Enc1 ectodermal-neural cortex 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Enc1provided by MGI
Official Full Name: ectodermal-neural cortex 1provided by MGI
Primary source: MGI:MGI:109610
See related: Ensembl:ENSMUSG00000041773 AllianceGenome:MGI:109610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrpb; PIG10
Summary: Predicted to enable actin binding activity. Predicted to be involved in cellular protein metabolic process; negative regulation of translation; and positive regulation of neuron projection development. Predicted to be located in chromatin; neuronal cell body; and nuclear lumen. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 112.0), whole brain E14.5 (RPKM 85.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 50.66 cM; 13 D1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (97377613..97389548)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (97241105..97253040)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results are the first to demonstrate a role for ENC1 in the control of osteoblast differentiation. Additionally, the contrasting mineralization phenotypes and transcriptional patterns seen with coordinate knockdown of both ENC1 isoforms vs selective knockdown of 67 kDa ENC1 suggest opposing roles for the isoforms in regulation of osteoblastic differentiation, through effects on Alpl expression and phosphate cellular
Title: Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression.
Pallial expression of Enc1 RNA in postnatal mouse telencephalon.
Title: Pallial expression of Enc1 RNA in postnatal mouse telencephalon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Enc1 (e-PCR), detects polymorphism
- UniSTS:506878

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in proteasomal ubiquitin-independent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasomal ubiquitin-independent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ectoderm-neural cortex protein 1

Names: ENC-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007930.4 → NP_031956.3 ectoderm-neural cortex protein 1

See identical proteins and their annotated locations for NP_031956.3

Status: VALIDATED

Source sequence(s)

AK132173, AV465735

Consensus CDS

CCDS26710.1

UniProtKB/Swiss-Prot

O35709, Q8C7V2

UniProtKB/TrEMBL

Q8BRG4

Related

ENSMUSP00000038783.8, ENSMUST00000041623.9

Conserved Domains (4) summary

PHA03098
Location:48 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18267
Location:6 → 152

BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)

cd18515
Location:145 → 242

BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

97377613..97389548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247139.1 → XP_030102999.1 ectoderm-neural cortex protein 1 isoform X1

UniProtKB/Swiss-Prot

O35709, Q8C7V2

UniProtKB/TrEMBL

Q8BRG4

Conserved Domains (4) summary

PHA03098
Location:48 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18267
Location:6 → 152

BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)

cd18515
Location:145 → 242

BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
XM_030247137.1 → XP_030102997.1 ectoderm-neural cortex protein 1 isoform X1

UniProtKB/Swiss-Prot

O35709, Q8C7V2

UniProtKB/TrEMBL

Q8BRG4

Conserved Domains (4) summary

PHA03098
Location:48 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18267
Location:6 → 152

BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)

cd18515
Location:145 → 242

BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
XM_030247138.1 → XP_030102998.1 ectoderm-neural cortex protein 1 isoform X1

UniProtKB/Swiss-Prot

O35709, Q8C7V2

UniProtKB/TrEMBL

Q8BRG4

Conserved Domains (4) summary

PHA03098
Location:48 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

cd18267
Location:6 → 152

BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)

cd18515
Location:145 → 242

BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)