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Adgre1 adhesion G protein-coupled receptor E1 [ Mus musculus (house mouse) ]

Gene ID: 13733, updated on 11-Apr-2024

Summary

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Official Symbol
Adgre1provided by MGI
Official Full Name
adhesion G protein-coupled receptor E1provided by MGI
Primary source
MGI:MGI:106912
See related
Ensembl:ENSMUSG00000004730 AllianceGenome:MGI:106912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and adaptive immune response. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system; and intestine. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 13.7), mammary gland adult (RPKM 11.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.8 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57665650..57790527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57358581..57483529)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11648 Neighboring gene STARR-positive B cell enhancer ABC_E7549 Neighboring gene STARR-positive B cell enhancer ABC_E9961 Neighboring gene STARR-positive B cell enhancer ABC_E7550 Neighboring gene STARR-positive B cell enhancer ABC_E9962 Neighboring gene STARR-positive B cell enhancer ABC_E8690 Neighboring gene predicted gene, 52326 Neighboring gene vav 1 oncogene Neighboring gene STARR-positive B cell enhancer ABC_E9963 Neighboring gene heat shock protein 8 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene STARR-seq mESC enhancer starr_42922 Neighboring gene vomeronasal 2, receptor 120 Neighboring gene STARR-seq mESC enhancer starr_42923 Neighboring gene STARR-seq mESC enhancer starr_42924 Neighboring gene STARR-seq mESC enhancer starr_42925 Neighboring gene predicted gene, 54014

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders. Legrand F, et al. J Allergy Clin Immunol, 2014 May. PMID 24530099, Free PMC Article
  2. Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term. Ma H, et al. J Mol Med (Berl), 2008 Apr. PMID 18231763
  3. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. Lin HH, et al. J Exp Med, 2005 May 16. PMID 15883173, Free PMC Article
  4. Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages. O'Reilly D, et al. Genomics, 2004 Dec. PMID 15533720
  5. Inactivation of the F4/80 glycoprotein in the mouse germ line. Schaller E, et al. Mol Cell Biol, 2002 Nov. PMID 12391169, Free PMC Article

See all (263) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EMR1 expression is restricted to mature blood and tissue eosinophils. Targeting of eosinophils with afucosylated anti-EMR1 antibody shows promise as a treatment for eosinophilic disorders.
    Title: The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders.
  2. F4/80-expressing necrotic tumor cell-derived monocytes induce apoptosis of activated T cells but not nonstimulated T cells.
    Title: Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.
  3. CD11b and F4/80 appear to participate in conjunctival eosinophil infiltration in allergic conjunctivitis.
    Title: Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis.
  4. Flow analysis indicated little overlap between the F4/80 and CSF-1R-positive populations in peritoneal macrophage.
    Title: Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations.
  5. c-Maf is required for the F4/80 expression in macrophages in vivo.
    Title: c-Maf is essential for the F4/80 expression in macrophages in vivo.
  6. Data show that total cell number and immune function of F4/80+ macrophages are decreased in diabetic mice, and this may play a role in increased macrophage-related complications in diabetic patients.
    Title: Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term.
  7. Expression of CCR2 and F4/80 increased after ethanol feeding in WT mice, but such increase was less evident in H-STAT3KO mice.
    Title: Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
  8. These results demonstrate that MafB is essential for podocyte differentiation, renal tubule survival, and F4/80 maturation in a distinct subpopulation of nonadherent mature macrophages.
    Title: MafB is essential for renal development and F4/80 expression in macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (4) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor E1
Names
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
cell surface glycoprotein F4/80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355722.2 → NP_001342651.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010434
    Consensus CDS
    CCDS50160.1
    UniProtKB/Swiss-Prot
    Q61549
    UniProtKB/TrEMBL
    Q3U1M9, Q3U9R0
    Related
    ENSMUSP00000004850.8, ENSMUST00000004850.8
    Conserved Domains (4) summary
    smart00303
    Location:591 → 640
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222 → 258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:644 → 906
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  2. NM_001355723.2 → NP_001342652.1  adhesion G protein-coupled receptor E1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010434
    UniProtKB/TrEMBL
    Q3U1M9
    Conserved Domains (5) summary
    smart00303
    Location:575 → 624
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:117 → 156
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:206 → 242
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam16489
    Location:420 → 549
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15439
    Location:628 → 890
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  3. NM_001424712.1 → NP_001411641.1  adhesion G protein-coupled receptor E1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010434

  4. NM_010130.5 → NP_034260.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034260.1

    Status: VALIDATED

    Source sequence(s)
    CT010434
    Consensus CDS
    CCDS50160.1
    UniProtKB/Swiss-Prot
    Q61549
    UniProtKB/TrEMBL
    Q3U1M9, Q3U9R0
    Related
    ENSMUSP00000083971.6, ENSMUST00000086763.13
    Conserved Domains (4) summary
    smart00303
    Location:591 → 640
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222 → 258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:644 → 906
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57665650..57790527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160297.1 → XP_036016190.1  adhesion G protein-coupled receptor E1 isoform X1

    UniProtKB/TrEMBL
    Q3U1M9
    Conserved Domains (4) summary
    smart00303
    Location:552 → 601
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222 → 258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:605 → 867
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61549.1 GenPept UniProtKB/Swiss-Prot:Q61549

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