Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4ebp2provided by MGI
Official Full Name: eukaryotic translation initiation factor 4E binding protein 2provided by MGI
Primary source: MGI:MGI:109198
See related: Ensembl:ENSMUSG00000020091 AllianceGenome:MGI:109198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4E-BP2; PHAS-II; 2810011I19Rik
Summary: Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and insulin receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 49.7), liver adult (RPKM 46.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.21 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (61268276..61288448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (61428491..61452790, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes.
Title: 4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes.
Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle.
Title: Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle.
4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Title: 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Diabetes enhances translation of Cd40 mRNA in murine retinal Muller glia via a 4E-BP1/2-dependent mechanism.
Title: Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2-dependent mechanism.
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-kappaB Activity.
Title: Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
4E-BP1 and 4E-BP2 contributes to the maintenance of muscle mass and function in aging through increased protein synthesis. Through metabolomic and global lipid analysis, study demonstrated that 4E-BPs play a role in the control of energy and amino acid metabolism in the skeletal muscle of 24-month-old mice. Thus, 4E-BPs may be potential drug targets in the treatment of sarcopenia.
Title: 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.
evidence for an inhibitory-cell-specific role of 4E-BP2 in engendering autism-related behaviors.
Title: Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.
Genetic deletion of 4E-BP1/2 in macrophages increased endogenous IL-10.
Title: eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2.
4E-BP proteins may prevent excess lipid accumulation in skeletal muscle and suggest that 4E-BPs are key regulators of muscle homeostasis regardless of insulin sensitivity.
Title: Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.
decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1.
Title: Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236361

NoName (e-PCR)
- UniSTS:487634

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translational initiation	TAS Traceable Author Statement more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E-binding protein 2

Names: eIF4E-binding protein 2; phosphorylated heat- and acid-stable protein regulated by insulin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010124.2 → NP_034254.1 eukaryotic translation initiation factor 4E-binding protein 2

See identical proteins and their annotated locations for NP_034254.1

Status: PROVISIONAL

Source sequence(s)

AC122197

Consensus CDS

CCDS23879.1

UniProtKB/Swiss-Prot

P70445

UniProtKB/TrEMBL

Q3UFP6, Q3UZD4

Related

ENSMUSP00000020288.8, ENSMUST00000020288.15

Conserved Domains (1) summary

pfam05456
Location:13 → 120

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)