulin induces insulin receptor degradation in the liver through EphB4.
    Title: Insulin induces insulin receptor degradation in the liver through EphB4.
  5. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
    Title: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
  6. Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
    Title: Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
  7. Mutations in EPHB4 cause human venous valve aplasia.
    Title: Mutations in EPHB4 cause human venous valve aplasia.
  8. Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
    Title: Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
  9. Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
    Title: Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
  10. Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
    Title: Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of T cell costimulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within venous blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ephrin type-B receptor 4
Names
developmental kinase 2
hepatoma transmembrane kinase
mDK-2
tyrosine kinase MYK-1
NP_001153043.1
NP_034274.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159571.1 → NP_001153043.1  ephrin type-B receptor 4 isoform a precursor

    See identical proteins and their annotated locations for NP_001153043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK046884, AK049340, BB677774
    Consensus CDS
    CCDS51671.1
    UniProtKB/TrEMBL
    Q3V1K8, Q8C7S3, Q8C8K1
    Related
    ENSMUSP00000106684.3, ENSMUST00000111055.9
    Conserved Domains (7) summary
    cd05065
    Location:619 → 887
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:916 → 982
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    smart00454
    Location:913 → 980
    SAM; Sterile alpha motif
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:443 → 535
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:624 → 883
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:571 → 619
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. NM_010144.6 → NP_034274.4  ephrin type-B receptor 4 isoform b precursor

    See identical proteins and their annotated locations for NP_034274.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AK049340, AK132392, BB677774, BC090839
    Consensus CDS
    CCDS19767.1
    UniProtKB/Swiss-Prot
    P54761, Q60627, Q99MR2
    UniProtKB/TrEMBL
    Q3V1K8, Q8C7S3
    Related
    ENSMUSP00000051622.9, ENSMUST00000061244.15
    Conserved Domains (7) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    smart00454
    Location:904 → 971
    SAM; Sterile alpha motif
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:615 → 874
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137348371..137372784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54761.2 GenPept UniProtKB/Swiss-Prot:P54761

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