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Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

Gene ID: 13649, updated on 10-Dec-2024

Summary

Official Symbol
Egfrprovided by MGI
Official Full Name
epidermal growth factor receptorprovided by MGI
Primary source
MGI:MGI:95294
See related
Ensembl:ENSMUSG00000020122 AllianceGenome:MGI:95294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik
Summary
Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in several processes, including ERBB2-EGFR signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; hair follicle development; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver adult (RPKM 26.7), liver E18 (RPKM 8.7) and 15 other tissues See more
Orthologs
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Genomic context

See Egfr in Genome Data Viewer
Location:
11 A2; 11 9.41 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16700153..16868158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16752203..16913907)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12664 Neighboring gene predicted gene, 39583 Neighboring gene STARR-positive B cell enhancer mm9_chr11:16641095-16641396 Neighboring gene predicted gene, 25698 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene pleckstrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 58
Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables actin filament binding  
enables actin filament binding  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables calmodulin binding  
enables calmodulin binding  
enables chromatin binding  
enables chromatin binding  
enables enzyme binding  
enables epidermal growth factor binding  
enables epidermal growth factor binding PubMed 
enables epidermal growth factor binding  
enables epidermal growth factor receptor activity PubMed 
enables epidermal growth factor receptor activity PubMed 
enables epidermal growth factor receptor activity PubMed 
contributes_to epidermal growth factor receptor activity  
enables epidermal growth factor receptor activity PubMed 
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables identical protein binding  
enables identical protein binding  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables integrin binding  
enables integrin binding  
enables kinase activity PubMed 
enables kinase binding  
enables macrophage colony-stimulating factor receptor activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein kinase binding  
enables protein kinase binding  
enables protein phosphatase binding  
enables protein phosphatase binding  
enables protein tyrosine kinase activator activity  
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity  
enables protein tyrosine kinase collagen receptor activity  
enables protein-containing complex binding  
enables signaling receptor binding  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity PubMed 
enables transmembrane receptor protein tyrosine kinase activity PubMed 
enables transmembrane receptor protein tyrosine kinase activity PubMed 
enables transmembrane signaling receptor activity  
enables transmembrane-ephrin receptor activity  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
enables vascular endothelial growth factor receptor activity  
Items 1 - 25 of 58
Items 1 - 25 of 164
Process Evidence Code Pubs
involved_in ERBB2-EGFR signaling pathway PubMed 
involved_in ERBB2-EGFR signaling pathway PubMed 
involved_in ERBB2-EGFR signaling pathway PubMed 
involved_in Kit signaling pathway  
involved_in astrocyte activation  
involved_in astrocyte activation  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
acts_upstream_of_or_within cell morphogenesis PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
acts_upstream_of_or_within cell surface receptor signaling pathway  
involved_in cell-cell adhesion  
involved_in cell-cell adhesion  
involved_in cellular response to amino acid stimulus PubMed 
involved_in cellular response to cadmium ion  
involved_in cellular response to dexamethasone stimulus  
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to estradiol stimulus  
involved_in cellular response to estradiol stimulus  
acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
involved_in cellular response to mechanical stimulus  
involved_in cellular response to reactive oxygen species  
involved_in cellular response to xenobiotic stimulus  
acts_upstream_of_or_within cerebral cortex cell migration PubMed 
involved_in chromatin remodeling  
involved_in circadian rhythm  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
acts_upstream_of_or_within digestive tract morphogenesis PubMed 
involved_in diterpenoid metabolic process  
acts_upstream_of_or_within embryonic placenta development PubMed 
involved_in ephrin receptor signaling pathway  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within epidermis development PubMed 
acts_upstream_of epithelial cell proliferation PubMed 
acts_upstream_of_or_within eyelid development in camera-type eye PubMed 
involved_in fibroblast growth factor receptor signaling pathway  
acts_upstream_of_or_within hair follicle development PubMed 
acts_upstream_of_or_within hair follicle development PubMed 
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in hydrogen peroxide metabolic process  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in learning or memory  
involved_in learning or memory  
involved_in liver regeneration  
involved_in liver regeneration  
involved_in lung development  
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in midgut development  
acts_upstream_of_or_within morphogenesis of an epithelial fold PubMed 
involved_in multicellular organism development  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cardiocyte differentiation  
involved_in negative regulation of cardiocyte differentiation  
involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
involved_in negative regulation of mitotic cell cycle  
involved_in negative regulation of mitotic cell cycle  
