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Eno1 enolase 1, alpha non-neuron [ Mus musculus (house mouse) ]

Gene ID: 13806, updated on 16-Apr-2024

Summary

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Official Symbol
Eno1provided by MGI
Official Full Name
enolase 1, alpha non-neuronprovided by MGI
Primary source
MGI:MGI:95393
See related
Ensembl:ENSMUSG00000063524 AllianceGenome:MGI:95393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NNE; Eno-1; MBP-1
Summary
Enables RNA binding activity and phosphopyruvate hydratase activity. Acts upstream of or within cellular response to interleukin-7; in utero embryonic development; and positive regulation of binding activity. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 310.6), subcutaneous fat pad adult (RPKM 285.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eno1 in Genome Data Viewer
Location:
4 E2; 4 81.24 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150321165..150333336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150236708..150248879)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52492 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 7 Neighboring gene STARR-seq mESC enhancer starr_12144 Neighboring gene carbonic anhydrase 6 Neighboring gene STARR-positive B cell enhancer ABC_E8035 Neighboring gene STARR-seq mESC enhancer starr_12148 Neighboring gene STARR-seq mESC enhancer starr_12150 Neighboring gene STARR-seq mESC enhancer starr_12151 Neighboring gene predicted gene, 33415 Neighboring gene arginine glutamic acid dipeptide (RE) repeats Neighboring gene small nuclear ribonucleoprotein F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ENO1 promotes immunosuppression and tumor growth in pancreatic cancer. Huang CK, et al. Clin Transl Oncol, 2023 Jul. PMID 36820953
  2. ENOblock inhibits the pathology of diet-induced obesity. Cho H, et al. Sci Rep, 2019 Jan 24. PMID 30679508, Free PMC Article
  3. The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection. Ryans K, et al. BMC Immunol, 2017 May 19. PMID 28525970, Free PMC Article
  4. Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice. Li H, et al. Reprod Toxicol, 2016 Oct. PMID 27460355
  5. Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model. Guillou C, et al. PLoS One, 2015. PMID 26302382, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow.
    Title: Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow.
  2. Unrevealed roles of extracellular enolase-1 (ENO1) in promoting glycolysis and pro-cancer activities in multiple myeloma via hypoxia-inducible factor 1alpha.
    Title: Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α.
  3. ENO1 promotes immunosuppression and tumor growth in pancreatic cancer.
    Title: ENO1 promotes immunosuppression and tumor growth in pancreatic cancer.
  4. TNF-alpha/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells.
    Title: TNF-α/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells.
  5. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer.
    Title: F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer.
  6. our data revealed that ENO1 plays a novel and protective role in cerebral ischemia-induced neuronal injury
    Title: Enolase1 Alleviates Cerebral Ischemia-Induced Neuronal Injury via Its Enzymatic Product Phosphoenolpyruvate.
  7. regulates the metabolic reprogramming and malignant phenotype of pulmonary artery smooth muscle cells in pulmonary arterial hypertension
    Title: Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway.
  8. this paper shows the immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection
    Title: The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection.
  9. Eno1 may be a potential marker for low sperm motility induced by iron ion radiation, and these results may provide a useful reference for changes in astronaut fertility during long space missions.
    Title: Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice.
  10. The results confirmed the altered expression of HFABP, a key fatty acid transport protein, and of enolase and PGK1, the key enzymes in the glycolytic process
    Title: Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103111, MGC107267

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to acid chemical IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-enolase
Names
2-phospho-D-glycerate hydro-lyase
2-phospho-D-glycerate hydrolase
c-Myc promoter binding protein
non-neural enolase
NP_001366056.1
NP_001366057.1
NP_075608.2
XP_036019540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379127.2 → NP_001366056.1  alpha-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606903
    UniProtKB/TrEMBL
    Q6PHC1
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

  2. NM_001379128.1 → NP_001366057.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903
    UniProtKB/Swiss-Prot
    P17182, Q99KT7, Q9DCY7
    UniProtKB/TrEMBL
    Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

  3. NM_001429235.1 → NP_001416164.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903

  4. NM_001429236.1 → NP_001416165.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903

  5. NM_001429237.1 → NP_001416166.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903

  6. NM_001429238.1 → NP_001416167.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903

  7. NM_001429250.1 → NP_001416179.1  alpha-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606903

  8. NM_023119.3 → NP_075608.2  alpha-enolase isoform 2

    See identical proteins and their annotated locations for NP_075608.2

    Status: VALIDATED

    Source sequence(s)
    AL606903
    Consensus CDS
    CCDS18971.1
    UniProtKB/Swiss-Prot
    P17182, Q99KT7, Q9DCY7
    UniProtKB/TrEMBL
    Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    Related
    ENSMUSP00000079727.7, ENSMUST00000080926.13
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    150321165..150333336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163647.1 → XP_036019540.1  alpha-enolase isoform X1

    UniProtKB/TrEMBL
    Q6PHC1
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17182.3 GenPept UniProtKB/Swiss-Prot:P17182

Gene LinkOut

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