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Efs embryonal Fyn-associated substrate [ Mus musculus (house mouse) ]

Gene ID: 13644, updated on 11-Apr-2024

Summary

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Official Symbol
Efsprovided by MGI
Official Full Name
embryonal Fyn-associated substrateprovided by MGI
Primary source
MGI:MGI:105311
See related
Ensembl:ENSMUSG00000022203 AllianceGenome:MGI:105311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables SH3 domain binding activity. Predicted to be involved in actin filament reorganization; cell migration; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 32.5), ovary adult (RPKM 23.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 27.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55154087..55164222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54916543..54926788, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Donlin LT, et al. Mol Cell Biol, 2005 Dec. PMID 16314525, Free PMC Article
  2. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. Ishino M, et al. Oncogene, 1997 Oct 2. PMID 9349509
  3. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Ishino M, et al. Oncogene, 1995 Dec 7. PMID 8570184
  4. Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. Danzl NM, et al. J Exp Med, 2010 May 10. PMID 20404100, Free PMC Article
  5. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. Polte TR, et al. J Biol Chem, 1997 Feb 28. PMID 9038154

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
    Title: Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
embryonal Fyn-associated substrate
Names
SRC-interacting protein
signal-integrating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424432.1 → NP_001411361.1  embryonal Fyn-associated substrate isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025533
    UniProtKB/TrEMBL
    A0A2I3BRP5

  2. NM_001424433.1 → NP_001411362.1  embryonal Fyn-associated substrate isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025533

  3. NM_001424434.1 → NP_001411363.1  embryonal Fyn-associated substrate isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025533

  4. NM_010112.5 → NP_034242.2  embryonal Fyn-associated substrate isoform 1

    See identical proteins and their annotated locations for NP_034242.2

    Status: VALIDATED

    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS36925.1
    UniProtKB/Swiss-Prot
    Q64355, Q8BSX4
    UniProtKB/TrEMBL
    Q8K0F6
    Related
    ENSMUSP00000022813.7, ENSMUST00000022813.8
    Conserved Domains (2) summary
    cd12003
    Location:8 → 70
    SH3_EFS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Embryonal Fyn-associated Substrate
    cl13463
    Location:371 → 555
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55154087..55164222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64355.2 GenPept UniProtKB/Swiss-Prot:Q64355

Gene LinkOut

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