involved_in negative regulation of protein catabolic process  
involved_in negative regulation of protein catabolic process  
involved_in neurogenesis  
involved_in neuron projection morphogenesis  
involved_in neuron projection morphogenesis  
involved_in ovulation cycle  
involved_in ovulation cycle  
involved_in peptidyl-tyrosine autophosphorylation  
involved_in peptidyl-tyrosine phosphorylation  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of DNA repair  
involved_in positive regulation of DNA repair  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of G1/S transition of mitotic cell cycle  
involved_in positive regulation of G1/S transition of mitotic cell cycle  
involved_in positive regulation of MAP kinase activity  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of bone resorption  
involved_in positive regulation of bone resorption  
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
involved_in positive regulation of epithelial cell proliferation  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of fibroblast proliferation PubMed 
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of mucus secretion  
involved_in positive regulation of mucus secretion  
involved_in positive regulation of non-canonical NF-kappaB signal transduction  
involved_in positive regulation of peptidyl-serine phosphorylation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphorylation  
involved_in positive regulation of prolactin secretion  
involved_in positive regulation of prolactin secretion  
involved_in positive regulation of protein kinase C activity  
involved_in positive regulation of protein localization to early endosome  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein phosphorylation  
involved_in positive regulation of protein phosphorylation  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of superoxide anion generation  
involved_in positive regulation of superoxide anion generation  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of vasoconstriction  
involved_in positive regulation of vasoconstriction  
acts_upstream_of_or_within protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of JNK cascade  
acts_upstream_of_or_within regulation of cell population proliferation PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in response to UV-A  
involved_in response to UV-A  
involved_in response to calcium ion  
involved_in response to calcium ion  
involved_in response to cobalamin  
involved_in response to hydroxyisoflavone  
involved_in response to oxidative stress  
acts_upstream_of_or_within salivary gland morphogenesis PubMed 
acts_upstream_of_or_within signal transduction PubMed 
involved_in signal transduction  
involved_in tongue development  
involved_in translation  
involved_in translation  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
involved_in vasodilation  
involved_in vasodilation  
Items 1 - 25 of 164
Items 1 - 20 of 44
Component Evidence Code Pubs
located_in Golgi membrane  
located_in apical plasma membrane  
located_in apical plasma membrane  
is_active_in basal plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in cell junction  
located_in cell surface PubMed 
located_in cell surface  
located_in cytoplasm  
located_in early endosome membrane  
located_in early endosome membrane  
located_in endocytic vesicle PubMed 
located_in endocytic vesicle  
located_in endoplasmic reticulum membrane  
colocalizes_with endosome  
located_in endosome  
located_in endosome  
located_in endosome membrane  
located_in glutamatergic synapse  
located_in intracellular anatomical structure PubMed 
located_in intracellular vesicle  
located_in membrane  
located_in membrane raft  
located_in membrane raft  
located_in multivesicular body, internal vesicle lumen  
located_in multivesicular body, internal vesicle lumen  
located_in nuclear membrane  
located_in nucleus PubMed 
located_in nucleus  
located_in perinuclear region of cytoplasm PubMed 
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
is_active_in plasma membrane PubMed 
located_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
located_in plasma membrane  
part_of protein-containing complex  
part_of receptor complex  
part_of receptor complex PubMed 
located_in ruffle membrane  
is_active_in ruffle membrane  
located_in synaptic membrane  
Items 1 - 20 of 44

General protein information

Preferred Names
epidermal growth factor receptor
Names
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
waved 2
NP_031938.1
NP_997538.1
XP_036012181.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007912.4NP_031938.1  epidermal growth factor receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_031938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK004883, AK004944
    Consensus CDS
    CCDS24444.1
    UniProtKB/TrEMBL
    Q5SVE9, Q9ERV6, Q9WVF5
    Related
    ENSMUSP00000099948.4, ENSMUST00000102884.10
    Conserved Domains (5) summary
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:184335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV
  2. NM_207655.2NP_997538.1  epidermal growth factor receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_997538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF275367, AK004883, AK163338, BQ553815, BY725722
    Consensus CDS
    CCDS24443.1
    UniProtKB/Swiss-Prot
    Q01279
    UniProtKB/TrEMBL
    Q9EP98
    Related
    ENSMUSP00000020329.7, ENSMUST00000020329.13
    Conserved Domains (8) summary
    smart00219
    Location:715970
    TyrKc; Tyrosine kinase, catalytic domain
    cd12093
    Location:634679
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:7061018
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:184335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16700153..16868158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156288.1XP_036012181.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    Q9EP98
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