Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aimp1provided by MGI
Official Full Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by MGI
Primary source: MGI:MGI:102774
See related: Ensembl:ENSMUSG00000028029 AllianceGenome:MGI:102774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p43; Emap2; Scye1; EMAPII; AIMP1/p43; 9830137A06Rik
Summary: Enables cytokine activity. Involved in leukocyte migration and positive regulation of glucagon secretion. Located in extracellular space. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 32.1), placenta adult (RPKM 29.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 61.48 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (132366259..132390151, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (132660498..132684390, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.
Title: Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.
Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Title: Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
The Role of the AIMP1 Pathway in Diabetic Retinopathy: AIMP1-Targeted Intervention Study in Diabetic Retinopathy.
Title: The Role of the AIMP1 Pathway in Diabetic Retinopathy: AIMP1-Targeted Intervention Study in Diabetic Retinopathy.
Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development.
Title: Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development.
AIMP1 regulates TCR signaling and induces differentiation of regulatory T cells by interfering with lipid raft association.
Title: AIMP1 regulates TCR signaling and induces differentiation of regulatory T cells by interfering with lipid raft association.
results show that AIMP1 induces antitumor responses by NK cell activation mainly via macrophages
Title: Aminoacyl tRNA Synthetase--Interacting Multifunctional Protein 1 Activates NK Cells via Macrophages In Vitro and In Vivo.
Blockade of EMAP II induces angiogenesis and improves cardiac function following chronic myocardial infarction.
Title: Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis.
findings indicate that Aimp1 might act as an important regulator to remodel the uterine endometrium and its expression might be regulated by estrogen during the estrous cycle.
Title: The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus.
our results show that AIMP1 acts as a novel B cell-activating factor
Title: Aminoacyl tRNA Synthetase-Interacting Multifunctional Protein 1 Acts as a Novel B Cell-Activating Factor In Vitro and In Vivo.
The data showed that AIMP1 is a negative regulator of TH2 immune responses, mainly via CD4+ T cells.
Title: AIMP1 deficiency enhances airway hyperreactivity in mice via increased TH2 immune responses.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Scye1 (e-PCR), detects polymorphism
- UniSTS:471179

RH136362 (e-PCR)
- UniSTS:210352

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucagon secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Names: ARS inducible multifunctional protein 1; endothelial monocyte activating polypeptide 2; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368626.1 → NP_001355555.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC135118

Consensus CDS

CCDS89689.1

UniProtKB/Swiss-Prot

P31230, Q60659

UniProtKB/TrEMBL

Q8C2U7

Related

ENSMUSP00000142513.3, ENSMUST00000198513.6
NM_007926.2 → NP_031952.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 1

See identical proteins and their annotated locations for NP_031952.2

Status: VALIDATED

Source sequence(s)

AK133859, BY256548, BY631162

Consensus CDS

CCDS38642.1

UniProtKB/TrEMBL

Q3UZG4, Q8C2U7

Related

ENSMUSP00000029663.7, ENSMUST00000029663.11

Conserved Domains (2) summary

cd02799
Location:157 → 259

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

pfam04880
Location:17 → 117

NUDE_C; NUDE protein, C-terminal conserved region