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Epha5 Eph receptor A5 [ Mus musculus (house mouse) ]

Gene ID: 13839, updated on 11-Apr-2024

Summary

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Official Symbol
Epha5provided by MGI
Official Full Name
Eph receptor A5provided by MGI
Primary source
MGI:MGI:99654
See related
Ensembl:ENSMUSG00000029245 AllianceGenome:MGI:99654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bsk; Cek7; Ehk1; Els1; Hek7; Rek7
Summary
Enables GPI-linked ephrin receptor activity. Involved in several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus and cellular response to forskolin. Located in adherens junction and cell periphery. Is expressed in several structures, including future midbrain; genitourinary system; nervous system; sensory organ; and upper jaw. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.2), frontal lobe adult (RPKM 7.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E1; 5 43.0 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (84199024..84565677, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (84054761..84417818, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13526 Neighboring gene mitochondrial ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13527 Neighboring gene STARR-seq mESC enhancer starr_13528 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13529 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_13530 Neighboring gene STARR-seq mESC enhancer starr_13531 Neighboring gene STARR-seq mESC enhancer starr_13532 Neighboring gene predicted gene, 42163 Neighboring gene WD repeat domain 12 pseudogene Neighboring gene phosphoglycerate kinase 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities. Noh H, et al. Mol Cells, 2014 Jan. PMID 24552711, Free PMC Article
  2. Distribution of EphA5 receptor protein in the developing and adult mouse nervous system. Cooper MA, et al. J Comp Neurol, 2009 Jun 1. PMID 19326470, Free PMC Article
  3. Changes in attack behavior and activity in EphA5 knockout mice. Mamiya PC, et al. Brain Res, 2008 Apr 18. PMID 18353288, Free PMC Article
  4. Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes. Fukushima K, et al. Am J Physiol Gastrointest Liver Physiol, 2006 Nov. PMID 16782697
  5. Disruption of ephrin-A/EphA binding alters synaptogenesis and neural connectivity in the hippocampus. Martínez A, et al. Neuroscience, 2005. PMID 16112477

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
    Title: Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
  2. Observations suggest that ephrin-A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.
    Title: Decreased maternal behavior and anxiety in ephrin-A5(-/-) mice.
  3. methylation of only six of 98 CpG dinucleotides within the EphA5 promoter blocks its transactivation by KLF16 but enables transactivation by KLF2 and KLF15.
    Title: Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.
  4. We examined the roles of ephrin-A2 and ephrin-A5 signaling in contralateral targeting and topographic ordering in the ventral cochlear nucleus
    Title: Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.
  5. Expression of ephrinA5-Fc decreases a population of cephalic neural crest precursors in the dorsal midline of the dien- and mesencephalon.
    Title: In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities.
  6. ephrinA5/EphA3 triggers proteolysis of the neural cell adhesion molecule (NCAM) by the metalloprotease a disintegrin and metalloprotease (ADAM)10 to promote growth cone collapse in neurons from mouse neocortex.
    Title: EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.
  7. Results demonstrated that the ephrinA5-EphA4/EphA5 system plays an important role in the direct pathway-dependent regulation of the SNr in cocaine responses and would provide valuable therapeutic targets of cocaine addiction.
    Title: Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses.
  8. ephrin-A5 and EphA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
    Title: Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.
  9. We characterized EphA5 protein during development and conclude that EphA5 function is not limited to the developing mouse brain and may play a role in synaptic plasticity in the adult.
    Title: Distribution of EphA5 receptor protein in the developing and adult mouse nervous system.
  10. EphA5 receptor may be involved in mediation of aggressive behavior regulated, in part, by hypothalamic serotonin
    Title: Changes in attack behavior and activity in EphA5 knockout mice.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GPI-linked ephrin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to forskolin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hippocampus development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 5
Names
EPH homology kinase 1
brain-specific kinase
eck-like sequence 1
NP_001389678.1
NP_001389679.1
NP_001389680.1
NP_001389681.1
NP_001389682.1
NP_001389683.1
NP_001389684.1
NP_001389685.1
NP_001389686.1
NP_001389687.1
NP_001389688.1
NP_001389689.1
NP_001389690.1
NP_031963.2
XP_006534832.1
XP_030109983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402749.1 → NP_001389678.1  ephrin type-A receptor 5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597
    Related
    ENSMUSP00000109033.2, ENSMUST00000113406.8

  2. NM_001402750.1 → NP_001389679.1  ephrin type-A receptor 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597
    UniProtKB/TrEMBL
    E9PUQ2
    Related
    ENSMUSP00000109026.2, ENSMUST00000113399.6

  3. NM_001402751.1 → NP_001389680.1  ephrin type-A receptor 5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  4. NM_001402752.1 → NP_001389681.1  ephrin type-A receptor 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  5. NM_001402753.1 → NP_001389682.1  ephrin type-A receptor 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  6. NM_001402754.1 → NP_001389683.1  ephrin type-A receptor 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  7. NM_001402755.1 → NP_001389684.1  ephrin type-A receptor 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597
    UniProtKB/TrEMBL
    E9PUQ4
    Related
    ENSMUSP00000109025.2, ENSMUST00000113398.8

  8. NM_001402756.1 → NP_001389685.1  ephrin type-A receptor 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  9. NM_001402757.1 → NP_001389686.1  ephrin type-A receptor 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  10. NM_001402758.1 → NP_001389687.1  ephrin type-A receptor 5 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  11. NM_001402759.1 → NP_001389688.1  ephrin type-A receptor 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597

  12. NM_001402760.1 → NP_001389689.1  ephrin type-A receptor 5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597
    UniProtKB/TrEMBL
    Q6PFV6
    Related
    ENSMUSP00000109028.2, ENSMUST00000113401.4

  13. NM_001402761.1 → NP_001389690.1  ephrin type-A receptor 5 isoform 14 precursor

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC129220, AC132597

  14. NM_007937.3 → NP_031963.2  ephrin type-A receptor 5 isoform 8 precursor

    See identical proteins and their annotated locations for NP_031963.2

    Status: VALIDATED

    Source sequence(s)
    AC101956, AC114638, AC129220, AC132597
    Consensus CDS
    CCDS19376.1
    UniProtKB/Swiss-Prot
    E9QPV2, Q60629
    UniProtKB/TrEMBL
    E9PUP9
    Related
    ENSMUSP00000060646.9, ENSMUST00000053733.15
    Conserved Domains (7) summary
    cd09546
    Location:804 → 869
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    smart00454
    Location:808 → 866
    SAM; Sterile alpha motif
    cd00063
    Location:307 → 397
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:509 → 775
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:514 → 771
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:417 → 509
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:62 → 234
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    84199024..84565677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534769.3 → XP_006534832.1  ephrin type-A receptor 5 isoform X1

    UniProtKB/TrEMBL
    E9PUP9, E9PUQ0
    Related
    ENSMUSP00000109030.2, ENSMUST00000113403.8
    Conserved Domains (5) summary
    cd09546
    Location:968 → 1033
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    cd00063
    Location:471 → 561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:673 → 939
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:581 → 673
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:62 → 234
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

  2. XM_030254123.2 → XP_030109983.1  ephrin type-A receptor 5 isoform X3

    UniProtKB/TrEMBL
    E9PUP9
    Conserved Domains (5) summary
    cd09546
    Location:897 → 962
    SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
    cd00063
    Location:400 → 490
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:602 → 868
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:510 → 602
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 163
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60629.2 GenPept UniProtKB/Swiss-Prot:Q60629

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