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Eif1a eukaryotic translation initiation factor 1A [ Mus musculus (house mouse) ]

Gene ID: 13664, updated on 11-Apr-2024

Summary

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Official Symbol
Eif1aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 1Aprovided by MGI
Primary source
MGI:MGI:95298
See related
Ensembl:ENSMUSG00000057561 AllianceGenome:MGI:95298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ef1a; Eftu; Eif4c; eIF-1A; eIF-4C
Summary
Predicted to enable ribosomal large subunit binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human EIF1AY (eukaryotic translation initiation factor 1A Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 35.4), bladder adult (RPKM 15.3) and 28 other tissues See more
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Genomic context

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Location:
18 C; 18 24.68 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46730771..46743292)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46597704..46610225)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RAD51 homolog c pseudogene Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene predicted gene 3734 Neighboring gene STARR-seq mESC enhancer starr_44514 Neighboring gene predicted gene, 54021

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Real-time reverse transcription-polymerase chain reaction analysis of translation initiation factor 1A (eIF-1A) in human and mouse preimplantation embryos. Lindeberg M, et al. Reprod Biomed Online, 2004 Mar. PMID 15038901
  2. Molecular cloning and expression of the mouse translation initiation factor eIF-1A. Davis W Jr, et al. Nucleic Acids Res, 1998 Oct 15. PMID 9753744, Free PMC Article
  3. Mapping of the eukaryotic initiation factor eIF-1A gene, Eif1a, to mouse chromosome 12D-E by FISH. Kikyo N, et al. Mamm Genome, 1997 May. PMID 9107689
  4. Transient expression of translation initiation factor eIF-4C during the 2-cell stage of the preimplantation mouse embryo: identification by mRNA differential display and the role of DNA replication in zygotic gene activation. Davis W Jr, et al. Dev Biol, 1996 Mar 15. PMID 8631492
  5. Expression of a gene for mouse eucaryotic elongation factor Tu during murine erythroleukemic cell differentiation. Roth WW, et al. Mol Cell Biol, 1987 Nov. PMID 3481036, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development.
    Title: Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development.
  2. Imp13 is able to bind and export eIF1A in vivo and that its function is essential.
    Title: Structural basis for the nuclear export activity of Importin13.
  3. Inhibiting the first round increased the expression levels of hsp70.1, eif-1a and zscan4d but decreased that of muerv, while inhibiting the second round increased the expression levels of all four genes.
    Title: Roles of the first and second round of DNA replication in the regulation of zygotic gene activation in mice.
  4. mGluR-LTD was associated with increased synthesis of the 5'TOP-encoded protein elongation factor 1A (EF1A).
    Title: mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice.
  5. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
    Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic 43S preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 48S preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
part_of multi-eIF complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 1A
Names
eukaryotic translation initiation factor 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374654.1 → NP_001361583.1  eukaryotic translation initiation factor 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127342
    UniProtKB/TrEMBL
    A0A494BB95
    Related
    ENSMUSP00000158417.2, ENSMUST00000237478.2
    Conserved Domains (1) summary
    PTZ00329
    Location:111 → 241
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

  2. NM_010120.5 → NP_034250.3  eukaryotic translation initiation factor 1A isoform 2

    See identical proteins and their annotated locations for NP_034250.3

    Status: VALIDATED

    Source sequence(s)
    AK013268, AK019451, AK150673, CN722607
    Consensus CDS
    CCDS29233.1
    UniProtKB/Swiss-Prot
    O88847, Q60872, Q8R2M4, Q9CX76, Q9DB61
    UniProtKB/TrEMBL
    Q3UC76, Q4FJR7
    Related
    ENSMUSP00000077223.4, ENSMUST00000078079.11
    Conserved Domains (1) summary
    PTZ00329
    Location:1 → 131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    46730771..46743292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60872.3 GenPept UniProtKB/Swiss-Prot:Q60872

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