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Emp3 epithelial membrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 13732, updated on 5-Mar-2024

Summary

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Official Symbol
Emp3provided by MGI
Official Full Name
epithelial membrane protein 3provided by MGI
Primary source
MGI:MGI:1098729
See related
Ensembl:ENSMUSG00000040212 AllianceGenome:MGI:1098729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4; H-4; Ymp; MI-35; HNMP-1
Summary
Predicted to be involved in bleb assembly and cell death. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including hemolymphoid system; meninges; skeleton; spinal component of peripheral nervous system; and spinal cord. Orthologous to human EMP3 (epithelial membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 256.9), ovary adult (RPKM 106.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Emp3 in Genome Data Viewer
Location:
7 B3; 7 29.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45567447..45570850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45918023..45921426, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptogyrin 4 Neighboring gene STARR-positive B cell enhancer ABC_E1087 Neighboring gene transmembrane protein 143 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene, 45983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Kusumoto Y, et al. Cell Immunol, 2018 Feb. PMID 29269102
  2. Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Aherrahrou Z, et al. Physiol Genomics, 2007 Jan 17. PMID 16926270
  3. A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen. Luedtke B, et al. Immunogenetics, 2003 Aug. PMID 12845499
  4. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. Bolin LM, et al. J Neurosci, 1997 Jul 15. PMID 9204931, Free PMC Article
  5. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. Ben-Porath I, et al. Gene, 1996 Dec 12. PMID 8996089

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Not Applicable (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epithelial membrane protein 3
Names
EMP-3
hematopoietic neural membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146346.1 → NP_001139818.1  epithelial membrane protein 3

    See identical proteins and their annotated locations for NP_001139818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK146939, AV024057, U87948
    Consensus CDS
    CCDS21270.1
    UniProtKB/Swiss-Prot
    O35912, O88333, Q3UIF8
    Related
    ENSMUSP00000132519.2, ENSMUST00000164119.3
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_010129.2 → NP_034259.2  epithelial membrane protein 3

    See identical proteins and their annotated locations for NP_034259.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AV024057, CK022835, U87948
    Consensus CDS
    CCDS21270.1
    UniProtKB/Swiss-Prot
    O35912, O88333, Q3UIF8
    Related
    ENSMUSP00000037289.6, ENSMUST00000038876.13
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45567447..45570850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35912.2 GenPept UniProtKB/Swiss-Prot:O35912

Gene LinkOut

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