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Eno3 enolase 3, beta muscle [ Mus musculus (house mouse) ]

Gene ID: 13808, updated on 11-Apr-2024

Summary

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Official Symbol
Eno3provided by MGI
Official Full Name
enolase 3, beta muscleprovided by MGI
Primary source
MGI:MGI:95395
See related
Ensembl:ENSMUSG00000060600 AllianceGenome:MGI:95395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSE; Eno-3
Summary
This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Biased expression in heart adult (RPKM 242.7), mammary gland adult (RPKM 95.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 43.21 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70543973..70553339)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70653125..70662513)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 1b, alpha polypeptide Neighboring gene solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 Neighboring gene STARR-positive B cell enhancer ABC_E1422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70460970-70461079 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70461301-70461410 Neighboring gene STARR-positive B cell enhancer ABC_E7008 Neighboring gene ring finger protein 167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70465643-70465931 Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene sperm associated antigen 7 Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene calmodulin binding transcription activator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interactions of enolase isoforms with tubulin and microtubules during myogenesis. Keller A, et al. Biochim Biophys Acta, 2007 Jun. PMID 17368730
  2. Differential modulation of alpha, beta and gamma enolase isoforms in regenerating mouse skeletal muscle. Merkulova T, et al. Eur J Biochem, 2000 Jun. PMID 10848992
  3. Transcriptional up-regulation of the mouse gene for the muscle-specific subunit of enolase during terminal differentiation of myogenic cells. Lamandé N, et al. Mol Reprod Dev, 1995 Jul. PMID 8588929
  4. Conserved alternative splicing in the 5'-untranslated region of the muscle-specific enolase gene. Primary structure of mRNAs, expression and influence of secondary structure on the translation efficiency. Oliva D, et al. Eur J Biochem, 1995 Aug 15. PMID 7556143
  5. Murine muscle-specific enolase: cDNA cloning, sequence, and developmental expression. Lamandé N, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 2734297, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphopyruvate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-enolase
Names
2-phospho-D-glycerate hydro-lyase
muscle-specific enolase
skeletal muscle enolase
NP_001129534.1
NP_001263214.1
NP_031959.1
XP_006532224.1
XP_006532225.1
XP_030101387.1
XP_036012183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136062.2 → NP_001129534.1  beta-enolase

    See identical proteins and their annotated locations for NP_001129534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AI841640, AK002485, BY784892
    Consensus CDS
    CCDS24961.1
    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Related
    ENSMUSP00000072620.6, ENSMUST00000072841.12
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase

  2. NM_001276285.1 → NP_001263214.1  beta-enolase

    See identical proteins and their annotated locations for NP_001263214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AI841640, AK002485, BY115250, BY784892
    Consensus CDS
    CCDS24961.1
    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase

  3. NM_007933.3 → NP_031959.1  beta-enolase

    See identical proteins and their annotated locations for NP_031959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AI841640, AK002485, BY151264, BY784892
    Consensus CDS
    CCDS24961.1
    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Related
    ENSMUSP00000104188.2, ENSMUST00000108548.8
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70543973..70553339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532161.5 → XP_006532224.1  beta-enolase isoform X1

    See identical proteins and their annotated locations for XP_006532224.1

    UniProtKB/TrEMBL
    Q4FK59
    Conserved Domains (1) summary
    PLN00191
    Location:63 → 517
    PLN00191; enolase

  2. XM_006532162.4 → XP_006532225.1  beta-enolase isoform X2

    See identical proteins and their annotated locations for XP_006532225.1

    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase

  3. XM_030245527.2 → XP_030101387.1  beta-enolase isoform X2

    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase

  4. XM_036156290.1 → XP_036012183.1  beta-enolase isoform X2

    UniProtKB/Swiss-Prot
    P21550
    UniProtKB/TrEMBL
    Q4FK59
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21550.3 GenPept UniProtKB/Swiss-Prot:P21550

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