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Elf5 E74-like factor 5 [ Mus musculus (house mouse) ]

Gene ID: 13711, updated on 11-Apr-2024

Summary

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Official Symbol
Elf5provided by MGI
Official Full Name
E74-like factor 5provided by MGI
Primary source
MGI:MGI:1335079
See related
Ensembl:ENSMUSG00000027186 AllianceGenome:MGI:1335079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESE-2; ESE-5; ESE-5.
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ectodermal cell fate commitment; mammary gland epithelial cell differentiation; and somatic stem cell population maintenance. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; integumental system; and respiratory system epithelium. Orthologous to human ELF5 (E74 like ETS transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 8.8), mammary gland adult (RPKM 6.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Elf5 in Genome Data Viewer
Location:
2 E2; 2 54.43 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103242443..103281334)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103412098..103450989)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene STARR-seq mESC enhancer starr_05269 Neighboring gene cDNA sequence BC016548 Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcription factor ELF5 is essential for early preimplantation development. Alotaibi H. Mol Biol Rep, 2023 Mar. PMID 36542237
  2. ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. Li K, et al. Sci Rep, 2017 Mar 13. PMID 28287091, Free PMC Article
  3. Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Chakrabarti R, et al. Stem Cells, 2012 Jul. PMID 22523003, Free PMC Article
  4. Lineage specific methylation of the Elf5 promoter in mammary epithelial cells. Lee HJ, et al. Stem Cells, 2011 Oct. PMID 21823211
  5. Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5. Rogers RL, et al. PLoS One, 2010 Oct 7. PMID 20949099, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
    Title: ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
  2. The transcription factor ELF5 is essential for early preimplantation development.
    Title: The transcription factor ELF5 is essential for early preimplantation development.
  3. MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
    Title: MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
  4. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
    Title: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
  5. Downregulation of ELF5 increases the expression of AR-response genes and the progression of prostate cancer. ELF5 interaction with AR is androgen dependent.
    Title: ELF5-Mediated AR Activation Regulates Prostate Cancer Progression.
  6. Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 and Avpr2 genes.
    Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
  7. Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 pathway.
    Title: Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation.
  8. Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC proliferation and differentiation
    Title: Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.
  9. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
    Title: Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner.
  10. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
    Title: Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ectoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ectodermal cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mammary gland epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ETS-related transcription factor Elf-5
Names
Epithelium specific Ets-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145813.1 → NP_001139285.1  ETS-related transcription factor Elf-5

    See identical proteins and their annotated locations for NP_001139285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK132484, AL773505
    Consensus CDS
    CCDS16477.1
    UniProtKB/Swiss-Prot
    Q8VDK3, Q921H5, Q9Z2K6
    UniProtKB/TrEMBL
    Q3ULZ4, Q3V1F7
    Related
    ENSMUSP00000126941.2, ENSMUST00000164172.8
    Conserved Domains (2) summary
    cd08538
    Location:39 → 122
    SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
    smart00413
    Location:162 → 246
    ETS; erythroblast transformation specific domain

  2. NM_010125.3 → NP_034255.2  ETS-related transcription factor Elf-5

    See identical proteins and their annotated locations for NP_034255.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AF049702, AK132484, AK145214, AL773505
    Consensus CDS
    CCDS16477.1
    UniProtKB/Swiss-Prot
    Q8VDK3, Q921H5, Q9Z2K6
    UniProtKB/TrEMBL
    Q3ULZ4, Q3V1F7
    Related
    ENSMUSP00000028609.8, ENSMUST00000028609.14
    Conserved Domains (2) summary
    cd08538
    Location:39 → 122
    SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
    smart00413
    Location:162 → 246
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103242443..103281334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498705.3 → XP_006498768.1  ETS-related transcription factor Elf-5 isoform X1

    See identical proteins and their annotated locations for XP_006498768.1

    UniProtKB/Swiss-Prot
    Q8VDK3, Q921H5, Q9Z2K6
    UniProtKB/TrEMBL
    Q3ULZ4, Q3V1F7
    Conserved Domains (2) summary
    cd08538
    Location:39 → 122
    SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
    smart00413
    Location:162 → 246
    ETS; erythroblast transformation specific domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDK3.2 GenPept UniProtKB/Swiss-Prot:Q8VDK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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